Technology Transfer between Research Units and Enterprises. An approach to centred model in the impact on territorial strategic targets.

International audienceThe purpose of this paper is to present significant advances on a research project under development by the authors. The project, analyses the bases for a model that evaluates technology transfer between research units and companies; it does it, by trimming the impact on strategic targets, investigation units, companies and the region itself in which they are immersed by analyzing the impact in terms of their development and consequential benefits for the society. It is tried to diffuse the preliminary design of a model, the research method and tools that facilitate the multidimensional approaches that are able to involve actors who are of very different nature (partnerships) and that allow generating and managing knowledge in a participative way. This would encourage an improvement in the dialogue between science and society, defining specific research activities and as a final step, taking actions without losing in mind, the goal of favouring and encouraging the ownership of this knowledge by the territorial actors and the people who eventually will contribute to the improvement of the territorial governance. This model underlines the scientific world and territorial complementary action, the participative research-action activity could be defined as a kind of research behaviour in which researchers and territorial actors are involved in pursue of a double objective: first of all, a scientific one which would be represented by improving the knowledge on a concrete aspect of the territorial structure and/or dynamics; and a second one, that would embrace the acting and resolution of concrete problems of a definite region or territory

Undifferentiated Sarcoma of the Liver in the Adult

Os AA apresentam um caso clínico de sarcoma indiferenciado do fígado no adulto com metástases pulmonares, cardíacas e com recidiva local hepática. Salienta-se a contribuição dos exames complementares de diagnóstico, com especial relevo para a ecocardiografia no diagnóstico precoce de metástases intracardiacas. Não encontrámos qualquer outro caso descrito na literatura portuguesa

Sheath parameters for non-Debye plasmas: simulations and arc damage

This paper describes the surface environment of the dense plasma arcs that damage rf accelerators, tokamaks and other high gradient structures. We simulate the dense, non-ideal plasma sheath near a metallic surface using Molecular Dynamics (MD) to evaluate sheaths in the non-Debye region for high density, low temperature plasmas. We use direct two-component MD simulations where the interactions between all electrons and ions are computed explicitly. We find that the non-Debye sheath can be extrapolated from the Debye sheath parameters with small corrections. We find that these parameters are roughly consistent with previous PIC code estimates, pointing to densities in the range $10^{24} - 10^{25}\mathrm{m}^{-3}$. The high surface fields implied by these results could produce field emission that would short the sheath and cause an instability in the time evolution of the arc, and this mechanism could limit the maximum density and surface field in the arc. These results also provide a way of understanding how the "burn voltage" of an arc is generated, and the relation between self sputtering and the burn voltage, while not well understood, seems to be closely correlated. Using these results, and equating surface tension and plasma pressure, it is possible to infer a range of plasma densities and sheath potentials from SEM images of arc damage. We find that the high density plasma these results imply and the level of plasma pressure they would produce is consistent with arc damage on a scale 100 nm or less, in examples where the liquid metal would cool before this structure would be lost. We find that the sub-micron component of arc damage, the burn voltage, and fluctuations in the visible light production of arcs may be the most direct indicators of the parameters of the dense plasma arc, and the most useful diagnostics of the mechanisms limiting gradients in accelerators.Comment: 8 pages, 16 figure

Models of Dynamical Supersymmetry Breaking with Gauged U(1)RU(1)_R Symmetry

We present simple models of dynamical supersymmetry breaking with gauged U(1)_R symmetry. The minimal supersymmetric standard model and supersymmetric SU(5) GUT are considered as the visible sector. The anomaly cancellation conditions for U(1)_R are investigated in detail and simple solutions of the R-charge assignments are found. We show that this scenario of dynamical supersymmetry breaking is phenomenologically viable with the gravitino mass of order 1 TeV or 10 TeV.Comment: 15 pages, uses REVTEX macro, No figure

R-symmetry, Yukawa textures and anomaly mediated supersymmetry breaking

We explore, in the MSSM context, an extension of the Anomaly Mediated Supersymmetry Breaking solution for the soft scalar masses that is possible if the underlying theory has a gauged R-symmetry. The slepton mass problem characteristic of the scenario is resolved, and a context for the explanation of the fermion mass hierarchy provided.Comment: 12 pages, Plain TeX, Uses Harvmac (big). More references added, and improved discussion of FCNC

A Constrained Standard Model from a Compact Extra Dimension

A SU(3) \times SU(2) \times U(1) supersymmetric theory is constructed with a TeV sized extra dimension compactified on the orbifold S^1/(Z_2 \times Z_2'). The compactification breaks supersymmetry leaving a set of zero modes which correspond precisely to the states of the 1 Higgs doublet standard model. Supersymmetric Yukawa interactions are localized at orbifold fixed points. The top quark hypermultiplet radiatively triggers electroweak symmetry breaking, yielding a Higgs potential which is finite and exponentially insensitive to physics above the compactification scale. This potential depends on only a single free parameter, the compactification scale, yielding a Higgs mass prediction of 127 \pm 8 GeV. The masses of the all superpartners, and the Kaluza-Klein excitations are also predicted. The lightest supersymmetric particle is a top squark of mass 197 \pm 20 GeV. The top Kaluza-Klein tower leads to the \rho parameter having quadratic sensitivity to unknown physics in the ultraviolet.Comment: 31 pages, Latex, 2 eps figures, minor correction

Yukawa Textures and Anomaly Mediated Supersymmetry Breaking

We present a detailed analysis of how a mixed-anomaly-free U(1) symmetry can be used to both resolve the slepton mass problem associated with Anomaly Mediated Supersymmetry Breaking and generate the fermion mass hierarchy via the Froggatt-Nielsen mechanism. Flavour changing neutral currents problems are evaded by a specific form of the Yukawa textures.Comment: 33 pages, TeX, Uses Harvmac (big) and epsf. Added references and minor changes and corrections. Improved texture discussio

Lepton Flavor Violation in Supersymmetric SO(10) Grand Unified Models

The study for lepton flavor violation combined with the neutrino oscillation may provide more information about the lepton flavor structure of the grand unified theory. In this paper, we study two lepton flavor violation processes, $\tau\to \mu\gamma$ and $Z\to \tau\mu$, in the context of supersymmetric SO(10) grand unified models. We find the two processes are both of phenomenological interest. In particular the latter may be important in some supersymmetric parameter space where the former is suppressed. Thus, Z-dacay may offer another chance for looking for lepton flavor violation.Comment: 26 pages, 10 figure

ADC Nonlinearity Correction for the Majorana Demonstrator

Imperfections in analog-to-digital conversion (ADC) cannot be ignored when signal digitization requirements demand both wide dynamic range and high resolution, as is the case for the Majorana Demonstrator 76Ge neutrinoless double-beta decay search. Enabling the experiment's high-resolution spectral analysis and efficient pulse shape discrimination required careful measurement and correction of ADC nonlinearities. A simple measurement protocol was developed that did not require sophisticated equipment or lengthy data-taking campaigns. A slope-dependent hysteresis was observed and characterized. A correction applied to digitized waveforms prior to signal processing reduced the differential and integral nonlinearities by an order of magnitude, eliminating these as dominant contributions to the systematic energy uncertainty at the double-beta decay Q value

Novel prokaryotic expression of thioredoxin-fused insulinoma associated protein tyrosine phosphatase 2 (IA-2), its characterization and immunodiagnostic application

Background The insulinoma associated protein tyrosine phosphatase 2 (IA-2) is one of the immunodominant autoantigens involved in the autoimmune attack to the beta-cell in Type 1 Diabetes Mellitus. In this work we have developed a complete and original process for the production and recovery of the properly folded intracellular domain of IA-2 fused to thioredoxin (TrxIA-2ic) in Escherichia coli GI698 and GI724 strains. We have also carried out the biochemical and immunochemical characterization of TrxIA-2icand design variants of non-radiometric immunoassays for the efficient detection of IA-2 autoantibodies (IA-2A). Results The main findings can be summarized in the following statements: i) TrxIA-2ic expression after 3 h of induction on GI724 strain yielded ≈ 10 mg of highly pure TrxIA-2ic/L of culture medium by a single step purification by affinity chromatography, ii) the molecular weight of TrxIA-2ic (55,358 Da) could be estimated by SDS-PAGE, size exclusion chromatography and mass spectrometry, iii) TrxIA-2ic was properly identified by western blot and mass spectrometric analysis of proteolytic digestions (63.25 % total coverage), iv) excellent immunochemical behavior of properly folded full TrxIA-2ic was legitimized by inhibition or displacement of [35S]IA-2 binding from IA-2A present in Argentinian Type 1 Diabetic patients, v) great stability over time was found under proper storage conditions and vi) low cost and environmentally harmless ELISA methods for IA-2A assessment were developed, with colorimetric or chemiluminescent detection. Conclusions E. coli GI724 strain emerged as a handy source of recombinant IA-2ic, achieving high levels of expression as a thioredoxin fusion protein, adequately validated and applicable to the development of innovative and cost-effective immunoassays for IA-2A detection in most laboratories.Fil: Guerra, Luciano Lucas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; ArgentinaFil: Faccinetti, Natalia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; ArgentinaFil: Trabucchi, Aldana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; ArgentinaFil: Rovitto, Bruno David. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; ArgentinaFil: Sabljic, Adriana Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; ArgentinaFil: Poskus, Edgardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; ArgentinaFil: Iacono, Ruben Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; ArgentinaFil: Valdez, Silvina Noemi. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; Argentin