Identification of Hazard and Risk for Glacial Lakes in the Nepal Himalaya Using Satellite Imagery from 2000–2015

Glacial lakes in the Nepal Himalaya can threaten downstream communities and have large socio-economic consequences if an outburst flood occurs. This study identified 131 glacial lakes in Nepal in 2015 that are greater than 0.1 km ²and performed a first-pass hazard and risk assessment for each lake. The hazard assessment included mass entering the lake, the moraine stability, and how lake expansion will alter the lake’s hazard in the next 15–30 years. A geometric flood model was used to quantify potential hydropower systems, buildings, agricultural land, and bridges that could be affected by a glacial lake outburst flood. The hazard and downstream impacts were combined to classify the risk associated with each lake. 11 lakes were classified as very high risk and 31 as high risk. The potential flood volume was also estimated and used to prioritize the glacial lakes that are the highest risk, which included Phoksundo Tal, Tsho Rolpa, Chamlang North Tsho, Chamlang South Tsho, and Lumding Tsho. These results are intended to assist stakeholders and decision makers in making well-informed decisions with respect to the glacial lakes that should be the focus of future field studies, modeling efforts, and risk-mitigation actions

Atmospheric effects and spurious signals in GPS analyses

Improvements in the analyses of Global Positioning System (GPS) observations yield resolvable millimeter to submillimeter differences in coordinate estimates, thus providing sufficient resolution to distinguish subtle differences in analysis methodologies. Here we investigate the effects on site coordinates of using different approaches to modeling atmospheric loading deformation (ATML) and handling of tropospheric delays. The rigorous approach of using the time-varying Vienna Mapping Function 1 yields solutions with lower noise at a range of frequencies compared with solutions generated using empirical mapping functions. This is particularly evident when ATML is accounted for. Some improvement also arises from using improved a priori zenith hydrostatic delays (ZHD), with the combined effect being site-specific. Importantly, inadequacies in both mapping functions and a priori ZHDs not only introduce time-correlated noise but significant periodic terms at solar annual and semiannual periods. We find no significant difference between solutions where nontidal ATML is applied at the observation level rather than as a daily averaged value, but failing to model diurnal and semidiurnal tidal ATML at the observation level can introduce anomalous propagated signals with periods that closely match the GPS draconitic annual (351.4 days) and semiannual period (175.7 days). Exacerbated by not fixing ambiguities, these signals are evident in both stacked and single-site power spectra, with each tide contributing roughly equally to the dominant semiannual peak. The amplitude of the propagated signal reaches a maximum of 0.8 mm with a clear latitudinal dependence that is not correlated directly with locations of maximum tidal amplitude

The early life microbiota protects neonatal mice from pathological small intestinal epithelial cell shedding

The early life gut microbiota plays a crucial role in regulating and maintaining the intestinal barrier, with disturbances in these communities linked to dysregulated renewal and replenishment of intestinal epithelial cells. Here we sought to determine pathological cell shedding outcomes throughout the postnatal developmental period, and which host and microbial factors mediate these responses. Surprisingly, neonatal mice (Day 14 and 21) were highly refractory to induction of cell shedding after intraperitoneal administration of liposaccharide (LPS), with Day 29 mice showing strong pathological responses, more similar to those observed in adult mice. These differential responses were not linked to defects in the cellular mechanisms and pathways known to regulate cell shedding responses. When we profiled microbiota and metabolites, we observed significant alterations. Neonatal mice had high relative abundances of Streptococcus, Escherichia, and Enterococcus and increased primary bile acids. In contrast, older mice were dominated by Candidatus Arthromitus, Alistipes, and Lachnoclostridium, and had increased concentrations of SCFAs and methyamines. Antibiotic treatment of neonates restored LPS-induced small intestinal cell shedding, whereas adult fecal microbiota transplant alone had no effect. Our findings further support the importance of the early life window for microbiota-epithelial interactions in the presence of inflammatory stimuli and highlights areas for further investigation

On the massive gluon propagator, the PT-BFM scheme and the low-momentum behaviour of decoupling and scaling DSE solutions

We study the low-momentum behaviour of Yang-Mills propagators obtained from Landau-gauge Dyson-Schwinger equations (DSE) in the PT-BFM scheme. We compare the ghost propagator numerical results with the analytical ones obtained by analyzing the low-momentum behaviour of the ghost propagator DSE in Landau gauge, assuming for the truncation a constant ghost-gluon vertex and a simple model for a massive gluon propagator. The asymptotic expression obtained for the regular or decoupling ghost dressing function up to the order ${\cal O}(q^2)$ is proven to fit pretty well the numerical PT-BFM results. Furthermore, when the size of the coupling renormalized at some scale approaches some critical value, the numerical PT-BFM propagators tend to behave as the scaling ones. We also show that the scaling solution, implying a diverging ghost dressing function, cannot be a DSE solution in the PT-BFM scheme but an unattainable limiting case.Comment: 16 pages, 2 figs., 2 tabs (updated version to be published in JHEP

Fit for the future? The place of global health in the UK's postgraduate medical training: a review.

OBJECTIVES: That health is now global is increasingly accepted. However, a 'mismatch between present professional competencies and the requirements of an increasingly interdependent world' has been identified. Postgraduate training should take account of the increasingly global nature of health; this paper examines the extent to which they currently do. DESIGN: Trainees across 11 medical specialties reviewed the content of their postgraduate curriculum. SETTING: Not relevant. PARTCIPANTS: None. MAIN OUTCOME MEASURES: Competencies were coded as 'UK' (statement only relevant to UK work), 'global' (statement with an explicit reference to aspects of health outside the UK) or generic (relevant both to the UK and international settings). RESULTS: Six of the 11 curricula reviewed contained global health competencies. These covered the global burden or determinants of disease and appropriate policy responses. Only one College required trainees to 'be aware of the World Health Organization', or 'know the local, national and international structures for health care'. These cross-cutting competencies have applicability to all specialties. All 11 curricula contained generic competencies where a global health perspective and/or experience could be advantageous, e.g. caring for migrant or culturally different patients. CONCLUSION: Trainees in all specialties should achieve a minimum requirement of global health awareness. This can be achieved through a small number of common competencies that are consistent across core curricula. These should lead on from equivalent undergraduate competencies. Addressing the current gap in the global health content of postgraduate medical curricula will ensure that the UK has health professionals that are trained to meet the health challenges of the future