9 research outputs found

    Modelling flexible thrust performance for trajectory prediction applications in ATM

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    Reduced thrust operations are of widespread use nowadays due to their inherit benefits for engine conservation. Therefore, in order to enable realistic simulation of air traffic management (ATM) scenarios for purposes such as noise and emissions assessment, a model for reduced thrust is required. This paper proposes a methodology for modelling flexible thrust by combining an assumed temperature (AT) polynomial model identified from manufacturer take-off performance data and public thrust models taken from typical ATM performance databases. The advantage of the proposed AT model is that it only depends on the take-off conditions —runway length, airport altitude, temperature, wind, etc. The results derived from this methodology were compared to simulation data obtained from manufacturer’s take-off performance tools and databases. This comparison revealed that the polynomial model provides AT estimations with sufficient accuracy for their use in ATM simulation. The Base of Aircraft Data (BADA) and the Aircraft Noise and Performance (ANP) database were chosen as representative of aircraft performance models commonly used in ATM simulation. It was observed that there is no significant degradation of the overall accuracy of their thrust models when using AT, while there is a correct capture of the corresponding thrust reduction.Peer ReviewedPostprint (published version

    Structural Basis of BRCC36 Function in DNA Repair and Immune Regulation

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    In mammals, ∼100 deubiquitinases act on ∼20,000 intracellular ubiquitination sites. Deubiquitinases are commonly regarded as constitutively active, with limited regulatory and targeting capacity. The BRCA1-A and BRISC complexes serve in DNA double-strand break repair and immune signaling and contain the lysine-63 linkage-specific BRCC36 subunit that is functionalized by scaffold subunits ABRAXAS and ABRO1, respectively. The molecular basis underlying BRCA1-A and BRISC function is currently unknown. Here we show that in the BRCA1-A complex structure, ABRAXAS integrates the DNA repair protein RAP80 and provides a high-affinity binding site that sequesters the tumor suppressor BRCA1 away from the break site. In the BRISC structure, ABRO1 binds SHMT2α, a metabolic enzyme enabling cancer growth in hypoxic environments, which we find prevents BRCC36 from binding and cleaving ubiquitin chains. Our work explains modularity in the BRCC36 DUB family, with different adaptor subunits conferring diversified targeting and regulatory functions.ISSN:1097-2765ISSN:1097-416

    Modelling flexible thrust performance for trajectory prediction applications in ATM

    No full text
    Reduced thrust operations are of widespread use nowadays due to their inherit benefits for engine conservation. Therefore, in order to enable realistic simulation of air traffic management (ATM) scenarios for purposes such as noise and emissions assessment, a model for reduced thrust is required. This paper proposes a methodology for modelling flexible thrust by combining an assumed temperature (AT) polynomial model identified from manufacturer take-off performance data and public thrust models taken from typical ATM performance databases. The advantage of the proposed AT model is that it only depends on the take-off conditions —runway length, airport altitude, temperature, wind, etc. The results derived from this methodology were compared to simulation data obtained from manufacturer’s take-off performance tools and databases. This comparison revealed that the polynomial model provides AT estimations with sufficient accuracy for their use in ATM simulation. The Base of Aircraft Data (BADA) and the Aircraft Noise and Performance (ANP) database were chosen as representative of aircraft performance models commonly used in ATM simulation. It was observed that there is no significant degradation of the overall accuracy of their thrust models when using AT, while there is a correct capture of the corresponding thrust reduction. Peer Reviewe

    Modelling flexible thrust performance for trajectory prediction applications in ATM

    Get PDF
    Reduced thrust operations are of widespread use nowadays due to their inherit benefits for engine conservation. Therefore, in order to enable realistic simulation of air traffic management (ATM) scenarios for purposes such as noise and emissions assessment, a model for reduced thrust is required. This paper proposes a methodology for modelling flexible thrust by combining an assumed temperature (AT) polynomial model identified from manufacturer take-off performance data and public thrust models taken from typical ATM performance databases. The advantage of the proposed AT model is that it only depends on the take-off conditions —runway length, airport altitude, temperature, wind, etc. The results derived from this methodology were compared to simulation data obtained from manufacturer’s take-off performance tools and databases. This comparison revealed that the polynomial model provides AT estimations with sufficient accuracy for their use in ATM simulation. The Base of Aircraft Data (BADA) and the Aircraft Noise and Performance (ANP) database were chosen as representative of aircraft performance models commonly used in ATM simulation. It was observed that there is no significant degradation of the overall accuracy of their thrust models when using AT, while there is a correct capture of the corresponding thrust reduction.Peer ReviewedPostprint (published version

    Modelling flexible thrust performance for trajectory prediction applications in ATM

    No full text
    Reduced thrust operations are of widespread use nowadays due to their inherit benefits for engine conservation. Therefore, in order to enable realistic simulation of air traffic management (ATM) scenarios for purposes such as noise and emissions assessment, a model for reduced thrust is required. This paper proposes a methodology for modelling flexible thrust by combining an assumed temperature (AT) polynomial model identified from manufacturer take-off performance data and public thrust models taken from typical ATM performance databases. The advantage of the proposed AT model is that it only depends on the take-off conditions —runway length, airport altitude, temperature, wind, etc. The results derived from this methodology were compared to simulation data obtained from manufacturer’s take-off performance tools and databases. This comparison revealed that the polynomial model provides AT estimations with sufficient accuracy for their use in ATM simulation. The Base of Aircraft Data (BADA) and the Aircraft Noise and Performance (ANP) database were chosen as representative of aircraft performance models commonly used in ATM simulation. It was observed that there is no significant degradation of the overall accuracy of their thrust models when using AT, while there is a correct capture of the corresponding thrust reduction.Peer Reviewe

    Therapeutic implications of how TNF links apolipoprotein E, phosphorylated tau, α-synuclein, amyloid-β and insulin resistance in neurodegenerative diseases

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