38 research outputs found
Verification of the Microgravity Active Vibration Isolation System based on Parabolic Flight
No full textCan We Model Nitric Oxide Biotransport? A Survey of Mathematical Models for a Simple Diatomic Molecule with Surprisingly Complex Biological Activities
No full textThe Molecular Mechanism of Opening the Helix Bundle Crossing (HBC) Gate of a Kir Channel
No full textRecurrent Gastric Perforation as a Late Complication of Radiotherapy for Mucosa-Associated Lymphoid Tissue Lymphoma of the Stomach
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Paget's disease of the ectopic breast with an underlying intraductal carcinoma: report of a case
No full textSelective binding of a toxin and phosphatidylinositides to a mammalian potassium channel
No full textChanging perspectives on how the permeation pathway through potassium channels is regulated
No full textThe primary means by which ion permeation through potassium channels is controlled, and the key to selective intervention in a range of pathophysiological conditions, is the process by which channels switch between non-conducting and conducting states. Conventionally, this has been explained by a steric mechanism in which the pore alternates between two conformations: a 'closed' state in which the conduction pathway is occluded and an 'open' state in which the pathway is sufficiently wide to accommodate fully hydrated ions. Recently, however, 'non-canonical' mechanisms have been proposed for some classes of K+ channels. The purpose of this review is to illuminate structural and dynamic relationships underpinning permeation control in K+ channels, indicating where additional data might resolve some of the remaining issues
