New genetic loci link adipose and insulin biology to body fat distribution.

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms

The InChildHealth Walkthrough Survey - towards a standardized characterization of classrooms for Indoor Air Quality studies in Europe

The Horizon Europe project InChildHealth aims to study indoor air quality in European schools and the effects of physical, chemical and microbiological parameters on the health of school children aged 6-13. As schools in Europe can vary considerably in terms of size, age, materials, equipment, heating, ventilation and air conditioning (HVAC), cleaning procedures etc., a questionnaire was developed for a standardized description of classrooms and schools. It includes 86 mandatory and 82 optional questions, targeting building characteristics and potential sources of exposure to particles, chemicals and microorganisms. The survey has been implemented digitally with the option of paper-based versions and future data sharing for combined data interpretation. The project foresees the possibility of revisions based on lessons learnt from the application in seven European cities. The final version can be adjusted to other microenvironments and used in future indoor air studies in Europe and elsewhere.Peer reviewe

The InChildHealth Walkthrough Survey - towards a standardized characterization of classrooms for Indoor Air Quality studies in Europe

The Horizon Europe project InChildHealth aims to study indoor air quality in European schools and the effects of physical, chemical and microbiological parameters on the health of school children aged 6-13. As schools in Europe can vary considerably in terms of size, age, materials, equipment, heating, ventilation and air conditioning (HVAC), cleaning procedures etc., a questionnaire was developed for a standardized description of classrooms and schools. It includes 86 mandatory and 82 optional questions, targeting building characteristics and potential sources of exposure to particles, chemicals and microorganisms. The survey has been implemented digitally with the option of paper-based versions and future data sharing for combined data interpretation. The project foresees the possibility of revisions based on lessons learnt from the application in seven European cities. The final version can be adjusted to other microenvironments and used in future indoor air studies in Europe and elsewhere. © 2024 18th Conference of the International Society of Indoor Air Quality and Climate, INDOOR AIR 2024The project has received funding from European Union\u2019s Horizon Europe Research and Innovation programme under Grant Agreement No. 101056883.Peer reviewe

The InChildHealth Walkthrough Survey: towards a standardized characterization of classrooms for indoor air quality studies in Europe

The Horizon Europe project InChildHealth aims to study indoor air quality in European schools and the effects of physical, chemical, and microbiological parameters on the health of school children aged 6-13. As European schools can vary considerably in terms of size, age, materials, equipment, heating, ventilation and air conditioning (HVAC), cleaning procedures, etc., a questionnaire was developed for a standardized description of classrooms and schools. It includes 86 mandatory and 82 optional questions, targeting building characteristics and potential sources of exposure to particles, chemicals, and microorganisms. The survey has been implemented digitally with the option of paper-based versions and future data sharing for combined data interpretation. The project foresees the possibility of revisions based on lessons learned from the application in seven European cities. The final version can be adjusted to other microenvironments and used in future indoor air studies in Europe and elsewhere.The project has received funding from the European Union’s Horizon Europe Research and Innovation Programme under Grant Agreement No. 101056883

The InChildHealth Walkthrough Survey - towards a standardized characterization of classrooms for Indoor Air Quality studies in Europe

| openaire: EC/HE/101056883/EU//INCHILDHEALTH Publisher Copyright: © 2024 18th Conference of the International Society of Indoor Air Quality and Climate, INDOOR AIR 2024 - Conference Program and Proceedings. All rights reserved.The Horizon Europe project InChildHealth aims to study indoor air quality in European schools and the effects of physical, chemical and microbiological parameters on the health of school children aged 6-13. As schools in Europe can vary considerably in terms of size, age, materials, equipment, heating, ventilation and air conditioning (HVAC), cleaning procedures etc., a questionnaire was developed for a standardized description of classrooms and schools. It includes 86 mandatory and 82 optional questions, targeting building characteristics and potential sources of exposure to particles, chemicals and microorganisms. The survey has been implemented digitally with the option of paper-based versions and future data sharing for combined data interpretation. The project foresees the possibility of revisions based on lessons learnt from the application in seven European cities. The final version can be adjusted to other microenvironments and used in future indoor air studies in Europe and elsewhere.Peer reviewe

Surgical and postmortem pathology studies: contribution for the investigation of temporal lobe epilepsy

Pathology studies in epilepsy patients bring useful information for comprehending the physiopathology of various forms of epilepsy, as well as aspects related to response to treatment and long-term prognosis. These studies are usually restricted to surgical specimens obtained from patients with refractory focal epilepsies. Therefore, most of them pertain to temporal lobe epilepsy (TLE) with mesial temporal sclerosis (MTS) and malformations of cortical development (MCD), thus providing information of a selected group of patients and restricted regions of the brain. Postmortem whole brain studies are rarely performed in epilepsy patients, however they may provide extensive information on brain pathology, allowing the analysis of areas beyond the putative epileptogenic zone. In this article, we reviewed pathology studies performed in epilepsy patients with emphasis on neuropathological findings in TLE with MTS and MCD. Furthermore, we reviewed data from postmortem studies and discussed the importance of performing these studies in epilepsy populations