Development and evaluation of a 3D printing protocol to produce zolpidem-containing printlets, as compounding preparation, by the pressurized-assisted microsyringes technique

Insomnia is a chronic disorder with a mean prevalence ranged from 6% to 15% worldwide. The usual pharmacologic treatment for insomnia has been benzodiazepines and barbiturates. More recently, z-drugs were introduced in the therapeutic arsenal to maximize benefits and minimize treatment damage. Zolpidem tartrate, whose primary indication is for sleep initiation problems, is conventionally used at a recommended dose of 5 mg for women as well as elderly patients (< 65 years-old) and 10 mg for non-elderly men. However, it was demonstrated that the dose of zolpidem should be adjusted according to the gender, age, condition of the patient and the presence of polypharmacy to decrease the occurrence of adverse events. Faced with the therapeutic limitations inherent to marketed products, magistral preparations offer medical and legal alternatives to mass treatment. The use of a semi-automatic technique, with standardized protocol, such as 3D printing should be advantageously implemented as an alternative to standard compounding procedures. In this work, the pressure-assisted microsyringes method was selected as it allows the tridimensional printing, and so the customization of the dose, by easily extruding a viscous semi-liquid material, called "slurry", through a syringe at room temperature. It has been demonstrated that this methodology allows obtaining printlets that responded to the zolpidem-containing tablets monograph of the US pharmacopoeia Edition 42. The compounding preparations proposed in this work therefore have the same criteria of requirements as a commercial form

Constraining instantaneous fluxes and integrated compositions of fluvially discharged organic matter

Author Posting. © American Geophysical Union, 2018. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Freymond, C. V., Lupker, M., Peterse, F., Haghipour, N., Wacker, L., Filip, F., et al. (2018). Constraining instantaneous fluxes and integrated compositions of fluvially discharged organic matter. Geochemistry, Geophysics, Geosystems, 19, 2453 2462. doi: 10.1029/2018GC007539.Fluvial export of organic carbon (OC) and burial in ocean sediments comprises an important carbon sink, but fluxes remain poorly constrained, particularly for specific organic components. Here OC and lipid biomarker contents and isotopic characteristics of suspended matter determined in depth profiles across an active channel close to the terminus of the Danube River are used to constrain instantaneous OC and biomarker fluxes and integrated compositions during high to moderate discharges. During high (moderate) discharge, the total Danube exports 8 (7) kg/s OC, 7 (3) g/s higher plant‐derived long‐chain fatty acids (LCFA), 34 (21) g/s short‐chain fatty acids (SCFA), and 0.5 (0.2) g/s soil bacterial membrane lipids (brGDGTs). Integrated stable carbon isotopic compositions were TOC: −28.0 (−27.6)‰, LCFA: −33.5 (−32.8)‰ and Δ14C TOC: −129 (−38)‰, LCFA: −134 (−143)‰, respectively. Such estimates will aid in establishing quantitative links between production, export, and burial of OC from the terrestrial biosphere.This project was funded by the Swiss National Science Foundation SNF. Grant Number: 200021_140850. F.P. acknowledges funding from NWO‐VENI grant 863.13.016. We thank the sampling crews from both field campaigns (Björn Buggle, James Saenz, Alissa Zuijdgeest, Marilu Tavagna, Stefan Eugen Filip, Silvia Lavinia Filip, Mihai, Clayton Magill, Thomas Blattmann, and Michael Albani), Daniel Montluçon for lab support and Hannah Gies for PCGC work. Figures, tables, and equations can be found in supporting information

A microwave discharge source operating at pressures of several atmospheres

The design of a microwave source in which a discharge is initiated by an electromagnetic surface wave at 2.45 GHz is described. A stable discharge was supported at a gas pressure p (0) exceeding the atmospheric pressure in He, N-2, and in H-2-Ar, H-2-He, and O-2-He mixtures in a 2-mm inner diameter quartz tube with a 0.15-mm diameter nozzle at a 50- to 115-W microwave power. A degree of dissociation of up to 80% was reached for pure H-2 at p (0) = 6 Torr and a 6% mixture of H-2 and He at p (0) = 50 Torr. When p (0) increases to 19 Torr for H-2 and to 300 Torr for the mixture, the hydrogen-atom beam intensity, in spite of a decrease in the degree of dissociation, increases due to narrowing of the beam particle velocity distribution

Myxome cardiaque de l'enfant (localisation ventriculaire gauche et récidive ventriculaire droite)

PARIS7-Xavier Bichat (751182101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Innovations en e-santé (accompagnement de patients atteints de maladies chroniques)

MONTPELLIER-BU Pharmacie (341722105) / SudocSudocFranceF

Anthropologie culturelle et politique de la yole ronde à la Martinique (enjeux identitaires et atouts pour une politique de Région. Perspectives comparatives)

Notre étude envisage le développement de la yole ronde, sport traditionnel pratiqué à la Martinique, département français d Amérique. Alors que quasiment toutes les disciplines sportives actuelles pratiquées à la Martinique ont été importées d Europe, preuve d un conditionnement social et culturel, la voile à la Martinique est restée sous sa forme traditionnelle, et se pratique avec des embarcations locales comme la yole ronde.Au cours de son histoire, la yole ronde a connu de profondes mutations qui ont irrémédiablement transformé les formes de pratique et remis en question son caractère traditionnel. Ce sport pieds-nus connaît depuis une dizaine d années un regain d intérêt auprès de la population martiniquaise qui la considère comme LA pratique ayant résisté à la longue période d acculturation occidentale. Mais cette vision de l activité n est-elle pas un simple construit social, permettant aux Martiniquais de s identifier à une pratique signifiant le savoir, l habileté ou la richesse culturelle d un peuple en quête d identité ? N est-elle pas instrumentalisée par les élites politiques locales afin d en tirer toute sorte de profits, économiques, politiques ou encore culturels ? Par des informations recueillies au travers de sources documentaires mais surtout par les témoignages d acteurs qui vivent et pratiquent la yole au quotidien, nous montrons que le processus d innovation culturelle à l œuvre dans la yole, tout en se complexifiant, a produit, étape après étape, une configuration systémique de l expression identitaire et de l intégration sociale à laquelle sont liés des enjeux socio-économiques et politiques.L analyse détaillée de cet objet anthropologique singulier gagne à être replacée dans le cadre d une approche comparée qui nous a permis d inventorier tout un univers de pratiques et de modèles qui partagent entre eux sinon une insularité (Martinique, Guadeloupe, Polynésie française), à tout le moins une situation périphérique (Bassin d Arcachon et Pays basque) concomitante à une certaine maritimité et une commune remise au goût du jour des anciens gréements ou engins de navigation, identifiée par un processus de sportivisation .Through this document we intend to study the expansion of yole sailing , a traditional sport practised in Martinique , a French overseas department. Whereas practically all the current sports done in Martinique have been imported from Europe, which reveals social and cultural conditioning, sailing has still maintained its traditional practices, using local skiffs such as the yole ronde .All along its history, the yole ronde has undergone profound changes that have irreparably altered the conventional practices and called its traditionalism into question. For ten years or so this barefoot sport has aroused a renewed interest among the natives of Martinique as they regard it as THE practice that has stood up to the long period of Occidental acculturation. But isn t that view of yole sailing a mere social trend built up to lead the people of Martinique to identify with a practice bringing out the knowledge, the skill and the cultural richness of a people in search for identity ? Isn t it an ideological tool used by the main local politicians in order to derive all sorts of economic, political or cultural benefits ?Thanks to information collected through documents, but mainly thanks to the testimonies of the actors daily involved in this practice, we demonstrate that the cultural innovation process implemented in yole sailing, while getting more complex, has produced, step by step, a systemic configuration of the desire for identity and the social integration connected to socioeconomic and political stakes.It will be better for the detailed analysis of this singular anthropological subject to be put back within the context of a comparative approach which has enabled us to make an inventory of a world of practices and of models that share, if not the fact of being islanders (Martinique,Guadeloupe, French Polynesia), then at least a peripheral situation (Bassin d Arcachon and the Basque country), concomitant to a certain maritimity and a common bringing up to date of the old sailing ships or tools, identified by a process of sports practising .BORDEAUX2-Bib. électronique (335229905) / SudocSudocFranceF