(1S)-1-phenylethanaminium 4-{[(1S,2S)-1-hydroxy-2,3-dihydro-1H,1'H-[2,2'-biinden]-2-yl]methyl}benzoate

Copyright 2012 © International Union of Crystallography.The title molecular salt, C8H12N+·C26H21O3-, contains a dimeric indane pharmacophore that demonstrates potent anti-inflammatory activity. The indane group of the anion exhibits some disorder about the [alpha]-C atom, which appears common to many structures containing this group. A model to account for the slight disorder was attempted, but this was deemed unsuccessful because applying bond-length constraints to all the bonds about the [alpha]-C atom led to instability in the refinement. The absolute configuration was determined crystallographically as S,S,S by anomalous dispersion methods with reference to both the Flack parameter and Bayesian statistics on Bijvoet differences. The configuration was also determined by an a priori knowledge of the absolute configuration of the (1S)-1-phenylethanaminium counter-ion. The molecules pack in the crystal structure to form an infinite two-dimensional hydrogen-bond network in the (100) plane of the unit cell

Cloud feedback mechanisms and their representation in global climate models

Cloud feedback – the change in top-of-atmosphere radiative flux resulting from the cloud response to warming – constitutes by far the largest source of uncertainty in the climate response to CO2 forcing simulated by global climate models (GCMs). We review the main mechanisms for cloud feedbacks, and discuss their representation in climate models and the sources of inter-model spread. Global-mean cloud feedback in GCMs results from three main effects: (1) rising free- tropospheric clouds (a positive longwave effect); (2) decreasing tropical low cloud amount (a positive shortwave effect); (3) increasing high-latitude low cloud optical depth (a negative shortwave effect). These cloud responses simulated by GCMs are qualitatively supported by theory, high-resolution modeling, and observations. Rising high clouds are consistent with the Fixed Anvil Temperature (FAT) hypothesis, whereby enhanced upper-tropospheric radiative cooling causes anvil cloud tops to remain at a nearly fixed temperature as the atmosphere warms. Tropical low cloud amount decreases are driven by a delicate balance between the effects of vertical turbulent fluxes, radiative cooling, large-scale subsidence, and lower-tropospheric stability on the boundary-layer moisture budget. High-latitude low cloud optical depth increases are dominated by phase changes in mixed- phase clouds. The causes of inter-model spread in cloud feedback are discussed, focusing particularly on the role of unresolved parameterized processes such as cloud microphysics, turbulence, and convection

Enumeration of distinct mechanically stable disk packings in small systems

We create mechanically stable (MS) packings of bidisperse disks using an algorithm in which we successively grow or shrink soft repulsive disks followed by energy minimization until the overlaps are vanishingly small. We focus on small systems because this enables us to enumerate nearly all distinct MS packings. We measure the probability to obtain a MS packing at packing fraction $\phi$ and find several notable results. First, the probability is highly nonuniform. When averaged over narrow packing fraction intervals, the most probable MS packing occurs at the highest $\phi$ and the probability decays exponentially with decreasing $\phi$. Even more striking, within each packing-fraction interval, the probability can vary by many orders of magnitude. By using two different packing-generation protocols, we show that these results are robust and the packing frequencies do not change qualitatively with different protocols.Comment: 4 pages, 3 figures, Conference Proceedings for X International Workshop on Disordered System

Problem Specific MOEA/D for Barrier Coverage with Wireless Sensors

Barrier coverage with wireless sensors aims at detecting intruders who attempt to cross a specific area, where wireless sensors are distributed remotely at random. This paper considers limited-power sensors with adjustable ranges deployed along a linear domain to form a barrier to detect intruding incidents. We introduce three objectives to minimize: 1) total power consumption while satisfying full coverage; 2) the number of active sensors to improve the reliability; and 3) the active sensor nodes' maximum sensing range to maintain fairness. We refer to the problem as the tradeoff barrier coverage (TBC) problem. With the aim of obtaining a better tradeoff among the three objectives, we present a multiobjective optimization framework based on multiobjective evolutionary algorithm (MOEA)/D, which is called problem specific MOEA/D (PS-MOEA/D). Specifically, we define a 2-tuple encoding scheme and introduce a cover-shrink algorithm to produce feasible and relatively optimal solutions. Subsequently, we incorporate problem-specific knowledge into local search, which allows search procedures for neighboring subproblems collaborate each other. By considering the problem characteristics, we analyze the complexity and incorporate a strategy of computational resource allocation into our algorithm. We validate our approach by comparing with four competitors through several most-used metrics. The experimental results demonstrate that PS-MOEA/D is effective and outperforms the four competitors in all the cases, which indicates that our approach is promising in dealing with TBC

An increased prevalence of self-reported allergic rhinitis in major Chinese cities from 2005 to 2011

Background: The prevalence of allergic rhinitis (AR) has increased worldwide in recent decades. This study was conducted to investigate the prevalence of self-reported AR and profiles of AR-related comorbidities in the adult population of China over time. Methods: This study surveyed residents of 18 major cities in mainland China. Telephone interviews were conducted with study participants after sampling target telephone numbers by random digit dialing. The questions asked during telephone interviews were based on those included in validated questionnaires and focused on topics regarding AR, nonallergic rhinitis (NAR), acute/chronic rhinosinusitis (ARS/CRS), asthma, and atopic dermatitis (AD). Results: During 2011, a total of 47216 telephone interviews were conducted, and the overall response rate was 77.5%. When compared with the AR prevalence in 11 cities surveyed in 2005, there was a significant increase in self-reported adult AR in eight of those cities (P<0.01). In 2011, the standardized prevalence of self-reported adult AR in the 18 cities was 17.6%. The concentration of SO2 was positively correlated with the prevalence of AR (r=0.504, P=0.033). A multiple regression model showed that the absolute change in household yearly income was significantly associated with the change in the prevalence of AR (R-2=0.68), after adjusting for PM10, SO2, NO2, temperature, and humidity. The overall prevalences of NAR, ARS, CRS, asthma, and AD in the general population were 16.4%, 5.4%, 2.1%, 5.8%, and 14%, respectively. Conclusion: During a 6-year period, there was a significant increase in the prevalence of self-reported AR in the general Chinese adult population. The incidence of AR being accompanied by rhinosinusitis, asthma, or AD was significantly higher among individuals having self-reported AR compared with the general population

International diversification with factor funds

We propose a new investment strategy employing "factor funds" to systematically enhance the meanvariance efficiency of international diversification. Our approach is motivated by the increasing evidence that size (SMB), book-to-market (HML), and momentum (MOM) factors, along with the market factor, adequately describe international stock returns, and by the direct link between investors' portfolio choice problems and international asset pricing theories and tests. Using data from 10 developed countries during the period 1981-2008, we show that the "augmented" optimal portfolio involving local factor funds substantially outperforms the "benchmark" optimal portfolio comprising country market indices only as measured by their portfolio Sharpe ratios. This strongly rejects the intersection hypothesis which posits that the local factor funds do not span investment opportunities beyond what country market indices do. Among the three classes of factor funds, HML funds contribute most to the efficiency gains. In addition, the local version of factor funds outperforms the global factor funds. The added gains from local factor diversification are significant for both in-sample and out-of-sample periods, and for a realistic range of additional investment costs for factor funds, and remain robust over time. Copyright © 2010 INFORMS.preprin

Three-dimensionally Ordered Macroporous Structure Enabled Nanothermite Membrane of Mn2O3/Al

Mn2O3 has been selected to realize nanothermite membrane for the first time in the literature. Mn2O3/Al nanothermite has been synthesized by magnetron sputtering a layer of Al film onto three-dimensionally ordered macroporous (3DOM) Mn2O3 skeleton. The energy release is significantly enhanced owing to the unusual 3DOM structure, which ensures Al and Mn2O3 to integrate compactly in nanoscale and greatly increase effective contact area. The morphology and DSC curve of the nanothermite membrane have been investigated at various aluminizing times. At the optimized aluminizing time of 30 min, energy release reaches a maximum of 2.09 kJ∙g−1, where the Al layer thickness plays a decisive role in the total energy release. This method possesses advantages of high compatibility with MEMS and can be applied to other nanothermite systems easily, which will make great contribution to little-known nanothermite research

What is nursing? A phenomenological analysis of the characteristics of Chinese nursing

2003-2004 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe