Radiative Two Loop Inverse Seesaw and Dark Matter

Seesaw mechanism provides a natural explanation of light neutrino masses through suppression of heavy seesaw scale. In inverse seesaw models the seesaw scale can be much lower than that in the usual seesaw models. If terms inducing seesaw masses are further induced by loop corrections, the seesaw scale can be lowered to be in the range probed by experiments at the LHC without fine tuning. In this paper we construct models in which inverse seesaw neutrino masses are generated at two loop level. These models also naturally have dark matter candidates. Although the recent data from Xenon100 put stringent constraint on the models, they can be consistent with data on neutrino masses, mixing, dark matter relic density and direct detection. These models also have some interesting experimental signatures for collider and flavor physics.Comment: RevTex 14 pages 3 figures. Several references adde

The modular systems biology approach to investigate the control of apoptosis in Alzheimer's disease neurodegeneration

Apoptosis is a programmed cell death that plays a critical role during the development of the nervous system and in many chronic neurodegenerative diseases, including Alzheimer's disease (AD). This pathology, characterized by a progressive degeneration of cholinergic function resulting in a remarkable cognitive decline, is the most common form of dementia with high social and economic impact. Current therapies of AD are only symptomatic, therefore the need to elucidate the mechanisms underlying the onset and progression of the disease is surely needed in order to develop effective pharmacological therapies. Because of its pivotal role in neuronal cell death, apoptosis has been considered one of the most appealing therapeutic targets, however, due to the complexity of the molecular mechanisms involving the various triggering events and the many signaling cascades leading to cell death, a comprehensive understanding of this process is still lacking. Modular systems biology is a very effective strategy in organizing information about complex biological processes and deriving modular and mathematical models that greatly simplify the identification of key steps of a given process. This review aims at describing the main steps underlying the strategy of modular systems biology and briefly summarizes how this approach has been successfully applied for cell cycle studies. Moreover, after giving an overview of the many molecular mechanisms underlying apoptosis in AD, we present both a modular and a molecular model of neuronal apoptosis that suggest new insights on neuroprotection for this disease

A Unique Magnetic Resonance Imaging Feature of Glioblastoma Multiforme: The ‘Pseudopalisade’ Sign

This study was designed to investigate the unique magnetic resonance imaging (MRI) appearance of histopathologically-proven glioblastoma multiforme (GBM) with pseudopalisade necrosis and to assess its value for grading gliomas and providing a differential diagnosis. The study included 169 patients with intracranial masses who underwent surgery and had a proven histopathological diagnosis: 50 with GBM, 77 with gliomas (46 grade II and 31 grade III) and 42 with other intracranial masses (20 metastases, 14 lymphomas and eight abscesses). All patients underwent pre-operative brain MRI including post-contrast T1-weighted imaging. The presence of the ‘pseudopalisade’ sign on post-contrast T1-weighted images was compared among the different types of brain mass. The frequency of the ‘pseudopalisade’ sign in GBMs (94.00%) was significantly higher than that seen in grade II and III gliomas (11.69%) and other intracranial masses (7.14%). The ‘pseudopalisade’ sign on post-contrast T1-weighted images was useful for grading gliomas and for differentiating GBM from other brain masses. </jats:p