250 research outputs found

    Desvictimizar : recuperando memoria de dos generaciones en el rescate de fortalezas y resiliencias resistentes durante dictadura militar en Chile

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    En primer lugar, en esta investigación me posiciono como investigadora comprometida y desde una propuesta epistemológica de un conocimiento situado (Haraway, 1995), que además de serlo está “enraizado, afectado y cotidiano porque genera un compromiso que se traduce en acción concreta que necesita entregar para poder existir" (León 2010, p. 6). Se trata de recordar, conocer y comprender en forma reflexiva, otros diseños de vida y de país que quedaron truncos, pero no aniquilados. Es así como el objetivo general fue investigar y analizar mediante el tejido de la memoria y desde una perspectiva desvictimizadora, experiencias y vivencias de un grupo de mujeres durante su permanencia en la cárcel y/o exilio; así como la de nuestras/os hijos e hijas nacidos/as dentro y fuera de Chile durante la dictadura militar, 11 de septiembre de 1973 a marzo de 1990. Lo relevante de este estudio fue rescatar fortalezas y recursos personales que utilizamos dos generaciones en nuestras vidas cotidianas. Investigación que dio cuenta y cuestionó, desde el imaginario personal, social y colectivo, implicaciones y presupuestos establecidos sobre el concepto de víctima de violencia política. Fue un trabajo de investigación tejido con las voces del pasado en el presente y con proyección al futuro. De ahí radica la importancia de rescatar las vivencias de las luchadoras sociales de esos tiempos y ponerlos en relación con lo que hacemos hoy día. También se trata de dar cuenta en qué están hoy nuestras/os hijas/os.Fil: Benavides Andrades, María Angélica. Universidad Autónoma de BarcelonaFil: Cantera E., Leonor M.. Universidad Autónoma de BarcelonaFil: Alvarado, Patricia. Universidad Autónoma de Barcelon

    MA

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    thesisIn 1894, John Hyrum Koyle began digging the Dream Mine, on a mountaintop in central Utah. Koyle, a Mormon bishop, had been shown where to dig, he said, by Moroni, the same heavenly messenger who had led Mormon founder Joseph Smith to unearth the golden plates. Moroni visited Koyle in a dream and showed him nine enormous caverns below the mountain, containing countless piles of gold. Moroni told Koyle that the gold would remain hidden in the caves until an unspecified time preceding the Second Coming of Jesus Christ. At that moment of chaos, Koyle and his followers would unearth the gold and it would support the financially-troubled Mormon Church through the Last Days. This thesis investigates the nature of belief in the Dream Mine, which remains fervent more than 100 years later. Although their dreams are perpetually deferred, believers tap into a rich vein of folklore that runs through Mormon cosmology. Over the past thirty years, the Dream Mine has enabled believers to maintain a psychic link to a magical past, as their church adapts to a changing, modern world. This thesis will consider how Dream Mine belief has evolved in a changing economic, political, and religious landscape, and demonstrate that the faithful find sustenance in the Mormon past while simultaneously embracing modern worldviews that extend beyond mainstream Mormonism

    The Glial Regenerative Response to Central Nervous System Injury Is Enabled by Pros-Notch and Pros-NFκB Feedback

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    Organisms are structurally robust, as cells accommodate changes preserving structural integrity and function. The molecular mechanisms underlying structural robustness and plasticity are poorly understood, but can be investigated by probing how cells respond to injury. Injury to the CNS induces proliferation of enwrapping glia, leading to axonal re-enwrapment and partial functional recovery. This glial regenerative response is found across species, and may reflect a common underlying genetic mechanism. Here, we show that injury to the Drosophila larval CNS induces glial proliferation, and we uncover a gene network controlling this response. It consists of the mutual maintenance between the cell cycle inhibitor Prospero (Pros) and the cell cycle activators Notch and NFκB. Together they maintain glia in the brink of dividing, they enable glial proliferation following injury, and subsequently they exert negative feedback on cell division restoring cell cycle arrest. Pros also promotes glial differentiation, resolving vacuolization, enabling debris clearance and axonal enwrapment. Disruption of this gene network prevents repair and induces tumourigenesis. Using wound area measurements across genotypes and time-lapse recordings we show that when glial proliferation and glial differentiation are abolished, both the size of the glial wound and neuropile vacuolization increase. When glial proliferation and differentiation are enabled, glial wound size decreases and injury-induced apoptosis and vacuolization are prevented. The uncovered gene network promotes regeneration of the glial lesion and neuropile repair. In the unharmed animal, it is most likely a homeostatic mechanism for structural robustness. This gene network may be of relevance to mammalian glia to promote repair upon CNS injury or disease

    The Effect of a Physical Activity Program on the Total Number of Primary Care Visits in Inactive Patients: A 15-Month Randomized Controlled Trial

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    Abstract Background: Effective promotion of exercise could result in substantial savings in healthcare cost expenses in terms of direct medical costs, such as the number of medical appointments. However, this is hampered by our limited knowledge of how to achieve sustained increases in physical activity. Objectives: To assess the effectiveness of a Primary Health Care (PHC) based physical activity program in reducing the total number of visits to the healthcare center among inactive patients, over a 15-month period. Research Design: Randomized controlled trial. Subjects: Three hundred and sixty-two (n = 362) inactive patients suffering from at least one chronic condition were included. One hundred and eighty-three patients (n = 183; mean (SD); 68.3 (8.8) years; 118 women) were randomly allocated to the physical activity program (IG). One hundred and seventy-nine patients (n = 179; 67.2 (9.1) years; 106 women) were allocated to the control group (CG). The IG went through a three-month standardized physical activity program led by physical activity specialists and linked to community resources. Measures: The total number of medical appointments to the PHC, during twelve months before and after the program, was registered. Self-reported health status (SF-12 version 2) was assessed at baseline (month 0), at the end of the intervention (month 3), and at 12 months follow-up after the end of the intervention (month 15). Results: The IG had a significantly reduced number of visits during the 12 months after the intervention: 14.8 (8.5). The CG remained about the same: 18.2 (11.1) (P = .002). Conclusions: Our findings indicate that a 3-month physical activity program linked to community resources is a shortduration, effective and sustainable intervention in inactive patients to decrease rates of PHC visits. Trial Registration: ClinicalTrials.gov NCT0071483

    Modern approach to the treatment of dry eye, a complex multifactorial disease: a P.I.C.A.S.S.O. board review

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    Dry eye disease (DED) is a growing public health concern affecting quality of life and visual function, with a significant socio-economic impact. It is characterised by the loss of homoeostasis, resulting in tear film instability, hyperosmolarity and inflammation of the ocular surface. If the innate immune response is unable to cope with internal bodily or environmental adverse conditions, the persistent, self-maintaining vicious circle of inflammation leads to the chronic form of the disease. Treatment of DED should be aimed at the restoration of the homoeostasis of the ocular surface system. A proper diagnostic approach is fundamental to define the relevance and importance of each of the DED main pathogenic factors, namely tear film instability, epithelial damage and inflammation. Consideration also needs to be given concerning two other pathogenic elements: lid margin changes and nerve damage. All the factors that maintain the vicious circle of DED in the patient's clinical presentation have to be considered and possibly treated simultaneously. The treatment should be long-lasting and personalised since it has to be adapted to the different clinical conditions observed along the course of the disease. Since DED treatment is frequently unable to provide fast and complete relief from symptoms, empathy with patients and willingness to explain to them the natural history of the disease are mandatory to improve patients' compliance. Furthermore, patients should be instructed about the possible need to increase the frequency and/or change the type of treatment according to the fluctuation of symptoms, following a preplanned rescue regimen

    Analysis of gender equality competence present in cultural positions

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    Articulating the gender dimension in organizations is not easy because their members have to be trained to adopt positions that facilitate the implementation of solutions that help to combat inequalities. The aim of this article was to identify the gender equality competence present in the three types of cultural positions Castells proposed in members of a City Council in Sevilla-Spain, who wanted to implement gender mainstreaming. The participants were 27 people (16 women and 11 men). The method used was discourse analysis. The obtained results show that, while all competences were present in the project position, in the resistance position, there was none. In the legitimizers, we observed inconsistency in the discourse presented. This arouses considerations on the importance of knowing the gender equality competences in order to implement gender mainstreaming in organization

    Ammonia oxidation: Ecology, physiology, biochemistry and why they must all come together

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    Ammonia oxidation is a fundamental core process in the global biogeochemical nitrogen cycle. Oxidation of ammonia (NH3) to nitrite (NO2 −) is the first and rate-limiting step in nitrification and is carried out by distinct groups of microorganisms. Ammonia oxidation is essential for nutrient turnover in most terrestrial, aquatic and engineered ecosystems and plays a major role, both directly and indirectly, in greenhouse gas production and environmental damage. Although ammonia oxidation has been studied for over a century, this research field has been galvanised in the past decade by the surprising discoveries of novel ammonia oxidising microorganisms. This review reflects on the ammonia oxidation research to date and discusses the major gaps remaining in our knowledge of the biology of ammonia oxidation

    Perspectives and Integration in SOLAS Science

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    Why a chapter on Perspectives and Integration in SOLAS Science in this book? SOLAS science by its nature deals with interactions that occur: across a wide spectrum of time and space scales, involve gases and particles, between the ocean and the atmosphere, across many disciplines including chemistry, biology, optics, physics, mathematics, computing, socio-economics and consequently interactions between many different scientists and across scientific generations. This chapter provides a guide through the remarkable diversity of cross-cutting approaches and tools in the gigantic puzzle of the SOLAS realm. Here we overview the existing prime components of atmospheric and oceanic observing systems, with the acquisition of ocean–atmosphere observables either from in situ or from satellites, the rich hierarchy of models to test our knowledge of Earth System functioning, and the tremendous efforts accomplished over the last decade within the COST Action 735 and SOLAS Integration project frameworks to understand, as best we can, the current physical and biogeochemical state of the atmosphere and ocean commons. A few SOLAS integrative studies illustrate the full meaning of interactions, paving the way for even tighter connections between thematic fields. Ultimately, SOLAS research will also develop with an enhanced consideration of societal demand while preserving fundamental research coherency. The exchange of energy, gases and particles across the air-sea interface is controlled by a variety of biological, chemical and physical processes that operate across broad spatial and temporal scales. These processes influence the composition, biogeochemical and chemical properties of both the oceanic and atmospheric boundary layers and ultimately shape the Earth system response to climate and environmental change, as detailed in the previous four chapters. In this cross-cutting chapter we present some of the SOLAS achievements over the last decade in terms of integration, upscaling observational information from process-oriented studies and expeditionary research with key tools such as remote sensing and modelling. Here we do not pretend to encompass the entire legacy of SOLAS efforts but rather offer a selective view of some of the major integrative SOLAS studies that combined available pieces of the immense jigsaw puzzle. These include, for instance, COST efforts to build up global climatologies of SOLAS relevant parameters such as dimethyl sulphide, interconnection between volcanic ash and ecosystem response in the eastern subarctic North Pacific, optimal strategy to derive basin-scale CO2 uptake with good precision, or significant reduction of the uncertainties in sea-salt aerosol source functions. Predicting the future trajectory of Earth’s climate and habitability is the main task ahead. Some possible routes for the SOLAS scientific community to reach this overarching goal conclude the chapter

    Análisis morfogénetico preliminar de una porción de la Sierra de Pachuca, México

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    En la porción sudoriental de la sierra de Pachuca que comprende parte de los municipios de Mineral de la Reforma, Epazoyucan, Singuilucan, Villa de Tezontepec, Zempoala y Tlanalapa, en el estado de Hidalgo, se reconoce una estructura semi-elíptica de eje mayor 20 km y eje menor 13 km, interpretada como una caldera volcánica. Esta estructura posee varias geoformas volcánicas asociadas (domos, conos mongenéticos, cuellos volcánicos, derrames de lava y flujos piroclásticos). La caldera está limitada al norte por el complejo estratovolcánico riolítico de las Navajas (Pleistoceno), al este por conos monogenéticos plio-cuaternarios, al sur por el complejo dómico andesítico de Los Pitos (Mioceno-Plioceno tardío) y al oeste por flujos basálticos y piroclásticos, así como domos y cuellos volcánicos riolíticos. El análisis morfogenético de esta estructura permite establecer algunos hechos relevantes acerca de su génesis
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