Un «Miroir des Princes»: le «Basilikos» libanien de 348.

Sin resume

Clinical and genomic analysis of a randomised phase II study evaluating anastrozole and fulvestrant in postmenopausal patients treated for large operable or locally-advanced hormone-receptor-positive breast cancer

Background: The aim of this study was to assess the efficacy of neoadjuvant anastrozole and fulvestrant treatment of large operable or locally-advanced hormone- receptor-positive breast cancer not eligible for initial breast-conserving surgery, and to identify genomic changes occurring after treatment. Methods: 120 post-menopausal patients were randomised to receive 1 mg anastrozole (61 patients) or 500 mg fulvestrant (59 patients) for 6 months. Genomic DNA copy number profiles were generated for a subgroup of 20 patients before and after treatment. Results: 108 patients were evaluable for efficacy and 118 for toxicity. The objective response rate determined by clinical palpation was 58.9% (95% CI 45.0-71.9) in the anastrozole arm and 53.8% (95% CI 39.5-67.8) in the fulvestrant arm. The breast- conserving surgery rate was 58.9% (95% CI 45.0-71.9) in the anastrozole arm and 50.0% (95% CI 35.8-64.2) in the fulvestrant arm. Pathological responses >50% occurred in 24 patients (42.9%) in the anastrozole arm and 13 (25.0%) in the fulvestrant arm. The Ki-67 score fell after treatment but there was no significant difference between the reduction in the two arms (anastrozole 16.7% [95%CI 13.3-21.0] before, 3.2% [95%CI 1.9-5.5] after, n=43; fulvestrant 17.1% [95%CI 13.1-22.5] before, 3.2% [95%CI 1.8-5.7] after, n=38) or between the reduction in Ki-67 in clinical responders and non- responders. Genomic analysis appeared to show a reduction of clonal diversity following treatment with selection of some clones with simpler copy number profiles. Conclusion: Both anastrozole and fulvestrant were effective and well-tolerated, enabling breast-conserving surgery in over 50% of patients. Clonal changes consistent with clonal selection by the treatment were seen in a subgroup of patients

Nathalie Bélanger De la psychologie scolaire à la politique de l'enfance inadaptée

Avec De la psychologie scolaire à la politique de l'enfance inadaptée, Nathalie Bélanger nous découvre un épisode de l'histoire peu étudiée des politiques et des mesures en faveur de l'enfance inadaptée, dite plus souvent aujourd'hui handicapée. Plus exactement, il nous en fait parcourir un détour, puisque son titre ne suggère pas une démarche chronologique mais plutôt un itinéraire qui, partant de l'observation de la genèse et du développement de la psychologie scolaire en France, nou..

The supply and movement of Denarii in Roman Britain

Hoards of denarii are common in Britain and the number which have been recorded in detail means that it is now possible to suggest reasonably accurately what a ‘normal’ hoard of a particular date should look like. That being the case, we can then look for variation around that norm and both investigate and speculate what that variation means. A methodology is developed which suggests periods of faster and less rapid coin circulation which has implications for consideration of monetisation. The model also enables us to view where denarii entered circulation; unsurprisingly the army looms large in this picture. The methodology is directly transferable to other provinces and other periods where there are longlived, relatively stable monetary systems

Grain and plant protein types fed to weaned piglets influence the apparent digestibility of carbohydrates and crude protein when measured at the terminal ileum

Diets based on cooked white rice fed to weaned piglets have a higher apparent ileal digestibility of starch than diets based on wheat (Pluske et al., 2007). The diets based on cooked white rice have used predominately animal sources of protein, however in Europe these are banned or excluded by retailer's specifications (except for milk proteins), and plant proteins are widely used instead. This study examined the interactive effects of cereal types and plant protein types on the apparent ileal digestibility of protein and carbohydrates to test the proposition that suitable sources of plant protein could ensure high digestibility coefficients in the small intestine

La machine optique de l’architecture : desseins et dessins de Jean-Paul Jungmann

Configuré par la pensée de Mai 68 et ses rêves d’utopie, Jean-Paul Jungmann invente une architecture de papier au centre de laquelle le dessin, poétique, littéraire et fantasmagorique, recompose pratiques et formes urbaines.With Mai 1968 events in mind and dreams, Jean-Paul Jungmann fancies an architecture of paper, inside which poetic, literary and phantasmagoric drawing, rebuilds urban shapes and practices.Unter dem Einfluss der Pariser 68er-Bewegung und deren gesellschaftlicher Utopien entwickelt Jean-Paul Jungmann eine papierbasierte Architektur, in deren Zentrum die poetische, literarische und phantastische Zeichnung steht, welche urbane Formen und Praktiken neu zusammenfügt

Differentiating neural systems mediating the acquisition vs. expression of goal-directed and habitual behavioral control

Considerable behavioral data indicate that operant actions can become habitual, as demonstrated by insensitivity to changes in the action–outcome contingency and in subjective outcome values. Notably, although several studies have investigated the neural substrates of habits, none has clearly differentiated the areas of the human brain that support habit formation from those that implement habitual control. We scanned participants with functional magnetic resonance imaging as they learned and performed an operant task in which the conditional structure of the environment encouraged either goal-directed encoding of the consequences of actions, or a habit-like mapping of actions to antecedent cues. Participants were also scanned during a subsequent assessment of insensitivity to outcome devaluation. We identified dissociable roles of the cerebellum and ventral striatum, across learning and test performance, in behavioral insensitivity to outcome devaluation. We also showed that the inferior parietal lobule (an area previously implicated in several aspects of goal-directed action selection, including the attribution of intent and awareness of agency) predicted sensitivity to outcome devaluation. Finally, we revealed a potential functional homology between the human subgenual cortex and rodent infralimbic cortex in the implementation of habitual control. In summary, our findings suggested a broad systems division, at the cortical and subcortical levels, between brain areas mediating the encoding and expression of action–outcome and stimulus–response associations

Experimental and modeling investigation of the laminar flame speeds for ammonia with various oxygen and diluent mixtures

The study utilizes two spherical bombs to explore the Laminar Flame Speed (LFS) and Markstein length of oxygen-enriched ammonia flames and ammonia combined with different oxidizers (N 2 with 21% and 30% O 2 and He with 21% O 2 ). The experiments cover a range of initial conditions, exploring temperatures from 309 K to 423 K and an equivalence ratio spanning from 0.8 to 1.3, all at an initial pressure of 1 bar. At the same time, three established literature mechanisms (Stagni, Shrestha, and Zhang) are used to simulate the data and perform kinetic analysis. A detailed analysis focuses on how the radius of the domain affects LFS, highlighting the importance of a larger domain, in contrast with findings from previous literature. The findings highlighted that, although LFS increased (as expected) with the increase in the initial temperature, the Markstein length remains largely unaffected in oxygen-enriched ammonia flames. This was also calculated using Bechtold and Matalon 's approach, and the results were in a good agreement with the experimental values. The study determines alpha exponents across an equivalence ratio range of 0.8 to 1.3, and also found that the inert gas has varying effects on both LFS and Markstein length. Buoyancy effects were noticeable in the ammonia/air experiments, particularly at lower temperatures, challenging existing literature heavily focused on ammonia blends at temperatures below 400 K, potentially contributing to data discrepancies observed in prior studies