Incommensurate magnetic ordering in Cu2Te2O5X2 (X=Cl, Br) studied by single crystal neutron diffraction

Polarized and unpolarized neutron diffraction studies have been carried out on single crystals of the coupled spin tetrahedra systems Cu2Te2O5X2 (X=Cl, Br). A model of the magnetic structure associated with the propagation vectors k'Cl ~ -0.150,0.422,1/2 and k'Br ~ -0.172,0.356,1/2 and stable below TN=18 K for X=Cl and TN=11 K for X=Br is proposed. A feature of the model, common to both the bromide and chloride, is a canted coplanar motif for the 4 Cu2+ spins on each tetrahedron which rotates on a helix from cell to cell following the propagation vector. The Cu2+magnetic moment determined for X=Br, 0.395(5)muB, is significantly less than for X=Cl, 0.88(1)muB at 2K. The magnetic structure of the chloride associated with the wave-vector k' differs from that determined previously for the wave vector k~0.150,0.422,1/2 [O. Zaharko et.al. Phys. Rev. Lett. 93, 217206 (2004)]

Status of ITER neutral beam cell remote handling system

The ITER neutral beam cell will contain up to three heating neutral beams and one diagnostic neutral beam, and four upper ports. Though manual maintenance work is envisaged within the cell, when containment is breached, or the radiological protection is removed the maintenance must be conducted remotely. This maintenance constitutes the removal and replacement of line replaceable units, and their transport to and from a cask docked to the cell. A design of the remote handling system has been prepared to concept level which this paper describes including the development of a beam line transporter, beam source remote handling equipment, upper port remote handling equipment and equipment for the maintenance of the neutral shield. This equipment has been developed complete the planned maintenance tasks for the components of the neutral beam cell and to have inherent flexibility to enable as yet unforeseen tasks and recovery operations to be performed.Comment: 4 pages, 9 figure

Probing the properties of convective cores through g modes: high-order g modes in SPB and gamma Doradus stars

In main sequence stars the periods of high-order gravity modes are sensitive probes of stellar cores and, in particular, of the chemical composition gradient that develops near the outer edge of the convective core. We present an analytical approximation of high-order g modes that takes into account the effect of the mu gradient near the core. We show that in main-sequence models, similarly to the case of white dwarfs, the periods of high-order gravity modes are accurately described by a uniform period spacing superposed to an oscillatory component. The periodicity and amplitude of such component are related, respectively, to the location and sharpness of the mu gradient. We investigate the properties of high-order gravity modes for stellar models in a mass domain between 1 and 10 Msun, and the effects of the stellar mass, evolutionary state, and extra-mixing processes on period spacing features. In particular, we show that for models of a typical SPB star, a chemical mixing that could likely be induced by the slow rotation observed in these stars, is able to significantly change the g-mode spectra of the equilibrium model. Prospects and challenges for the asteroseismology of gamma Doradus and SPB stars are also discussed.Comment: 18 pages, 29 figures, accepted for publication in MNRA

Effects of empagliflozin on blood pressure and markers of arterial stiffness and vascular resistance in patients with type 2 diabetes

Peer reviewe

Measurement of Muon Capture on the Proton to 1% Precision and Determination of the Pseudoscalar Coupling g_P

The MuCap experiment at the Paul Scherrer Institute has measured the rate L_S of muon capture from the singlet state of the muonic hydrogen atom to a precision of 1%. A muon beam was stopped in a time projection chamber filled with 10-bar, ultra-pure hydrogen gas. Cylindrical wire chambers and a segmented scintillator barrel detected electrons from muon decay. L_S is determined from the difference between the mu- disappearance rate in hydrogen and the free muon decay rate. The result is based on the analysis of 1.2 10^10 mu- decays, from which we extract the capture rate L_S = (714.9 +- 5.4(stat) +- 5.1(syst)) s^-1 and derive the proton's pseudoscalar coupling g_P(q^2_0 = -0.88 m^2_mu) = 8.06 +- 0.55.Comment: Updated figure 1 and small changes in wording to match published versio

Structural basis for high-affinity binding of LEDGF PWWP to mononucleosomes

Lens epithelium-derived growth factor (LEDGF/p75) tethers lentiviral preintegration complexes (PICs) to chromatin and is essential for effective HIV-1 replication. LEDGF/p75 interactions with lentiviral integrases are well characterized, but the structural basis for how LEDGF/p75 engages chromatin is unknown. We demonstrate that cellular LEDGF/p75 is tightly bound to mononucleosomes (MNs). Our proteomic experiments indicate that this interaction is direct and not mediated by other cellular factors. We determined the solution structure of LEDGF PWWP and monitored binding to the histone H3 tail containing trimethylated Lys36 (H3K36me3) and DNA by NMR. Results reveal two distinct functional interfaces of LEDGF PWWP: a well-defined hydrophobic cavity, which selectively interacts with the H3K36me3 peptide and adjacent basic surface, which non-specifically binds DNA. LEDGF PWWP exhibits nanomolar binding affinity to purified native MNs, but displays markedly lower affinities for the isolated H3K36me3 peptide and DNA. Furthermore, we show that LEDGF PWWP preferentially and tightly binds to in vitro reconstituted MNs containing a tri-methyl-lysine analogue at position 36 of H3 and not to their unmodified counterparts. We conclude that cooperative binding of the hydrophobic cavity and basic surface to the cognate histone peptide and DNA wrapped in MNs is essential for high-affinity binding to chromatin

Asteroseismology of the Beta Cephei star 12 (DD) Lacertae: photometric observations, pulsational frequency analysis and mode identification

We report a multisite photometric campaign for the Beta Cephei star 12 Lacertae. 750 hours of high-quality differential photoelectric Stromgren, Johnson and Geneva time-series photometry were obtained with 9 telescopes during 190 nights. Our frequency analysis results in the detection of 23 sinusoidal signals in the light curves. Eleven of those correspond to independent pulsation modes, and the remainder are combination frequencies. We find some slow aperiodic variability such as that seemingly present in several Beta Cephei stars. We perform mode identification from our colour photometry, derive the spherical degree l for the five strongest modes unambiguously and provide constraints on l for the weaker modes. We find a mixture of modes of 0 <= l <= 4. In particular, we prove that the previously suspected rotationally split triplet within the modes of 12 Lac consists of modes of different l; their equal frequency splitting must thus be accidental. One of the periodic signals we detected in the light curves is argued to be a linearly stable mode excited to visible amplitude by nonlinear mode coupling via a 2:1 resonance. We also find a low-frequency signal in the light variations whose physical nature is unclear; it could be a parent or daughter mode resonantly coupled. The remaining combination frequencies are consistent with simple light-curve distortions. The range of excited pulsation frequencies of 12 Lac may be sufficiently large that it cannot be reproduced by standard models. We suspect that the star has a larger metal abundance in the pulsational driving zone, a hypothesis also capable of explaining the presence of Beta Cephei stars in the LMC.Comment: 12 pages, 7 figures, MNRAS, in pres

Early human B cell response to Ebola virus in four U.S. survivors of infection

The human B cell response to natural filovirus infections early after recovery is poorly understood. Previous serologic studies suggest that some Ebola virus survivors exhibit delayed antibody responses with low magnitude and quality. Here, we sought to study the population of individual memory B cells induced early in convalescence. We isolated monoclonal antibodies (MAbs) from memory B cells from four survivors treated for Ebola virus disease (EVD) 1 or 3 months after discharge from the hospital. At the early time points postrecovery, the frequency of Ebola-specific B cells was low and dominated by clones that were cross-reactive with both Ebola glycoprotein (GP) and with the secreted GP (sGP) form. Of 25 MAbs isolated from four donors, only one exhibited neutralization activity. This neutralizing MAb, designated MAb EBOV237, recognizes an epitope in the glycan cap of the surface glycoprotein. In vivo murine lethal challenge studies showed that EBOV237 conferred protection when given prophylactically at a level similar to that of the ZMapp component MAb 13C6. The results suggest that the human B cell response to EVD 1 to 3 months postdischarge is characterized by a paucity of broad or potent neutralizing clones. However, the neutralizing epitope in the glycan cap recognized by EBOV237 may play a role in the early human antibody response to EVD and should be considered in rational design strategies for new Ebola virus vaccine candidates