Perturbations of Gauss-Bonnet Black Strings in Codimension-2 Braneworlds

We derive the Lichnerowicz equation in the presence of the Gauss-Bonnet term. Using the modified Lichnerowicz equation we study the metric perturbations of Gauss-Bonnet black strings in Codimension-2 Braneworlds.Comment: 26 pages, no figures, clarifying comments and one reference added, to be published in JHE

Predicting optical coherence tomography-derived diabetic macular edema grades from fundus photographs using deep learning

Diabetic eye disease is one of the fastest growing causes of preventable blindness. With the advent of anti-VEGF (vascular endothelial growth factor) therapies, it has become increasingly important to detect center-involved diabetic macular edema (ci-DME). However, center-involved diabetic macular edema is diagnosed using optical coherence tomography (OCT), which is not generally available at screening sites because of cost and workflow constraints. Instead, screening programs rely on the detection of hard exudates in color fundus photographs as a proxy for DME, often resulting in high false positive or false negative calls. To improve the accuracy of DME screening, we trained a deep learning model to use color fundus photographs to predict ci-DME. Our model had an ROC-AUC of 0.89 (95% CI: 0.87-0.91), which corresponds to a sensitivity of 85% at a specificity of 80%. In comparison, three retinal specialists had similar sensitivities (82-85%), but only half the specificity (45-50%, p<0.001 for each comparison with model). The positive predictive value (PPV) of the model was 61% (95% CI: 56-66%), approximately double the 36-38% by the retinal specialists. In addition to predicting ci-DME, our model was able to detect the presence of intraretinal fluid with an AUC of 0.81 (95% CI: 0.81-0.86) and subretinal fluid with an AUC of 0.88 (95% CI: 0.85-0.91). The ability of deep learning algorithms to make clinically relevant predictions that generally require sophisticated 3D-imaging equipment from simple 2D images has broad relevance to many other applications in medical imaging

Shortcuts in a Nonlinear Dynamical Braneworld in Six Dimensions

We consider a dynamical brane world in a six-dimensional spacetime containing a singularity. Using the Israel conditions we study the motion of a 4-brane embedded in this setup. We analyse the brane behaviour when its position is perturbed about a fixed point and solve the full nonlinear dynamics in the several possible scenarios. We also investigate the possible gravitational shortcuts and calculate the delay between graviton and photon signals and the ratio of the corresponding subtended horizons.Comment: 26 pages, 9 figures. References and discussion added. Title changed to match the version accepted in Class. and Quant. Gra

Thermal one- and two-graviton Green's functions in the temporal gauge

The thermal one- and two-graviton Green's function are computed using a temporal gauge. In order to handle the extra poles which are present in the propagator, we employ an ambiguity-free technique in the imaginary-time formalism. For temperatures T high compared with the external momentum, we obtain the leading T^4 as well as the subleading T^2 and log(T) contributions to the graviton self-energy. The gauge fixing independence of the leading T^4 terms as well as the Ward identity relating the self-energy with the one-point function are explicitly verified. We also verify the 't Hooft identities for the subleading T^2 terms and show that the logarithmic part has the same structure as the residue of the ultraviolet pole of the zero temperature graviton self-energy. We explicitly compute the extra terms generated by the prescription poles and verify that they do not change the behavior of the leading and sub-leading contributions from the hard thermal loop region. We discuss the modification of the solutions of the dispersion relations in the graviton plasma induced by the subleading T^2 contributions.Comment: 17 pages, 5 figures. Revised version to be published in Phys. Rev.

The shortest cut in brane cosmology

We consider brane cosmology studying the shortest null path on the brane for photons, and in the bulk for gravitons. We derive the differential equation for the shortest path in the bulk for a 1+4 cosmological metric. The time cost and the redshifts for photons and gravitons after traveling their respective path are compared. We consider some numerical solutions of the shortest path equation, and show that there is no shortest path in the bulk for the Randall-Sundrum vacuum brane solution, the linear cosmological solution of Bin\'etruy, et al for $\omega = -1, -{2/3}$, and for some expanding brane universes.Comment: 20 pages, 7 figure

Preparation of anti-vicinal amino alcohols: asymmetric synthesis of D-erythro-Sphinganine, (+)-spisulosine and D-ribo-phytosphingosine

Two variations of the Overman rearrangement have been developed for the highly selective synthesis of anti-vicinal amino alcohol natural products. A MOM-ether directed palladium(II)-catalyzed rearrangement of an allylic trichloroacetimidate was used as the key step for the preparation of the protein kinase C inhibitor D-erythro-sphinganine and the antitumor agent (+)-spisulosine, while the Overman rearrangement of chiral allylic trichloroacetimidates generated by asymmetric reduction of an alpha,beta-unsaturated methyl ketone allowed rapid access to both D-ribo-phytosphingosine and L-arabino-phytosphingosine

Geodesics, the Equivalence Principle and Singularities in Higher-dimensional General Relativity and Braneworlds

The geodesics of a spacetime seldom coincide with those of an embedded submanifold of codimension one. We investigate this issue for higher-dimensional general relativity-like models, firstly in the simpler case without branes to isolate which features are already present, and then in the more complicated case with branes. The framework in which we consider branes is general enough to include asymmetric braneworlds but not thick branes. We apply our results on geodesics to study both the equivalence principle and cosmological singularities. Among the models we study these considerations favour $Z_2$ symmetric braneworlds with a negative bulk cosmological constant.Comment: 20 pages, 2 figures. Accepted by JCAP. Minor proofreading corrections; several references adde

Instability of brane cosmological solutions with flux compactifications

We discuss the stability of the higher-dimensional de Sitter (dS) brane solutions with two-dimensional internal space in the Einstein-Maxwel theory. We show that an instability appears in the scalar-type perturbations with respect to the dS spacetime. We derive a differential relation which has the very similar structure to the ordinary laws of thermodynamics as an extension of the work for the six-dimensional model [20]. In this relation, the area of dS horizon (integrated over the two internal dimensions) exactly behaves as the thermodynamical entropy. The dynamically unstable solutions are in the thermodynamically unstable branch. An unstable dS compactification either evolves toward a stable configuration or two-dimensional internal space is decompactified. These dS brane solutions are equivalent to the accelerating cosmological solutions in the six-dimensional Einstein-Maxwell-dilaton theory via dimensional reduction. Thus, if the seed higher-dimensional solution is unstable, the corresponding six-dimensional solution is also unstable. From the effective four-dimensional point of view, a cosmological evolution from an unstable cosmological solution in higher dimensions may be seen as a process of the transition from the initial cosmological inflation to the current dark energy dominated Universe.Comment: 11 pages, 3 figures, references added, to appear in CQ