Dislocations and cracks in generalized continua

Dislocations play a key role in the understanding of many phenomena in solid state physics, materials science, crystallography and engineering. Dislocations are line defects producing distortions and self-stresses in an otherwise perfect crystal lattice. In particular, dislocations are the primary carrier of crystal plasticity and in dislocation based fracture mechanics.Comment: arXiv admin note: text overlap with arXiv:1708.0529

Radial Corrugations of Multi-Walled Carbon Nanotubes Driven by Inter-Wall Nonbonding Interactions

We perform large-scale quasi-continuum simulations to determine the stable cross-sectional configurations of free-standing multi-walled carbon nanotubes (MWCNTs). We show that at an inter-wall spacing larger than the equilibrium distance set by the inter-wall van der Waals (vdW) interactions, the initial circular cross-sections of the MWCNTs are transformed into symmetric polygonal shapes or asymmetric water-drop-like shapes. Our simulations also show that removing several innermost walls causes even more drastic cross-sectional polygonization of the MWCNTs. The predicted cross-sectional configurations agree with prior experimental observations. We attribute the radial corrugations to the compressive stresses induced by the excessive inter-wall vdW energy release of the MWCNTs. The stable cross-sectional configurations provide fundamental guidance to the design of single MWCNT-based devices and shed lights on the mechanical control of electrical properties

Prenatal and Perinatal Risk Factors for Autism in China

We conducted a case–control study using 190 Han children with and without autism to investigate prenatal and perinatal risk factors for autism in China. Cases were recruited through public special education schools and controls from regular public schools in the same region (Tianjin), with frequency matching on sex and birth year. Unadjusted analyses identified seven prenatal and seven perinatal risk factors significantly associated with autism. In the adjusted analysis, nine risk factors showed significant association with autism: maternal second-hand smoke exposure, maternal chronic or acute medical conditions unrelated to pregnancy, maternal unhappy emotional state, gestational complications, edema, abnormal gestational age (<35 or >42 weeks), nuchal cord, gravidity >1, and advanced paternal age at delivery (>30 year-old)

Pan-cancer analysis of whole genomes

Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale(1-3). Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4-5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter(4); identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation(5,6); analyses timings and patterns of tumour evolution(7); describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity(8,9); and evaluates a range of more-specialized features of cancer genomes(8,10-18).Peer reviewe

A simplified metaelastic model for coated sphere-filled random composites

A simplified metaelastic model is presented to study long-wavelength dynamics of random composites filled with coated rigid spheres under the condition that the characteristic wavelength of the displacement field is much larger than the average distance between adjacent coated rigid spheres. The model is characterized by a simple differential relation between the displacement field of the composite and the displacement field of the mass center of a representative unit cell. The validity and accuracy of the model are demonstrated by comparing its predicted bandgap frequencies with known numerical and experimental data. The efficiency and merits of the model are demonstrated by applying it to study vibration isolation of coated rigid sphere-filled composite rods and (periodic or non-periodic) free vibration caused by initial displacement or velocity disturbance of the embedded rigid spheres inside an otherwise static composite rod. The proposed model could offer a simple method to study various long-wavelength metaelastic dynamic problems of coated rigid sphere-filled random composites. </jats:p

Adhesion of an elastic sphere on a tensioned membrane

Inspirited by the fact that classical models of adhesion contact (such as the Johnson–Kendall–Roberts model, Young’s equation or the Neumann equation) cannot be directly applied to adhesion of an elastic sphere on a membrane, the present work aims to develop an explicit general model for axisymmetric adhesion mechanics of an elastic sphere on a tensioned circular membrane. An explicit expression for the potential energy of the sphere–membrane system is derived, and explicit equations are given to determine the adhesion equilibrium state. The validity and accuracy of the proposed model are verified by good agreement between the predicted results and known results on both adhesion of a rigid sphere on a membrane and the critical condition for full wrapping of a rigid sphere by a membrane of non-zero bending rigidity. </jats:p

Towards integral inequalities of surface deformation in two-dimensional linear elasticity

This work is inspired to achieve an integral inequality for a linear elastic body in which the surface integral of squares of surface strains or surface displacement gradients is bounded from above by surface integral of squares of boundary tractions with a finite bound constant independent of boundary tractions. Here, all candidate displacements of the proposed variational quotients are required to meet the equations of equilibrium without body forces, and the boundary tractions are defined based on the displacements. Detailed results are given for two-dimensional anti-plane shear and plane-strain of circular domains, which confirm that the integral of surface strains or surface displacement gradients can be bounded from above by the integral of boundary tractions. </jats:p

Glial cells and chronic pain.

Over the past few years, the control of pain exerted by glial cells has emerged as a promising target against pathological pain. Indeed, changes in glial phenotypes have been reported throughout the entire nociceptive pathway, from peripheral nerves to higher integrative brain regions, and pharmacological inhibition of such glial reactions reduces the manifestation of pain in animal models. This complex interplay between glia and neurons relies on various mechanisms depending both on glial cell types considered (astrocytes, microglia, satellite cells, or Schwann cells), the anatomical location of the regulatory process (peripheral nerve, spinal cord, or brain), and the nature of the chronic pain paradigm. Intracellularly, recent advances have pointed to the activation of specific cascades, such as mitogen-associated protein kinases (MAPKs) in the underlying processes behind glial activation. In addition, given the large number of functions accomplished by glial cells, various mechanisms might sensitize nociceptive neurons including a release of pronociceptive cytokines and neurotrophins or changes in neurotransmitter-scavenging capacity. The authors review the conceptual advances made in the recent years about the implication of central and peripheral glia in animal models of chronic pain and discuss the possibility to translate it into human therapies in the future

A simple approach to solve boundary-value problems in gradient elasticity

We outline a procedure for obtaining solutions of certain boundary value problems of a recently proposed theory of gradient elasticity in terms of solutions of classical elasticity. The method is applied to illustrate, among other things, how the gradient theory can remove the strain singularity from some typical examples of the classical theory