Structural and Functional Neuroimaging of Visual Hallucinations in Lewy Body Disease: A Systematic Literature Review.

Patients with Lewy body disease (LBD) frequently experience visual hallucinations (VH), well-formed images perceived without the presence of real stimuli. The structural and functional brain mechanisms underlying VH in LBD are still unclear. The present review summarises the current literature on the neural correlates of VH in LBD, namely Parkinson's disease (PD), and dementia with Lewy bodies (DLB). Following a systematic literature search, 56 neuroimaging studies of VH in PD and DLB were critically reviewed and evaluated for quality assessment. The main structural neuroimaging results on VH in LBD revealed grey matter loss in frontal areas in patients with dementia, and parietal and occipito-temporal regions in PD without dementia. Parietal and temporal hypometabolism was also reported in hallucinating PD patients. Disrupted functional connectivity was detected especially in the default mode network and fronto-parietal regions. However, evidence on structural and functional connectivity is still limited and requires further investigation. The current literature is in line with integrative models of VH suggesting a role of attention and perception deficits in the development of VH. However, despite the close relationship between VH and cognitive impairment, its associations with brain structure and function have been explored only by a limited number of studies

Production of bioethanol from multiple waste streams of rice milling

This work describes the feasibility of using rice milling by-products as feedstock for bioethanol. Starch-rich residues (rice bran, broken, unripe and discolored rice) were individually fermented (20% w/v) through Consolidated Bioprocessing by two industrial engineered yeast secreting fungal amylases. Rice husk (20% w/v), mainly composed by lignocellulose, was pre-treated at 55 degrees C with alkaline peroxide, saccharified through optimized dosages of commercial enzymes (Cellic (R) CTec2) and fermented by the recombinant strains. Finally, a blend of all the rice by-products, formulated as a mixture (20% w/v) according to their proportions at milling plants, were co-processed to ethanol by optimized pre-treatment, saccharification and fermentation by amylolytic strains. Fermenting efficiency for each by-product was high (above 88% of the theoretical) and further confirmed on the blend of residues (nearly 52 g/L ethanol). These results demonstrated for the first time that the co-conversion of multiple waste streams is a promising option for second generation ethanol production

Facing the future: Scanning, synthesizing and sense-making in horizon scanning

In this paper, we discuss key issues in harnessing horizon scanning to shape systemic policies, particularly in the light of the foresight exercise ‘Facing the future: Time for the EU to meet global challenges' which was carried out for the Bureau of European Policy Advisors. This exercise illustrates how horizon scanning can enable collective sense-making processes which assist in the identification of emerging signals and policy issues; the synthesis of such issues into encompassing clusters; and the interpretation of resulting clusters as an important step towards the coordinated development of joint policy measures. In order to achieve such objectives, horizon scanning can benefit from methods of multi-criteria decision-making and network analysis for prioritizing, clustering and combining issues. Furthermore, these methods provide support for traceability, which in turn contributes to the enhanced transparency and legitimacy of foresigh

Utilisation of wheat bran as a substrate for bioethanol production using recombinant cellulases and amylolytic yeast

Wheat bran, generated from the milling of wheat, represents a promising feedstock for the production of bioethanol. This substrate consists of three main components: starch, hemicellulose and cellulose. The optimal conditions for wheat bran hydrolysis have been determined using a recombinant cellulase cocktail (RCC), which contains two cellobiohydrolases, an endoglucanase and a beta-glucosidase. The 10% (w/v, expressed in terms of dry matter) substrate loading yielded the most glucose, while the 2% loading gave the best hydrolysis efficiency (degree of saccharification) using unmilled wheat bran. The ethanol production of two industrial amylolytic Saccharomyces cerevisiae strains, MEL2[TLG1-SFA1] and M2n [TLG1-SFA1], were compared in a simultaneous saccharification and fermentation (SSF) for 10% wheat bran loading with or without the supplementation of optimised RCC. The recombinant yeasts. cerevisiae MEL2[TLG1-SFA1] and M2n[TLG1-SFA1] completely hydrolysed wheat bran's starch producing similar amounts of ethanol (5.3 +/- 0.14 g/L and 5.0 +/- 0.09 g/L, respectively). Supplementing SSF with RCC resulted in additional ethanol production of about 2.0 g/L. Scanning electron microscopy confirmed the effectiveness of both RCC and engineered amylolytic strains in terms of cellulose and starch depolymerisatio

Single cell analysis reveals the involvement of the long non-coding RNA Pvt1 in the modulation of muscle atrophy and mitochondrial network

Long non-coding RNAs (lncRNAs) are emerging as important players in the regulation of several aspects of cellular biology. For a better comprehension of their function, it is fundamental to determine their tissue or cell specificity and to identify their subcellular localization. In fact, the activity of lncRNAs may vary according to cell and tissue specificity and subcellular compartmentalization. Myofibers are the smallest complete contractile system of skeletal muscle influencing its contraction velocity and metabolism. How lncRNAs are expressed in different myofibers, participate in metabolism regulation and muscle atrophy or how they are compartmentalized within a single myofiber is still unknown. We compiled a comprehensive catalog of lncRNAs expressed in skeletal muscle, associating the fiber-type specificity and subcellular location to each of them, and demonstrating that many lncRNAs can be involved in the biological processes de-regulated during muscle atrophy. We demonstrated that the lncRNA Pvt1, activated early during muscle atrophy, impacts mitochondrial respiration and morphology and affects mito/autophagy, apoptosis and myofiber size in vivo. This work corroborates the importance of lncRNAs in the regulation of metabolism and neuromuscular pathologies and offers a valuable resource to study the metabolism in single cells characterized by pronounced plasticity

Facing the future : scanning, synthesizing and sense-making in horizon scanning

Erworben im Rahmen der Schweizer Nationallizenen (http://www.nationallizenz.ch)In this paper, we discuss key issues in harnessing horizon scanning to shape systemic policies, particularly in the light of the foresight exercise ‘Facing the future: Time for the EU to meet global challenges’ which was carried out for the Bureau of European Policy Advisors. This exercise illustrates how horizon scanning can enable collective sense-making processes which assist in the identification of emerging signals and policy issues; the synthesis of such issues into encompassing clusters; and the interpretation of resulting clusters as an important step towards the coordinated development of joint policy measures. In order to achieve such objectives, horizon scanning can benefit from methods of multi-criteria decision-making and network analysis for prioritizing, clustering and combining issues. Furthermore, these methods provide support for traceability, which in turn contributes to the enhanced transparency and legitimacy of foresight

Eurashe - Conferência do 10º Aniversário "Pan Metro Ariston"

Foi nos passados dias 26 e 27 de Maio, em Chania (Creta, Grécia), no âmbito da 10ª Conferência da Eurashe (European Association for Higher Education – uma associação europeia de instituições de ensino superior não universitário), que tive o prazer de, pela primeira vez, ouvir Sócrates Kaplanis, uma figura sui generis, de quem tinha já ouvido falar por diversas vezes, conhecida pela sua saudável irreverência e perturbante personalidade. Professor no Technological Educational Institute de Patras (Grécia), e membro fundador da Eurashe, Sócrates tem sido uma presença constante nas conferências anuais desta Associação e um elemento indispensável no reavivamento dos ensinamentos clássicos (ao mesmo tempo tão contemporâneos), não fosse ele um verdadeiro grego, até mesmo de semblante. Assim, só poderia ter iniciado a sua intervenção (tarde mas não tardia) com alguns diálogos de Platão e tê-la intitulado PAN METRON ARISTON

Facing the future : time for the EU to meet global challenges

There is a clear and growing need for the capacity to anticipate change to be embedded in policy. This is critical not only to be able to respond and adapt to new situations before they occur, but also to shape the future, building upon mutual understanding and common visions to be jointly pursued. For policy responses to address all the pressing current global challenges, especially when these are seen separately from one another, is clearly a demanding task. Institutions face greater complexity and difficulty in providing solutions in due time. In particular, this is true when the policy focus extends beyond the challenges that societies face today, seeking to anticipate future challenges and transform them into opportunities. This is the rationale for the report “Facing the future: time for the EU to meet global challenges” based on a study carried out in the course of 2009 by the Joint Research Centre, Institute for Prospective Technological Studies (JRC-IPTS) for the Bureau of European Policy Advisors (BEPA) of the European Commission. The aim is to provide a comprehensive picture of the main trends ahead and possible future disruptive global challenges, and to examine how the EU could position itself to take an active role in shaping a response to them. The work described in this report brings a fresh perspective, by linking widely accepted quantified trends towards 2025 and beyond with experts’ and policy makers’ opinions on the likely consequences of these trends and wild cards

Facing the Future: Time for the EU to meet Global Challenges

What will the world look like in 2025? What are the possible future disruptive global challenges? And how can the EU position itself to take an active role in shaping a response to them? This publication offers possible answers to these questions through the identification of three main challenges and potential responses to these, and concludes that the main policy issues to be considered at EU level are: policy alignment towards sustainability; social diversity and the use of ICT for citizen empowerment; and the need to embed capabilities for anticipating future challenges to enable these to become new opportunities. The methodology applied combines widely accepted quantified trends by 2025 and beyond with the opinions of experts and policy makers on the likely consequences of these trends and wild cards. A multi-criteria quantitative analysis (Robust Portfolio Modelling) was used as a novel element to prioritise issues as a basis for discussion with selected experts and policy makers. This work has been undertaken in close cooperation with the Bureau of European Policy Advisors of the European Commission.JRC.DDG.J.3-Knowledge for Growt