Hydroxytyrosol but not resveratrol ingestion induced an acute increment of post exercise blood flow in brachial artery

The aim of this study was to test if previous ingestion of compounds containing resveratrol or hydroxytyrosol, followed by an exhausting hand grip exercise, could induce an acute post-exercise increase in brachial blood flow. Six healthy subjects (three males and three females, 35 ± 7 years), 60 minutes after ingestion of a capsule containing 200 mg of resveratrol or 30 ml of extra virgin olive oil enriched with tyrosol, oleuropein and hydroxytyrosol, performed a hand grip exercise equal to half of their maximum strength until they were no longer able to express the same force (2-day interval between tests). The nonparametric Wilcoxon signed rank test was used for statistical evaluations. Brachial artery blood flow (Fba) and both blood velocity (Vba) and artery diameter (Dba) were assessed immediately after exercise cessation by means of colour Doppler ultrasound. After ingestion of the oil mixture the post-exercise value of Fba median was 2.4 times higher than that after ingestion of the resveratrol compound (P = 0.03), and also the Vba median concerning the hydroxytyrosol was 1.9 times higher than that of the resveratrol (P = 0.03). Both functional foods did not lead to a significant difference in the Dba medians. These results indicate that hydroxytyrosol, but not resveratrol, may be an effective adjuvant of recreational or agonistic, long-lasting sports performances, thanks to the powerful blood flow increment which can be obtained as soon as one hour from its oral intake

Nervous facilitation in cardiodynamic response of exercising athletes to superimposed mental tasks: implications in depressive disorder

Introduction : Motor commands to perform exercise tasks may also induce activation of cardiovascular centres to supply the energy needs of the contracting muscles. Mental stressors per se may also influence cardiovascular homeostasis. We investigated the cardiovascular response of trained runners simultaneously engaged in mental and physical tasks to establish if aerobically trained subjects could develop, differently from untrained ones, nervous facilitation in the brain cardiovascular centre. Methods : Cardiovascular responses of 8 male middle-distance runners (MDR), simultaneously engaged in mental (colour-word interference test) and physical (cycle ergometer exercise) tasks, were compared with those of 8 untrained subjects. Heart rate, cardiac (CI) and stroke indexes were assessed by impedance cardiography while arterial blood pressures were assessed with a brachial sphygmomanometer. Results : Only in MDR simultaneous engagement in mental and physical tasks induced a significant CI increase which was higher (p<0.05) than that obtained on summing CI values from each task separately performed. Conclusion : Aerobic training, when performed together with a mental effort, induced a CI oversupply which allowed a redundant oxygen delivery to satisfy a sudden fuel demand from exercising muscles by utilizing aerobic sources of ATP, thus shifting the anaerobic threshold towards a higher work load. From data of this study it may also be indirectly stated that, in patients with major depressive disorder, the promotion of regular low-intensity exercise together with mental engagement could ameliorate the perceived physical quality of life, thus reducing their heart risk associated with physical stress

Improvement in Hemodynamic Responses to Metaboreflex Activation after One Year of Training in Spinal Cord Injured Humans

Spinal cord injured (SCI) individuals show an altered hemodynamic response to metaboreflex activation due to a reduced capacity to vasoconstrict the venous and arterial vessels below the level of the lesion. Exercise training was found to enhance circulating catecholamines and to improve cardiac preload and venous tone in response to exercise in SCI subjects. Therefore, training would result in enhanced diastolic function and capacity to vasoconstrict circulation. The aim of this study was to test the hypothesis that one year of training improves hemodynamic response to metaboreflex activation in these subjects. Nine SCI individuals were enrolled and underwent a metaboreflex activation test at the beginning of the study (T0) and after one year of training (T1). Hemodynamics were assessed by impedance cardiography and echocardiography at both T0 and T1. Results show that there was an increment in cardiac output response due to metaboreflex activity at T1 as compared to T0 (545.4 ± 683.9 mL · min(-1) versus 220.5 ± 745.4 mL · min(-1), P < 0.05). Moreover, ventricular filling rate response was higher at T1 than at T0. Similarly, end-diastolic volume response was increased after training. We concluded that a period of training can successfully improve hemodynamic response to muscle metaboreflex activation in SCI subjects

EFFECTS OF SIX MONTHS TRAINING ON PHYSICAL CAPACITY AND METABOREFLEX ACTIVITY IN PATIENTS WITH MULTIPLE SCLEROSIS.

Patients with multiple sclerosis (MS) have an increased systemic vascular resistance (SVR) response during the metaboreflex. It has been hypothesized that this is the consequence of a sedentary lifestyle secondary to MS. The purpose of this study was to discover whether a 6-month training program could reverse this hemodynamic dysregulation. Patients were randomly assigned to one of the following two groups: the intervention group (MSIT, n = 11), who followed an adapted training program: and the control group (MSCTL, n = 10), who continued with their sedentary lifestyle. Cardiovascular response during the metaboreflex was evaluated using the post-exercise muscle ischemia (PEMI) method and during a control exercise recovery (CER) test. The difference in hemodynamic variables such as stroke volume (SV), cardiac output (CO), and SVR between the PEMI and the CER tests was calculated to assess the metaboreflex response. Moreover, physical capacity was measured during a cardiopulmonary test till exhaustion. All tests were repeated after 3 and 6 months (T3 and T6, respectively) from the beginning of the study. The main result was that the MSIT group substantially improved parameters related to physical capacity (+5.31 +/- 5.12 ml-min(-1)/kg in maximal oxygen uptake at T6) in comparison with the MSCTL group (-0.97 +/- 4.89 ml.min(-1)/kg at T6; group effect: p = 0.0004). However, none of the hemodynamic variables changed in response to the metaboreflex activation. It was concluded that a 6-month period of adapted physical training was unable to reverse the hemodynamic dys-regulation in response to metaboreflex activation in these patients

Role of heart rate and stroke volume during muscle metaboreflex-induced cardiac output increase: differences between activation during and after exercise

We hypothesized that the role of stroke volume (SV) in the metaboreflex-induced cardiac output (CO) increase was blunted when the metaboreflex was stimulated by exercise muscle ischemia (EMI) compared with post-exercise muscle ischemia (PEMI), because during EMI heart rate (HR) increases and limits diastolic filling. Twelve healthy volunteers were recruited and their hemodynamic responses to the metaboreflex evoked by EMI, PEMI, and by a control dynamic exercise were assessed. The main finding was that the blood pressure increment was very similar in the EMI and PEMI settings. In both conditions the main mechanism used to raise blood pressure was a CO elevation. However, during the EMI test CO was increased as a result of HR elevation whereas during the PEMI test CO was increased as a result of an increase in SV. These results were explainable on the basis of the different HR behavior between the two settings, which in turn led to different diastolic time and myocardial performance

Assessment of the specificity of cardiopulmonary response during tethered swimming using a new snorkel device

This study aimed at comparing maximal oxygen uptake (VO2max), maximal heart rate (HRmax), and anaerobic threshold (AT) obtained from tethered swimming (SW) and three other testing procedures: cycling (CY), running (RU), and arm cranking (AC). Variables were assessed in 12 trained male swimmers by a portable gas analyzer connected to a modified snorkel system to allow expired gases collection during swimming. Athletes exhibited a higher VO2max during the SW test as compared to the CY and the AC tests. There was no significant difference in VO2max between the SW and the RU test, but the Bland and Altman plot highlighted a poor agreement between results. Moreover, AT occurred at higher workloads during SW in comparison to the other tests. These results do not support the use of any unspecific testing procedures to estimate VO2max, HRmax, and AT for swimming

Observations of supernova remnants with the Sardinia Radio Telescope

In the frame of the Astronomical Validation activities for the 64m Sardinia Radio Telescope, we performed 5-22 GHz imaging observations of the complex-morphology supernova remnants (SNRs) W44 and IC443. We adopted innovative observing and mapping techniques providing unprecedented accuracy for single-dish imaging of SNRs at these frequencies, revealing morphological details typically available only at lower frequencies through interferometry observations. High-frequency studies of SNRs in the radio range are useful to better characterize the spatially-resolved spectra and the physical parameters of different regions of the SNRs interacting with the ISM. Furthermore, synchrotron-emitting electrons in the high-frequency radio band are also responsible for the observed high-energy phenomenology as -e.g.- Inverse Compton and bremsstrahlung emission components observed in gamma-rays, to be disentangled from hadron emission contribution (providing constraints on the origin of cosmic rays)

Modelling high-resolution spatially-resolved Supernova Remnant spectra with the Sardinia Radio Telescope

Supernova Remnants (SNRs) exhibit spectra featured by synchrotron radio emission arising from the relativistic electrons, and high-energy emission from both leptonic (Bremsstrahlung and Inverse Compton) and hadronic processes (π0 mesons decay) which are a direct signature of cosmic rays acceleration. Thanks to radio single-dish imaging observations obtained in three frequency bands (1.6, 7, 22 GHz) with the Sardinia Radio Telescope (www.srt.inaf.it), we can model different SNR regions separately. Indeed, in order to disentangle interesting and peculiar hadron contributions in the high-energy spectra (gamma-ray band) and better constrain SNRs as cosmic rays emitters, it is crucial to fully constrain lepton contributions first through radio-observed parameters. In particular, the Bremsstrahlung and Inverse Compton bumps observed in gamma-rays are bounded to synchrotron spectral slope and cut-off in the radio domain. Since these parameters vary for different SNR regions and electron populations, spatially-resolved radio spectra are then required for accurate multi-wavelength modelling

Investigating the high-frequency spectral features of SNRs Tycho, W44, and IC443 with the Sardinia Radio Telescope

The main characteristics in the radio continuum spectra of Supernova Remnants (SNRs) result from simple synchrotron emission. In addition, electron acceleration mechanisms can shape the spectra in specific ways, especially at high radio frequencies. These features are connected to the age and the peculiar conditions of the local interstellar medium interacting with the SNR. Whereas the bulk radio emission is expected at up to 20-50 GHz, sensitive high-resolution images of SNRs above 10 GHz are lacking and are not easily achievable, especially in the confused regions of the Galactic Plane. In the framework of the early science observations with the Sardinia Radio Telescope in February-March 2016, we obtained high-resolution images of SNRs Tycho, W44, and IC443 that provided accurate integrated flux density measurements at 21.4 GHz: 8.8 ± 0.9 Jy for Tycho, 25 ± 3 Jy for W44, and 66 ± 7 Jy for IC443. We coupled the SRT measurements with radio data available in the literature in order to characterize the integrated and spatially resolved spectra of these SNRs, and to find significant frequency- and region-dependent spectral slope variations. For the first time, we provide direct evidence of a spectral break in the radio spectral energy distribution of W44 at an exponential cutoff frequency of 15 ± 2 GHz. This result constrains the maximum energy of the accelerated electrons in the range 6-13 GeV, in agreement with predictions indirectly derived from AGILE and Fermi-LAT gamma-ray observations. With regard to IC443, our results confirm the noticeable presence of a bump in the integrated spectrum around 20-70 GHz that could result from a spinning dust emission mechanism

SETI in Sardinia: status of scientific and technological developments

Since 2013, several staff members of the Cagliari Astronomical Observatory have been involved with SETI activities, both from a technological and a scientific perspective. One major asset related to this research area is the presence, in the territory, of one of the most modern single-dish antennas: the Sardinia Radio Telescope (SRT). In this paper, we outline all aspects of our initiatives in the framework of the Search for ExtraTerrestrial Intelligence. We describe the development of SRT instrumentation for the purpose of receiving data that could potentially contain signs of life, as well as the directions that we are investigating for studying and analyzing these data, including in an international context