'Join Us On Our Journey': developing a new model of care for children and young people with type 1 diabetes Final report for NHS Diabetes

The aims of this research were to develop a model of care that will deliver the aspirations of the policy document, ‘Making Every Young Person with Diabetes Matter’ and improve the care provision for children and young people with Type 1 diabetes in England. Children and young people with Type 1 diabetes, their families and professionals, in nine acute trusts throughout the Yorkshire and the Humber region, participated in talking group discussions and individual interviews to find out about their experiences of diabetes care provision. Findings show that there are certain aspects of the care pathway that need to be addressed. In particular, diabetes care, resources, education, psychological support, school/college and transition were found to be the main areas of concern. Recommendations have been made indicating how current practice needs to change if the care of children and young people with Type 1 diabetes is to improve

Temporal Evolution of the Scattering Polarization of the CaII IR Triplet in Hydrodynamical Models of the Solar Chromosphere

Velocity gradients in a stellar atmospheric plasma have an impact on the anisotropy of the radiation field that illuminates each point within the medium, and this may in principle influence the scattering line polarization that results from the induced atomic level polarization. Here we analyze the emergent linear polarization profiles of the Ca II infrared triplet after solving the radiative transfer problem of scattering polarization in time-dependent hydrodynamical models of the solar chromosphere, taking into account the impact of the plasma macroscopic velocity on the atomic level polarization. We discuss the influence that the velocity and temperature shocks in the considered chromospheric models have on the temporal evolution of the scattering polarization signals of the Ca II infrared lines, as well as on the temporally averaged profiles. Our results indicate that the increase of the linear polarization amplitudes caused by macroscopic velocity gradients may be significant in realistic situations. We also study the effect of the integration time, the microturbulent velocity and the photospheric dynamical conditions, and discuss the feasibility of observing with large-aperture telescopes the temporal variation of the scattering polarization profiles. Finally, we explore the possibility of using the differential Hanle effect in the IR triplet of Ca II with the intention of avoiding the characterization of the zero-field polarization to infer magnetic fields in dynamic situations.Comment: 12 pages, 9 figures. Accepted for publication in ApJ. New figure added, typos correcte

Mind the partisan trust gap: why the 2016 elections are making some Americans worse off

How do we determine whether or not we should trust someone we don’t know? Often we use shortcuts, and party affiliation is one of them. People are less likely to trust someone who is part of a political party they oppose than they are to trust someone who is part of a political party they support – something known as the “partisan trust gap”. Using a multi-country study of partisan trust, Ryan Carlin and Gregory Love find that the more polarized people think their country’s politics are, the wider their partisan trust gap. Such trust gaps are important, as they reduce the ability of elites to reach a compromise and to tackle policy challenges

Pathway-Based Genomics Prediction using Generalized Elastic Net.

We present a novel regularization scheme called The Generalized Elastic Net (GELnet) that incorporates gene pathway information into feature selection. The proposed formulation is applicable to a wide variety of problems in which the interpretation of predictive features using known molecular interactions is desired. The method naturally steers solutions toward sets of mechanistically interlinked genes. Using experiments on synthetic data, we demonstrate that pathway-guided results maintain, and often improve, the accuracy of predictors even in cases where the full gene network is unknown. We apply the method to predict the drug response of breast cancer cell lines. GELnet is able to reveal genetic determinants of sensitivity and resistance for several compounds. In particular, for an EGFR/HER2 inhibitor, it finds a possible trans-differentiation resistance mechanism missed by the corresponding pathway agnostic approach

Competition and Enterprise Performance in Transition Economies: Evidence from a Cross-country Survey

This paper uses a survey of 3,300 firms in 25 transition countries to shed light on the factors that influence restructuring by firms and their subsequent performance as measured by growth in sales and in sales per employee over a three-year period. We begin by surveying what a decade of transition has taught us about the factors that determine how firms respond to the new market environment. We go on to analyse the impact on performance of ownership, soft budget constraints, the general business environment and a range of measures of the intensity of competition as perceived by a firm. We find that competition has an important and non-monotonic effect on the growth of sales and of labour productivity: some degree of perceived market power is associated with higher sales growth, but competitive pressure is also important. Similar competition effects are found upon firms' decisions to develop and improve their products, but market power has an unambiguously negative impact on purely defensive (cost-reducing) restructuring activity. New firms have grown relatively fast, but among old firms ownership per se has no significant relationship to performance (though state-owned firms have engaged in significantly less development of new products). Soft budget constraints have a broadly negative and the business environment a broadly positive impact on restructuring and performance.http://deepblue.lib.umich.edu/bitstream/2027.42/39760/3/wp376.pd

Variable-speed Generators with Flux Weakening

A cost-competitive, permanent-magnet 20 kW generator is designed such that the following criteria are satisfied: an (over) load capability of at least 30 kW over the entire speed range of 60-120 rpm, generator weight of about 550 lbs with a maximum radial stator flux density of 0.82 T at low speed, unity power factor operation, acceptably small synchronous reactances and operation without a gear box. To justify this final design four different generator designs are investigated: the first two designs are studied to obtain a speed range from 20 to 200 rpm employing rotor field weakening, and the latter two are investigated to obtain a maximum speed range of 40 to 160 rpm based on field weakening via the stator excitation. The generator reactances and induced voltages are computed using finite element/difference solutions. Generator losses and efficiencies are presented for all four designs at rated temperature of Tr=120C

High-power AlGaAs channeled substrate planar diode lasers for spaceborne communications

A high power channeled substrate planar AlGaAs diode laser with an emission wavelength of 8600 to 8800 A was developed. The optoelectronic behavior (power current, single spatial and spectral behavior, far field characteristics, modulation, and astigmatism properties) and results of computer modeling studies on the performance of the laser are discussed. Lifetest data on these devices at high output power levels is also included. In addition, a new type of channeled substrate planar laser utilizing a Bragg grating to stabilize the longitudinal mode was demonstrated. The fabrication procedures and optoelectronic properties of this new diode laser are described

Gpr126/Adgrg6 has Schwann cell autonomous and nonautonomous functions in peripheral nerve injury and repair

Schwann cells (SCs) are essential for proper peripheral nerve development and repair, although the mechanisms regulating these processes are incompletely understood. We previously showed that the adhesion G protein-coupled receptor Gpr126/Adgrg6 is essential for SC development and myelination. Interestingly, the expression of Gpr126 is maintained in adult SCs, suggestive of a function in the mature nerve. We therefore investigated the role of Gpr126 in nerve repair by studying an inducible SC-specific Gpr126 knock-out mouse model. Here, we show that remyelination is severely delayed after nerve-crush injury. Moreover, we also observe noncell-autonomous defects in macrophage recruitment and axon regeneration in injured nerves following loss of Gpr126 in SCs. This work demonstrates that Gpr126 has critical SC-autonomous and SC-nonautonomous functions in remyelination and peripheral nerve repair. SIGNIFICANCE STATEMENT Lack of robust remyelination represents one of the major barriers to recovery of neurological functions in disease or following injury in many disorders of the nervous system. Here we show that the adhesion class G protein-coupled receptor (GPCR) Gpr126/Adgrg6 is required for remyelination, macrophage recruitment, and axon regeneration following nerve injury. At least 30% of all approved drugs target GPCRs; thus, Gpr126 represents an attractive potential target to stimulate repair in myelin disease or following nerve injury