Behaviour of traffic on a link with traffic light boundaries

This paper considers a single link with traffic light boundary conditions at both ends, and investigates the traffic evolution over time with various signal and system configurations. A hydrodynamic model and a modified stochastic domain wall theory are proposed to describe the local density variation. The Nagel-Schreckenberg model (NaSch), an agent based stochastic model, is used as a benchmark. The hydrodynamic model provides good approximations over short time scales. The domain wall model is found to reproduce the time evolution of local densities, in good agreement with the NaSch simulations for both short and long time scales. A systematic investigation of the impact of network parameters, including system sizes, cycle lengths, phase splits and signal offsets, on traffic flows suggests that the stationary flow is dominated by the boundary with the smaller split. Nevertheless, the signal offset plays an important role in determining the flow. Analytical expressions of the flow in relation to those parameters are obtained for the deterministic domain wall model and match the deterministic NaSch simulations. The analytic results agree qualitatively with the general stochastic models. When the cycle is sufficiently short, the stationary state is governed by effective inflow and outflow rates, and the density profile is approximately linear and independent of time

Early History of the Department of Chemisty of the Ohio State University

Author Institution: Department of Chemistry, Ohio State UniversitySidney Norton, appointed in 1873, was the first professor of chemistry at Ohio State, and for 20 years the only faculty member of the department. In these early years the annual student enrollment in chemistry was often less than 50. The growth of the department began in 1893 with the appointment of William McPherson as an assistant professor. By 1900, two more faculty members were added, and at the end of the first half century of its existence, there were 9 senior faculty members aided by a junior staff of about 40 assistants and graduate assistants. The undergraduate enrollment then totalled about 2,000 and the number of graduate students about 100

MF976

Homer K. Caley, Grass tetany, Kansas State University, March 1991

Tumor-associated Endo180 requires stromal-derived LOX to promote metastatic prostate cancer cell migration on human ECM surfaces

The diverse composition and structure of extracellular matrix (ECM) interfaces encountered by tumor cells at secondary tissue sites can influence metastatic progression. Extensive in vitro and in vivo data has confirmed that metastasizing tumor cells can adopt different migratory modes in response to their microenvironment. Here we present a model that uses human stromal cell-derived matrices to demonstrate that plasticity in tumor cell movement is controlled by the tumor-associated collagen receptor Endo180 (CD280, CLEC13E, KIAA0709, MRC2, TEM9, uPARAP) and the crosslinking of collagen fibers by stromal-derived lysyl oxidase (LOX). Human osteoblast-derived and fibroblast-derived ECM supported a rounded ‘amoeboid-like’ mode of cell migration and enhanced Endo180 expression in three prostate cancer cell lines (PC3, VCaP, DU145). Genetic silencing of Endo180 reverted PC3 cells from their rounded mode of migration towards a bipolar ‘mesenchymal-like’ mode of migration and blocked their translocation on human fibroblast-derived and osteoblast-derived matrices. The concomitant decrease in PC3 cell migration and increase in Endo180 expression induced by stromal LOX inhibition indicates that the Endo180-dependent rounded mode of prostate cancer cell migration requires ECM crosslinking. In conclusion, this study introduces a realistic in vitro model for the study of metastatic prostate cancer cell plasticity and pinpoints the cooperation between tumor-associated Endo180 and the stiff microenvironment imposed by stromal-derived LOX as a potential target for limiting metastatic progression in prostate cancer