Optical coherence tomography analysis of filtering blebs after long-term, functioning trabeculectomy and XEN® stent implant.

The purpose of this study was to use Triton® SweptSource OCT to evaluate the morphology of blebs formed when eyes are treated with XEN® implants and to compare these with the blebs in successfully functioning eyes after trabeculectomy (TB) and with eyes of healthy controls. A cross-sectional, observational study. We analyzed 25 eyes, 15 after TB and 10 with XEN® implants, comparing them with 23 healthy eyes (controls). We evaluated the conjunctival morphology of the eyes using AS-OCT. The main parameters evaluated were bleb height, sub-epithelial fibrosis, epithelial thickness, and changes in intraocular pressure (IOP). We found that the filtering blebs formed in eyes in which a XEN® stent was implanted were significantly flatter (bleb height 417 ± 183 μm) than the blebs formed in TB eyes (bleb height 618 ± 256 μm, p  0.05). Filtering blebs obtained after the introduction of a XEN® stent were morphologically distinct to those produced by TB, and they are more similar to the healthy conjunctiva

Oleuropein and its peracetylated derivative negatively regulate osteoclastogenesis by controlling the expression of genes involved in osteoclast differentiation and function

OL and Per-OL impair transcriptional gene circuits able to support osteoclastogenesis from human blood monocytes.</p

A locked mode indicator for disruption prediction on JET and ASDEX upgrade

The aim of this paper is to present a signal processing algorithm that, applied to the raw Locked Mode signal, allows us to obtain a disruption indicator in principle exploitable on different tokamaks. A common definition of such an indicator for different machines would facilitate the development of portable systems for disruption prediction, which is becoming of increasingly importance for the next tokamak generations. Moreover, the indicator allows us to overcome some intrinsic problems in the diagnostic system such as drift and offset. The behavior of the proposed indicator as disruption predictor, based on crossing optimized thresholds of the signal amplitude, has been analyzed using data of both JET and ASDEX Upgrade experiments. A thorough analysis of the disruption prediction performance shows how the indicator is able to recover some missed and tardy detections of the raw signal. Moreover, it intervenes and corrects premature or even wrong alarms due to, e.g., drifts and/or offsets