Quarries, water, stone walls and groves regenerating the identity landscape of Comiso, Italy

The awareness of cultural specificity and geomorphologic and ecological singularities provides the instruments for an evolution capable of transforming the perception of the place and of recovering its memory. The design process is therefore centered in revealing character defining elements that time and indifference have blurred. A plan is then envisioned to create synergy between all these elements in order to capture the mosaic that in space and time has shaped the identity of this place to allow people to reconnect with it. The design restrains itself from a globalized language to adhere to this terrain and these traces through visual suggestions capable of weaving layers of memory to become presentPeer Reviewe

Clinical and dermoscopic features of porokeratosis of Mibelli

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Comportamiento acústico y volumétrico de las mezclas binarias de valeronitrilo + propanoato de propilo y valeronitrilo + propanoato de butilo entre 278,15 y 318,15K

Se determinaron densidades (d) y velocidades del sonido (u), para los sistemas binarios valeronitrilo + propanoato de propilo y valeronitrilo + propanoato de butilo a presión atmosférica y en un intervalo de temperaturas de 278 a 318K cada 5K. Con la información experimental, se calcularon las siguientes propiedades fisicoquímicas: VE, a, aE, Du, kS y kSE, ajustando estos resultados con la ecuación polinomial de Redlich-Kister. Las mezclas binarias presentaron valores negativos de VE, aE, Du y kSE en todo el rango de composición y temperaturas. Se realizó la predicción de la velocidad del sonido con los modelos de Nomoto, Ernst y Van Dael.Fil: Mariano, Alejandra Beatríz. Universidad Nacional del Comahue; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; ArgentinaFil: Mussari, Lelia María Ester. Universidad Nacional del Comahue; ArgentinaFil: Camacho, Alberto Gustavo. Universidad Nacional del Comahue; ArgentinaFil: Canzonieri, Salvador Humberto. Universidad Nacional del Comahue; Argentin

A range-gated pulsed ultrasonic Doppler flowmeter

http://www.worldcat.org/oclc/814450

Differential protein folding and chemical changes in lung tissues exposed to asbestos or particulates

Environmental and occupational inhalants may induce a large number of pulmonary diseases, with asbestos exposure being the most risky. The mechanisms are clearly related to chemical composition and physical and surface properties of materials. A combination of X-ray fluorescence (\u3bcXRF) and Fourier Transform InfraRed (\u3bcFTIR) microscopy was used to chemically characterize and compare asbestos bodies versus environmental particulates (anthracosis) in lung tissues from asbestos exposed and control patients. \u3bcXRF analyses revealed heterogeneously aggregated particles in the anthracotic structures, containing mainly Si, K, Al and Fe. Both asbestos and particulates alter lung iron homeostasis, with a more marked effect in asbestos exposure. \u3bcFTIR analyses revealed abundant proteins on asbestos bodies but not on anthracotic particles. Most importantly, the analyses demonstrated that the asbestos coating proteins contain high levels of \u3b2-sheet structures. The occurrence of conformational changes in the proteic component of the asbestos coating provides new insights into long-term asbestos effects

The history of small extracellular vesicles and their implication in cancer drug resistance

Small extracellular vesicles (EVs) in the last 20 years are demonstrated to possess promising properties as potential new drug delivery systems, biomarkers, and therapeutic targets. Moreover, EVs are described to be involved in the most important steps of tumor development and progression including drug resistance. The acquired or intrinsic capacity of cancer cells to resist chemotherapies is one of the greatest obstacles to overcome to improve the prognosis of many patients. EVs are involved in this mechanism by exporting the drugs outside the cells and transferring the drug efflux pumps and miRNAs in recipient cells, in turn inducing drug resistance. In this mini-review, the main mechanisms by which EVs are involved in drug resistance are described, giving a rapid and clear overview of the field to the readers

BNC2 is a putative tumor suppressor gene in high-grade serous ovarian carcinoma and impacts cell survival after oxidative stress

Rs3814113 is the single-nucleotide polymorphism (SNP) showing the strongest association with high-grade serous ovarian carcinoma (HGSOC) incidence and is located in an intergenic region about 44\u2009kb downstream of basonuclin 2 (BNC2) gene. Lifetime number of ovulations is associated with increased risk to develop HGSOC, probably because of cell damage of extrauterine M\ufcllerian epithelium by ovulation-induced oxidative stress. However, the impact of low-penetrance HGSOC risk alleles (e.g. rs3814113) on the damage induced by oxidative stress remains unclear. Therefore, the purpose of this study was to investigate whether rs3814113 genetic interval regulates BNC2 expression and whether BNC2 expression levels impact on cell survival after oxidative stress. To do this, we analyzed gene expression levels of BNC2 first in HGSOC data sets and then in an isogenic cell line that we engineered to carry a 5\u2009kb deletion around rs3814113. Finally, we silenced BNC2 and measured surviving cells after hydrogen peroxide (H2O2) treatment to simulate oxidative stress after ovulation. In this paper, we describe that BNC2 expression levels are reduced in HGSOC samples compared with control samples, and that BNC2 expression levels decrease following oxidative stress and ovulation in vitro and in vivo, respectively. Moreover, deletion of 5\u2009kb surrounding rs3814113 decreases BNC2 expression levels in an isogenic cell line, and silencing of BNC2 expression levels increases cell survival after H2O2 treatment. Altogether, our findings suggest that the intergenic region located around rs3814113 regulates BNC2 expression, which in turn affects cell survival after oxidative stress response. Indeed, HGSOC samples present lower BNC2 expression levels that probably, in the initial phases of oncogenic transformation, conferred resistance to oxidative stress and ultimately reduced the clearance of cells with oxidative-induced damages

Educación Profesional y Demanda del Sector Energético

52 Años Formando Profesionales en el Campo de la Energía y sus Aplicaciones. Facultad de Ingeniería de la Universidad Nacional del Comahue.La Universidad del Neuquén fue creada por la ley provincial N° 414, la que establecía los fundamentos para su creación y funcionamiento, dentro de ella la Facultad de Ingeniería comenzó a funcionar el 1° de abril de 1965 desde entonces es generadora de recurso humano altamente calificado que responde a las demandas del sector energético nacional e internacional