Le syntagme intonatif en langage spontané : étude préliminaire

Une étude portant sur le syntagme intonatif (SI) en langage spontané menée à partir d’un corpus de français du Québec révèle des valeurs relativement stables quant à la longueur de ces SI exprimée en termes d’unités prosodiques minimales. La variabilité rencontrée ne peut être exprimée à l’aide de paramètres sociaux.A study of intonational phrasing (IP) in a corpus of spontaneous speech of Quebec French reveals relatively stable values of length of IPs when expressed in terms of minimal prosodic units. Variability in IP length is not statistically related to the social characteristics of the speakers

Distribution of hammerhead and hammerhead-like RNA motifs through the GenBank

Hammerhead ribozymes previously were found in satellite RNAs from plant viroids and in repetitive DNA from certain species of newts and schistosomes. To determine if this catalytic RNA motif has a wider distribution, we decided to scrutinize the GenBank database for RNAs that contain hammerhead or hammerhead-like motifs. The search shows a widespread distribution of this kind of RNA motif in different sequences suggesting that they might have a more general role in RNA biology. The frequency of the hammerhead motif is half of that expected from a random distribution, but this fact comes From the low CpG representation in vertebrate sequences and the bias of the GenBank for those sequences. Intriguing motifs include those found in several families of repetitive sequences, in the satellite RNA from the carrot red leaf luteovirus, in plant viruses like the spinach latent virus and the elm mottle virus, in animal viruses like the hepatitis E virus and the caprine encephalitis virus, and in mRNAs such as those coding for cytochrome P450 oxidoreductase in the rat and the hamster

L’accentuation québécoise : une approche tonale

Cet article basé sur une analyse de trois locuteurs cherche à apporter des éléments d’éclaircissement sur les notions d’accent tonal et d’accent dynamique et sur les modalités de réalisation des accents tonals complexes dans le français québécois spontané.This article based on an analysis of three speakers aims at clarifying the distinction between stress accent and pitch accent in French and contributes evidence on the modalities of phonetic implementation of a complex pitch accent in spontaneous Quebec French

Nucleozymes

Nucleozymes containing ribonucleotides and deoxyribonucleotides or nucleic acid analogues are described herein. The nucleozymes have catalytic activity and are significantly more resistant to degradation than their all-RNA ribozyme counterparts. Also described are methods for preparing the nucleozymes along with methods of using nucleozymes, e.g., as therapeutic agents

Solvent content of protein crystals from diffraction intensities by Independent Component Analysis

An analysis of the protein content of several crystal forms of proteins has been performed. We apply a new numerical technique, the Independent Component Analysis (ICA), to determine the volume fraction of the asymmetric unit occupied by the protein. This technique requires only the crystallographic data of structure factors as input.Comment: 9 pages, 2 figures, 1 tabl

Interplay between Static and Dynamic Properties of Semifluxons in YBa2Cu3O7−δ 0−π Josephson Junctions

We have investigated the static and dynamic properties of long YBa2Cu3O7-delta 0-pi Josephson junctions and compared them with those of conventional 0 junctions. Scanning SQUID microscope imaging has revealed the presence of a semifluxon at the phase discontinuity point in 0-pi Josephson junctions. Zero field steps have been detected in the current-voltage characteristics of all junctions. Comparison with simulation allows us to attribute these steps to fluxons traveling in the junction for conventional 0 junctions and to fluxon-semifluxon interactions in the case of 0-pi Josephson junctions

Probing the order parameter symmetry in the cuprate high temperature superconductors by SQUID microscopy

The orbital component of the order parameter in the cuprate high-Tc cuprate superconductors is now well established, in large part because of phase sensitive tests. Although it would be desirable to use such tests on other unconventional superconductors, there are a number of favorable factors associated with the properties of the cuprates, and a number of technical advances, that were required for these tests to be successful. In this review I will describe the development of phase sensitive pairing symmetry tests using SQUID microscopy, underlining the factors favoring these experiments in the cuprates and the technical advances that had to be made.Comment: 12 pages, 7 figure, invited review to be published in Comptes Rendus de l'Academie des Sciences (Comptes Rendus Physique

The Effectiveness of the Patient Health Questionnaire-9 Across Cultures

This project has two purposes. First, to evaluate the effectiveness of the Patient Health Questionnaire (PHQ-9) across cultures since it is the standard depression tool used across Mayo Clinic Health System. Second, to develop a Standard of Care that would create consistency in the follow-up provided to patients at Mayo Clinic Health System – Springfield Clinic whose PHQ-9 score reflects signs of depression