68Ga-PSMA PET/CT in recurrent prostate cancer after radical prostatectomy using PSMA-RADS version 2.0

Background: 68Ga-PSMA PET/CT is superior to standard-of-care imaging for detecting regional and distant metastatic recurrent prostate cancer. The objective of our study was to evaluate the performance of 68Ga-PSMAPET/CT in our patient population, using the new PSMA-RADS version 2.0. Methods: A total of 128 patients scanned with 68Ga-PSMA PET/CT for detection of recurrence after RP were analyzed with PSMA-RADS version 2.0. For the analysis of the detection rate, categories PSMA-RADS 3 to 5 were considered as “positive for malignancy” and 1–2 as “negative”. Results: According to PSMA-RADS v2.0, we classified patients as follows: 23 patients without PSMA-RADS because they were negative; PSMA-RADS 1: 10 patients; PSMA-RADS 2: 4 patients; PSMA-RADS 3A: 11 patients; PSMA-RADS 3B: 2 patients; PSMA-RADS 3C: 2 patients; PSMA-RADS 3D: 2 patients; PSMA-RADS 4: 13 patients; PSMA-RADS 5: 61 patients. Conclusions: The overall detection rate of 68Ga-PSMA PET/CT was 71%. By dividing the patients into fourgroups according to PSA level before examination, we obtained the following detection rates: PSA < 0.2 ng/mL 38%; 0.2 ≤ PSA < 0.5 ng/mL 57%; 0.5 ≤ PSA ≤ 1 ng/mL 77%; and PSA > 1 ng/mL 95%. Conclusion: Using PSMA-RADS version 2.0, we obtained detection rate values comparable with recent literature both in absolute terms and in relation to different PSA levels

Estudios preliminares de la perla de la vid Margarodes vitis (hemiptera: margarodidae) en viñedos de La Consulta, Mendoza, Argentina

La perla de la vid, Margarodes vitis (Philippi), es un insecto subterráneo que se alimenta de las raíces de Vitis vinifera. Los daños se manifiestan como un decaimiento progresivo causando la muerte de la planta. El estudio de la distribución espacial de los insectos brinda información fundamental para implementar programas de Manejo Integrado de Plagas. El objetivo del trabajo fue determinar el ciclo de vida, la relación síntomas en las plantas-número de insectos/kg suelo y la distribución espacial del insecto. Se realizaron muestreos quincenales en La Consulta, Mendoza desde setiembre de 2012 a marzo de 2013. Las muestras se procesaron en laboratorio registrándose el número de quistes/1000 g de suelo. Se observaron hembras y huevos, pero no ninfas de primer estadio, desde fines de noviembre hasta principios de enero. Se usaron varios índices de dispersión. También se estimaron los coeficientes a y b de la Ley Potencial de Taylor y α y β de la Regresión de Iwao. M. vitis siempre presentó una distribución agregada. El análisis del coeficiente de correlación de Spearman mostró una relación significativa (P<0,0001) entre el número de quistes y la escala de daños. Esta información permitirá desarrollar planes de muestreo y estrategias de control.The ground pearl, Margarodes vitis (Philippi), is a subterranean sucking plant insect that feeds on the roots of Vitis vinifera. Damages are shown as a progressive decline, causing the death of the plant. Study of insect spatial patterns provides critical information to implement an Integrated Pest Management program. The aim of this study was to determine the lifecycle, symptoms related plants insect-number / kg soil and spatial pattern of the insect. Twice a month samplings were carried out, between September 2012 to March 2013 in La Consulta, Mendoza.The samples were processed in laboratory and the number of cysts / 1000 g soil was registered. Females and eggs, but not first instar nymphs were observed from late November to early January. Several dispersion indexes were applied .The a and b coefficients of Taylor’s Power Law and α and β of the Iwao´s Regression coefficients were also estimated. Always, M. vitis showed an aggregate pattern. An analysis of Spearman´s correlation coefficient showed that significant differences (P< 0.0001) occurred between number of cysts and damage scale. This information is useful to develop sampling plans and control strategies.Inst. de Microbiología y Zoología Agrícola IMyZAFil: Gonzalez, M.F. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Microbiología y Zoología Agrícola; ArgentinaFil: Casciani, Juan Carlos. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Mendoza; ArgentinaFil: Pareja Perdomo, Mariano. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Mendoza; ArgentinaFil: Prior, C. IES N.° 9-015 Valle de Uco; ArgentinaUCOFil: Peinado Manzur, Horacio Hernan. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria La Consulta; Argentin

The Difficulty of Detecting Occult Metastases in Patients with Potentially Resectable Pancreatic Cancer:Development and External Validation of a Preoperative Prediction Model

Occult metastases are detected in 10–15% of patients during exploratory laparotomy for pancreatic cancer. This study developed and externally validated a model to predict occult metastases in patients with potentially resectable pancreatic cancer. Model development was performed within the Dutch Pancreatic Cancer Audit, including all patients operated for pancreatic cancer (January 2013–December 2017). Multivariable logistic regression analysis based on the Akaike Information Criteria was performed with intraoperative pathologically proven metastases as the outcome. The model was externally validated with a cohort from the University Hospital of Verona (January 2013–December 2017). For model development, 2262 patients were included of whom 235 (10%) had occult metastases, located in the liver (n = 143, 61%), peritoneum (n = 73, 31%), or both (n = 19, 8%). The model included age (OR 1.02, 95% CI 1.00–1.03), BMI (OR 0.96, 95% CI 0.93–0.99), preoperative nutritional support (OR 1.73, 95% CI 1.01–2.74), tumor diameter (OR 1.60, 95% CI 1.04–2.45), tumor composition (solid vs. cystic) (OR 2.33, 95% CI 1.20–4.35), and indeterminate lesions on preoperative imaging (OR 4.01, 95% CI 2.16–7.43). External validation showed poor discrimination with a C-statistic of 0.56. Although some predictor variables were significantly associated with occult metastases, the model performed insufficiently at external validation.</p

Clinical nutrition in surgical oncology: Young AIOM-AIRO-SICO multidisciplinary national survey on behalf of NutriOnc research group

Malnutrition is a common condition in cancer patients which is usually associated with functional limitations, as well as increased morbidity and mortality. Based on the support of the young sections of Italian Association of Medical Oncology (AIOM), Italian Association of Radiotherapy and Clinical Oncology (AIRO) and Italian Society of Surgical Oncology (SICO) merged into the NutriOnc Research Group, we performed a multidisciplinary national survey with the aim to define the awareness of nutritional issues among healthcare professionals delivering anticancer care. The questionnaire was organized in four sections, as follows: Knowledge and practices regarding Nutritional Management of cancer patients; Timing of screening and assessment of Nutritional Status; Nutritional Treatment and prescription criteria; Immunonutrition and educational topics. The modules focused on esophagogastric, hepato-bilio-pancreatic and colorectal malignancies. Overall, 215 physicians completed the survey. As regards the management of Nutritional Status of cancer patients, many responders adopted the ERAS program (49.3%), while a consistent number of professionals did not follow a specific validated nutritional care protocol (41.8%), mainly due to lack of educational courses (14.5%) and financial support (15.3%). Nearly all the included institutions had a multidisciplinary team (92%) to finalize the treatment decision-making. Cancer patients routinely underwent nutritional screening according to 57.2% of interviewed physicians. The timing of nutritional assessment was at diagnosis (37.8%), before surgery (25.9%), after surgery (16.7%), before radiochemotherapy (13.5%) and after radiochemotherapy (7%). Most of the responders reported that nutritional status was assessed throughout the duration of cancer treatments (55.6%). An important gap between current delivery and need of nutritional assessment persists. The development of specific and defined care protocols and the adherence to these tools may be the key to improving nutritional support management in clinical practice

Rendimiento de cultivares de Arveja (Pisum sativum, L) en diferentes ambientes de la República Argentina. Campaña 2017-2018

Las exportaciones de arveja argentina se redujeron en 2017 respecto del año 2016, con una caída de 14 %. A pesar de ello la demanda internacional crece todos los años pero Argentina no logra incrementar la participación, entre otros factores debido a la poco atractiva ecuación económica del cultivo como para que los productores incrementen la oferta. Los precios de arveja verde se modificaron a la suba, a partir de la mayor demanda por la reactivación del principal comprador de la producción nacional, Brasil, pero está lejos de ser un precio tentador.EEA PergaminoFil: Prieto, Gabriel María. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Oliveros. Agencia de Extensión Rural Arroyo Seco; ArgentinaFil: Alamo, Juan Facundo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Famaillá. Agencia de Extensión Rural Trancas; ArgentinaFil: Appella, Cristian Manuel. Instituto Nacional de Tecnología Agropecuaria (INTA). Chacra Experimental Integrada Barrow; Argentina.Fil: Avila, F. CREA. Consorcio Regional de Experimentación Agrícola; ArgentinaFil: Balbo, R. Universidad Nacional de Córdoba; ArgentinaFil: Brassesco, Raul Francisco. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Paraná. Agencia de Extensión Rural Victoria; ArgentinaFil: Buschittari, D. Agricultores Federados Argentinos (AFA). Sociedad Cooperativa Limitada (SCL); ArgentinaFil: Casciani, Andres. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Oliveros. Agencia de Extensión Rural Arroyo Seco; ArgentinaFil: Espósito, María Andrea. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Oliveros; ArgentinaFil: Fariña, Leandro. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Agencia Regional de Desarrollo Productivo; ArgentinaFil: Fekete, Ana Cecilia. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Salta; ArgentinaFil: Figueroa, Enrique Alberto. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Mercedes; ArgentinaFil: Frolla, Franco Daniel. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bordenave; ArgentinaFil: Maggio, J.C. Agrar del Sur; ArgentinaFil: Maggio, María Elisa. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Salta; ArgentinaFil: Martinez, María José. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Manfredi; ArgentinaFil: Martins, Luciano. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela. Agencia de Extensión Rural Galvez; ArgentinaFil: Pérez, Gonzalo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Pergamino. Agencia de Extensión Rural Bolívar; Argentina.FiL: Prece, Natalia María. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Pergamino. Departamento de Agronomía; ArgentinaFil: Vallejo, Maximiliano. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Paraná. Agencia de Extensión Rural Victoria; Argentina.Fil: Zgrablich, A. Universidad Nacional de Córdoba; Argentin

‘The world is best experienced at 18 mph’. The psychological wellbeing effects of cycling in the countryside: an Interpretative Phenomenological Analysis

Green Exercise (GE) refers to physical activity conducted whilst simultaneously engaging the natural environment. A substantial body of literature has now been accumulated that establishes that carrying out exercise in this way has significantly greater psychological wellbeing benefits than the non-GE equivalent. Hitherto, seldom has consideration been given to the individual meanings that doing GE has. This study, therefore, sought to understand the lived experience of the phenomenon amongst a group of serious male recreational road bicyclists aged between mid-30s and early 50s who routinely rode in the countryside. Eleven bicyclists participated in semi-structured interviews. Data were analysed using Interpretative Phenomenological Analysis. This revealed themes of mastery and uncomplicated joys; my place to escape and rejuvenate; and alone but connected. Findings indicate that green-cycling served to enhance the participants’ sense of wellbeing and in doing so helped them cope with the mental challenges associated with their lives. It is suggested that green-cycling merges the essential qualities of natural surroundings – including its aesthetic, feelings of calm and a chance for exploration – with the potential for physical challenge and, facilitated by modern technology, opportunities for prosocial behaviours. It also identifies how green-cycling may influence self-determined behaviours towards exercise regulation, suggesting more satisfying and enduring exercise experiences