Spoken vocabulary outcomes of toddlers with developmental delay receiving parent-coached augmented language intervention: A phonetic description and analysis

This study examined the characteristics and predictors of speech sound development of 48 children with developmental delay after participating in parent-coached language interventions. Spoken target vocabulary words were identified for each child and transcribed phonetically. Phonemes were categorized by developmental sound classes and examined for speech sound errors. In general, the majority of children’s phonemes and speech-sound errors were age appropriate at the end of intervention and were not significantly different across intervention groups. When baseline predictors were examined, only intervention group and age were significant predictors of the number of spoken target vocabulary words at the end of intervention. Outcomes of this study suggest that clinicians should use AAC with young children with complex communication needs (CCN) to support expressive language development without fear that it will impair articulation skills

Studi Eksperimental Karakteristik Beton Mutu Tinggi dengan Memanfaatkan Limbah Fly Ash dan Coco Fiber

The issue of environmental friendliness has become very popular recently. Various industrial sectors must pay attention to environmental factors as a global sustainability goal. In the construction industry sector, concrete is a much-needed material in making building structures. Concrete becomes environmentally friendly by utilizing waste as a substitute for some of the ingredients. This research uses fly ash and coconut fiber. This study aims to determine the effect of renewable innovation in the addition of fly ash and coco fiber waste on the value of compressive strength and flexural strength of concrete and to determine the composition of the most optimum percentage of waste addition, as well as the resulting crack pattern. This research uses the international standard ACI 211.4R-93, which is an experiment with the addition of 15% fly ash and variations in the addition of coconut fiber 0.5%, 1%, 1.5%, and 2%. The concrete quality planning in this study is 40 MPa with concrete treatment for 28 days and 56 days. This test uses cylindrical test objects (15cm x 30cm) with a total of 30 samples for compressive strength testing and beams (60cm x 15cm x 15cm) with a total of 30 samples for flexural strength testing. The results obtained in this study are the optimum compressive strength found in the variation of adding 1.5% fiber and 15% fly ash at 56 days of concrete age of 33.12 MPa. The highest concrete flexural strength value is found in the 2% fiber addition variation

Monitoring and Failure Analysis of Corroded Bridge Cables under Fatigue Loading Using Acoustic Emission Sensors

Cables play an important role in cable-stayed systems, but are vulnerable to corrosion and fatigue damage. There is a dearth of studies on the fatigue damage evolution of corroded cable. In the present study, the acoustic emission (AE) technology is adopted to monitor the fatigue damage evolution process. First, the relationship between stress and strain is determined through a tensile test for corroded and non-corroded steel wires. Results show that the mechanical performance of corroded cables is changed considerably. The AE characteristic parameters for fatigue damage are then established. AE energy cumulative parameters can accurately describe the fatigue damage evolution of corroded cables. The failure modes in each phase as well as the type of acoustic emission source are determined based on the results of scanning electron microscopy. The waveform characteristics, damage types, and frequency distribution of the corroded cable at different damage phases are collected. Finally, the number of broken wires and breakage time of the cables are determined according to the variation in the margin index

Parent-implemented augmented communication intervention and young children with Down syndrome: an exploratory report

IntroductionYoung children with Down syndrome (DS) present with speech and language impairments very early in childhood. Historically, early language intervention for children with DS included manual signs, though recently there has been an interest in the use of speech-generating devices (SGDs). This paper examines the language and communication performance of young children with DS who participated in parent-implemented communication interventions that included SGDs. Specifically, we compared the functional vocabulary usage and communication interaction skills of children with DS who received augmented communication interventions (AC) that included an SGD with those children with DS who received spoken communication intervention (SC).MethodsTwenty-nine children with DS participated in this secondary data analysis. These children were part of one of two longitudinal RCT studies investigating the effectiveness of parent-implemented augmented communication interventions in a larger sample of 109 children with severe communication and language impairments.ResultsThere were significant differences between children with DS in the AC and SC groups in terms of the number and proportion of functional vocabulary targets used and the total vocabulary targets provided during the intervention at sessions 18 (lab)and 24 (home).DiscussionOverall, the AC interventions provided the children with a way to communicate via an SGD with visual-graphic symbols and speech output, while the children in the SC intervention were focused on producing spoken words. The AC interventions did not hinder the children’s spoken vocabulary development. Augmented communication intervention can facilitate the communication abilities of young children with DS as they are emerging spoken communicators

Mitochondrial complex I activity in microglia sustains neuroinflammation

Sustained smouldering, or low-grade activation, of myeloid cells is a common hallmark of several chronic neurological diseases, including multiple sclerosis1. Distinct metabolic and mitochondrial features guide the activation and the diverse functional states of myeloid cells2. However, how these metabolic features act to perpetuate inflammation of the central nervous system is unclear. Here, using a multiomics approach, we identify a molecular signature that sustains the activation of microglia through mitochondrial complex I activity driving reverse electron transport and the production of reactive oxygen species. Mechanistically, blocking complex I in pro-inflammatory microglia protects the central nervous system against neurotoxic damage and improves functional outcomes in an animal disease model in vivo. Complex I activity in microglia is a potential therapeutic target to foster neuroprotection in chronic inflammatory disorders of the central nervous system3

Delivery of a Muscle-Targeted Adeno-Associated Vector Via Ex Vivo Normothermic Perfusion Is Efficient, Durable, and Safe in a Preclinical Porcine Heart Transplant Model

Normothermic ex-vivo organ perfusion (EVP) systems not only provide a physiological environment that preserves donor organ function outside the body but may also serve as platforms for ex-vivo organ modification via gene therapy. In this study, we demonstrated that a rationally designed muscle-tropic recombinant AAV, AAV-SLB101, delivered to the donor heart during brief normothermic EVP achieves durable cardiac transgene expression out to 90 and 120 days post-transplant in a porcine preclinical model. Moreover, transgene expression was detectable as early as 48 h post-transplant. Histological and MRI analyses of the donor myocardium showed no functional or structural impact on the allograft and no off-target gene expression in the recipient. This work will serve as a critical foundation to inform translational studies with therapeutic transgenes to improve allo-, xeno-, and auto-heart transplant outcomes