69 research outputs found
Colours and metallic sheen in beetle shells - A biomimetic search for material structuring principles causing light interference
Can Leadership Be Taught? A Proposal For a Statewide Comprehensive Career and Technical Education Program
This executive position paper proposes recommendations for a statewide comprehensive career and technical education Leadership Development Program. These recommendations are based on the comprehensive Leadership Development Program designed and executed at Sussex Technical High School. The Sussex Tech comprehensive Leadership Development Program design provides innovative scheduling concepts and lessons that promote the leadership and skill competition activities sponsored by the career and technical student organizations: SkillsUSA, Business Professionals of American, Health Occupations Students of America, and FFA. All of the design elements recommended are a direct result of the paradigm shift to create a ubiquitous approach to leadership at Sussex Technical High School. The program is transferable, and it is proposed that all Delaware career and techncial education school districts apply the program design to allow all CTE students the opportunity to experience leadership and be involved in their own personal development through participating in contest activities sponsored by the career and technical student organizations
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SoxB1-2 Regulates Sensory Neuronal Differentiation Through Chromatin Remodeling in the Regenerative Flatworm, Schmidtea mediterranea
Understanding how adult stem cells generate neurons is critical for advancing regenerative medicine, yet few in vivo models allow for the direct study of adult stem cell fate specification. The planarian Schmidtea mediterranea offers a powerful system to investigate these mechanisms, owing to its abundant adult pluripotent stem cells, termed neoblasts, and its capacity to regenerate a molecularly complex nervous system. The SoxB1 family of transcription factors is broadly implicated in ectodermal lineage commitment, and in planarians, the SoxB1 homolog soxB1-2 has been shown to promote neural and epidermal differentiation. However, the mechanisms by which soxB1-2 influences chromatin dynamics and transcriptional programs during adult neurogenesis remain unknown. To address this, we combined ATAC-seq and RNA-seq to assess how soxB1-2 RNAi knockdown alters chromatin accessibility and gene expression. Disrupting soxB1-2 resulted in reduced chromatin accessibility and transcriptional downregulation at neural and epidermal loci, consistent with a pioneer-like role in chromatin priming. We identified 31 candidate downstream targets exhibiting concordant changes in chromatin accessibility and gene expression. Among these, we identified and characterized mecom, a transcription factor potentially involved in regulating mechanosensory signaling genes, along with castor and cux1, which may regulate genes associated with sensory neurons and CNS development and function. Spatially enriched head tissue sampling enabled the detection of soxB1-2-responsive genes within rare neural subtypes that were missed in previous whole-worm assays. These findings offer mechanistic insight into adult ectodermal lineage specification and establish a framework for understanding chromatin-mediated neurogenesis in regenerative systems
Can Leadership Be Taught? A Proposal For a Statewide Comprehensive Career and Technical Education Program
This executive position paper proposes recommendations for a statewide comprehensive career and technical education Leadership Development Program. These recommendations are based on the comprehensive Leadership Development Program designed and executed at Sussex Technical High School. The Sussex Tech comprehensive Leadership Development Program design provides innovative scheduling concepts and lessons that promote the leadership and skill competition activities sponsored by the career and technical student organizations: SkillsUSA, Business Professionals of American, Health Occupations Students of America, and FFA. All of the design elements recommended are a direct result of the paradigm shift to create a ubiquitous approach to leadership at Sussex Technical High School. The program is transferable, and it is proposed that all Delaware career and techncial education school districts apply the program design to allow all CTE students the opportunity to experience leadership and be involved in their own personal development through participating in contest activities sponsored by the career and technical student organizations
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