Investigation of the effect of pressure on metallurgical phenomena Final report, 20 Jun. 1960 - 30 Sep. 1965

Pressure effect on lead-thallium, tin telluride, and lead tellurid

Pharmacokinetics of FK506 in liver transplant recipients after continuous intravenous infusion

The first-dose pharmacokinetics of FK506 was studied in nine orthotopic liver transplant patients receiving continuous intravenous infusion of 0.15 mg/kg/day. Multiple blood samples were obtained during the infusion and plasma FK506 concentrations were measured by enzyme-linked immunosorbent assay. The plasma clearance ranged from 0.47 to 5.8 L/minute, and the half- life ranged from 4.5 hours to 33.1 hours. These results indicate the pharmacokinetics of FK506 to be highly variable between patients. FK506 is extensively distributed outside the plasma compartment. FK506 is extensively metabolized in the body, with less than 1% of the administered dose being excreted in the urine as unchanged FK506. The large variability in FK506 kinetics during the immediate postoperative period is attributed to the variability in the functional status of the liver in the transplant patients. Because of the long half-life of FK506, it takes more than 45 hours to reach steady-state concentrations after continuous infusion. Based on the estimated kinetic parameters, it appears that a combination of a bolus or a rapid infusion of .02 mg/kg with a continuous infusion of 0.05 mg/kg/day will provide and maintain a concentration of more than 2 ng/mL from the beginning of the drug treatment

Renal transplantation in baboons under FK 506

FK 506 was tested in unrelated baboons submitted to renal transplantation and bilateral native nephrectomy. Untreated baboons died after 9.2 ± 4.0 SD days. When FK 506 was given orally for 90 days, survival with the optimum dose was 74.6 ± 28.9 days; this allowed maximum credit for each individual animal of 90 days. A 3-day course of intramuscular FK 506 started on postoperative day 4 allowed 1- to 2-month survival. Delayed rejection in these baboons as well as in those treated daily for 90 days with FK could sometimes be reversed temporarily with a second 3-day course. The doses required for a good therapeutic effect were 10 times greater in baboons than in dogs, a finding that may reflect a species difference of lymphocyte sensitivity to this drug. FK appeared to be relatively nontoxic in subhuman primates, and it remains a promising drug for clinical trial. © 1989

Comparison of Carbide Coatings for Graphite Based Fuel Elements

In this report, several important factors which influence the selection of a coating material for use with graphite based fuel elements in a NERVA type reactor system are reviewed

Misdemeanor Enforcement Trends Across Seven U.S. Jurisdictions

This paper, which is a product of DCJ's Research Network on Misdemeanor Justice ("the Research Network"), examines long-term trends in lower-level enforcement across seven U.S. jurisdictions:  Durham, NC; Los Angeles, CA; Louisville, KY;  New York City, NY; Prince George's County; MD; Seattle, WA; and St. Louis, MO. It draws both on reports that were produced through partnerships between local researchers and criminal justice agency partners as well as updated data the Research Network has published through an interactive online dashboard. The paper analyzed cross-jurisdictional trends in enforcement, including misdemeanor arrest rates broadly, by demographics (race/age/sex), and by charge

Cryogenic mock-up loop design study

This report addresses the cryogenic mock-up loop design study