Rifugiati o libertà? Le responsabilità dell’Europa nella crisi dei rifugiati siriani in Turchia.

Le responsabilità dell'Europa nella crisi dei rifugiati siriani in Turchi

«Secondo Matteo». Rimandi biblici nel “Campo del vasaio” di Andrea Camilleri

Quali sono i rapporti complessi e interessanti che Andrea Camilleri intesse con il registro del sacro nel romanzo “Il campo del vasaio?” A sostegno della tesi che parecchi scrittori «del Novecento continuino ad 'essere parlati' dal linguaggio del sacro» radicato «alla base dell'apprendimento linguistico individuale», “Il Campo del vasaio” si rivela così una riscrittura in chiave sordida e criminale di una celeberrima pagina del “Vangelo”, riscrittura cifrata che il commissario Montalbano decodificherà con perseveranza e acume, forte della sua attenta lettura dei testi sacri

La teoria politica nel pensiero libertino intorno a F.A. Cappelletti, "Science, Religion et Politique dans l’utopie libertine", Parigi, 2013

Il libro presenta un’analisi completa ed approfondita delle opere degli scrittori del libertinismo, dai più celebri come Cyrano de Bergerac ai meno noti. Il risultato cui perviene Cappelletti è che la produzione letteraria del libertinismo, nonostante racconti di storie di viaggi fantastici, contiene i semi del pensiero rivoluzionario che si svilupperà compiutamente nel XVIII secolo, riconducibili ad elementi di teoria politica moderna

Recensione a: L. Zavatta, «Nietzsche nello sviluppo della filosofia giuridica e morale», Progedit, Bari, 2014, pp. 220.

Il libro approfondisce il pensiero di Nietzsche sui temi del diritto e dello Stato, ponendo al centro dell’opera un’attenta analisi del pensiero del filosofo di Röcken seppur allargando l’indagine alle tematiche sviluppatesi nel pensiero filosofico giuridico di molti autori della modernità. Viene posto in risalto il ruolo di fondamentale importanza rivestito dal diritto nelle relazioni intersoggettive; diritto che si connota come l’arte o la tecnica più efficace di cui l’uomo disponga per regolare gli aspetti della vita sociale, altrimenti caotica ed orientata verso la distruzione

Monetary Policy and the Relative Price of Durable Goods

In a VAR model of the US, the response of the relative price of durables to a monetary contraction is either flat or mildly positive. It significantly falls only if narrowly defined as the ratio between new house and nondurables prices. These findings survive three identification strategies and across subsamples. Then, they are rationalized via the estimation of a two-sector New-Keynesian model. Here, the degree of overall durables price stickiness is not dramatically lower than that of nondurables. Such macroeconometric results are close to recent microeconometric evidence. Moreover, they suggest that monetary policy is not very distortive of sectoral allocations

The girl mother: incest and maternity

Trata-se de um estudo de caso de uma adolescente de quinze anos, vítima de incesto perpetrado pelo padrasto, que teve como consequência sua gravidez e o nascimento de uma criança. O principal objetivo é discutir a reorganização familiar da adolescente, seu silêncio e o de sua família em relação ao abuso sexual. O contexto de pesquisa foi o Centro de Referência em Assistência Social (CRAS) de uma cidade de periferia. O método utilizado foi a observação participante. A organização das informações possibilitou construir Zonas de Sentido que se constituem em indicadores de vulnerabilidade: sua relação com a violência sofrida; sua relação com a família; sua relação com a filha e sua relação com a escola. Nesse caso, o silêncio, o isolamento e a migração para outra cidade foram opções de proteção. O estudo da gravidez nesta circunstância requer uma compreensão particularizada em relação ao estudo de adolescentes grávidas em geral.This article presents a case study of a fifteen-year-old teenager girl, a victim of incest perpetrated by her stepfather, who became pregnant and gave birth to a child. Our main purpose is to discuss the teenager´s familiar reorganization, the girl's and her family´s silence in relation to the sexual abuse. The Center of Social Assistance (CRAS) in a low-income suburb was the environment of research. The method was the participant observation. From the data obtained we identified four indicators of the adolescent´s vulnerability: her relation to the violence suffered, her relationship with her family, her relationship with her daughter, and her relationship with school. In this case, silence, isolation and the migration to another city were options for the family's self protection. The study of pregnancy in this circunstance requires a particular understanding on pregnant adolescents in general

Cell delivery of Met docking site peptides inhibit angiogenesis and vascular tumor growth.

Angiogenesis is a very complex biological process that drives the formation of new blood vessels starting from pre-existing one. In adulthood, it occurs both in physiological and pathological processes. Pathological angiogenesis is involved in several diseases, including cancer. In the last decade, the concept of anti-angiogenic therapy has been developed as a strategy to treat cancer inducing the inhibition of new vessels that provide sustenance to the tumor. Recently, Met receptor and its ligand HGF (Hepatocyte Growth Factor) has been proposed as target for the anti-angiogenic therapy. HGF and its receptor Met are responsible for a wide variety of cellular responses, both physiologically during embryo development and tissue homeostasis, and pathologically, particularly during tumor growth and dissemination. In cancer, Met can act as an oncogene on tumor cells, as well as a pro-angiogenic factor activating endothelial cells and inducing new vessel formation. Molecules interfering with Met activity could be valuable agents for anti-cancer treatment simultaneously inhibiting oncogenesis and angiogenesis. The aim of this study has been the identification of peptides able to interfere with HGF-induced angiogenesis. We synthesized three different peptides containing the Met docking site fused to the internalization sequences of Antennapedia homeodomain or of Tat transactivation domain which were used to deliver peptides into living cells. In vitro we treated human endothelial cells with peptides and we quantified proliferation. We then evaluated the ability of peptides to interfere with HGF-induced migration, invasion and morphogenesis of endothelial cells. By western blotting analysis we investigated whether these peptides affect Met activation and downstream signalling. In vivo we performed matrigel sponge assay and Kaposi\u2019s sarcoma xenograft to test the peptides efficacy on angiogenesis and tumor growth. We observed that in endothelial cells internalized peptides inhibited ligand-dependent cell proliferation, motility, invasiveness and morphogenesis in vitro, to an even greater extent and with much less toxicity than the Met inhibitor PHA-665752, which correlated with interference of HGF-dependent downstream signalling, as shown by reduction in ERK1/2 activation (Cantelmo et al.). In vivo, the peptides inhibited HGF-induced angiogenesis in the matrigel sponge assay and impaired xenograft tumor growth and vascularization in Kaposi\u2019s sarcoma (Cantelmo et al.). These data show that interference with the Met receptor intracellular sequence impairs HGF-induced angiogenesis, suggesting the use of antidocking site compounds as a therapeutic strategy to counteract angiogenesis in cancer as well as in other diseases

Including the influence of waves in the overall slope stability analysis of rubble mound breakwaters

An offshore breakwater is designed for the construction of a LNG-terminal. For the slope stability analysis of the rubble mound breakwater the existing and the extreme wave climate are considered. Pore water pressure variations exist in the breakwater and its permeable foundation. A wave trough combined with the moment of maximum wave run-up results in a decrease and increase of the pore water pressure, respectively. Therefore, the wave actions have on overall effect on the slope stability of the breakwater. To include the wave actions in the slope stability analysis a simplified method is used. For the slope stability analysis, a specific piezometric line is determined. This piezometric line consists of a wave profile and the profile of wave run-up. The slope stability analysis are performed with GEO-SLOPE/W 2007. For the geotechnical design of the breakwater load cases of extreme and normal waves combined with, respectively, extreme and normal water levels are analysed. All the load cases which included the wave actions result in lower stability safety factors than the load cases with only still water levels. Therefore the wave actions are the determining load case for the geotechnical stability of the breakwater and it should be studied in detail

Sectoral Labor Mobility and Optimal Monetary Policy

How should central banks optimally aggregate sectoral inflation rates in the presence of imperfect labor mobility across sectors? We study this issue in a two-sector New-Keynesian model and show that a lower degree of sectoral labor mobility, ceteris paribus, increases the optimal weight on inflation in a sector that would otherwise receive a lower weight. We analytically and numerically find that, with limited labor mobility, adjustment to asymmetric shocks cannot fully occur through the reallocation of labor, thus putting more pressure on wages, causing inefficient movements in relative prices, and creating scope for central banks intervention. These findings challenge standard central banks practice of computing sectoral inflation weights based solely on sector size, and unveil a significant role for the degree of sectoral labor mobility to play in the optimal computation. In an extended estimated model of the U.S. economy, featuring customary frictions and shocks, the estimated inflation weights imply a decrease in welfare up to 10 percent relative to the case of optimal weights

A low dimensional model for bike sharing demand forecasting

Big, transport-related datasets are nowadays publicly available, which makes data-driven mobility analysis possible. Trips with their origins, destinations and travel times are collected in publicly available big databases, which allows for a deeper and richer understanding of mobility patterns. This paper proposes a low dimensional approach to combine these data sources with weather data in order to forecast the daily demand for Bike Sharing Systems (BSS). The core of this approach lies in the proposed clustering technique, which reduces the dimension of the problem and, differently from other machine learning techniques, requires limited assumptions on the model or its parameters. The proposed clustering technique synthesizes mobility data quantitatively (number of trips) and spatially (mean trip origin and destination). This allows identifying recursive mobility patterns that - when combined with weather data - provide accurate predictions of the demand. The method is tested with real-world data from New York City. We synthesize more than four million trips into vectors of movement, which are then combined with weather data to forecast the daily demand at a city-level. Results show that, already with a one-parameters model, the proposed approach provides accurate predictions.Comment: 2019 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other work