Periodic Emission from the Gamma-ray Binary 1FGL J1018.6-5856

Gamma-ray binaries are stellar systems containing a neutron star or black hole with gamma-ray emission produced by an interaction between the components. These systems are rare, even though binary evolution models predict dozens in our Galaxy. A search for gamma-ray binaries with the Fermi Large Area Telescope (LAT) shows that IFGL JI018.6-5856 exhibits intensity and spectral modulation with a 16.6 day period. We identified a variable X-ray counterpart, which shows a sharp maximum coinciding with maximum gamma-ray emission, as well as an 06V f) star optical counterpart and a radio counterpart that is also apparently modulated on the orbital period. IFGL J1018.6-5856 is thus a gamma-ray binary, and its detection suggests the presence of other fainter binaries in the Galaxy

Detection of the Characteristic Pion-Decay Signature in Supernova Remnants

Cosmic rays are particles (mostly protons) accelerated to relativistic speeds. Despite wide agreement that supernova remnants (SNRs) are the sources of galactic cosmic rays, unequivocal evidence for the acceleration of protons in these objects is still lacking. When accelerated protons encounter interstellar material, they produce neutral pions, which in turn decay into gamma rays. This offers a compelling way to detect the acceleration sites of protons. The identification of pion-decay gamma rays has been difficult because high-energy electrons also produce gamma rays via bremsstrahlung and inverse Compton scattering. We detected the characteristic pion-decay feature in the gamma-ray spectra of two SNRs, IC 443 and W44, with the Fermi Large Area Telescope. This detection provides direct evidence that cosmic-ray protons are accelerated in SNRs.Fil: Ackerman, M.. Deutsches Elektronen Synchrotron DESY; AlemaniaFil: Ajello, M.. University of California; Estados UnidosFil: Allafort, A.. University Of Stanford; Estados UnidosFil: Baldini, L.. Universita Degli Studi Di Pisa; ItaliaFil: Ballet, J.. Universit´e Paris Diderot; FranciaFil: Garbiellini, G.. Universit`a di Trieste; ItaliaFil: Baring, M. G.. Rice University; Estados UnidosFil: Bastieri, D.. Universita Di Padova; ItaliaFil: Bechtol, K.. University Of Stanford; Estados UnidosFil: Bellazzini, R.. Istituto Nazionale di Fisica Nucleare; ItaliaFil: Blandford, R. D.. University Of Stanford; Estados UnidosFil: Bloom, E. D.. University Of Stanford; Estados UnidosFil: Bonamente, E.. Universita degli Studi di Perugia; ItaliaFil: Borgland, A. W.. University of Stanford; Estados UnidosFil: Bottaccini, E.. University Of Stanford; Estados UnidosFil: Brandt, T. J.. National Aeronautics And Space Administration. Goddart Institute For Space Studies; Estados UnidosFil: Bregeon, J.. Istituto Nazionale di Fisica Nucleare; ItaliaFil: Brigida, M.. Universit`a e del Politecnico di Bari; ItaliaFil: Bruel, P.. Ecole polytechnique, CNRS; FranciaFil: Buehler, R.. University Of Stanford; Estados UnidosFil: Busetto, G.. Universita di Padova; ItaliaFil: Buson, S..Fil: Caliandro, G. A.. Institut de Ciencies de l’Espai (IEEE-CSIC); EspañaFil: Cameron, R. A.. University Of Stanford; Estados UnidosFil: Caraveo, P. A.. INAF-Istituto di Astrofisica Spaziale e Fisica Cosmica; ItaliaFil: Casandjian, J. M.. Universite Paris Diderot; FranciaFil: Cecchi, C.. Universita degli Studi di Perugia; ItaliaFil: Celic, O.. National Aeronautics And Space Administration. Goddart Institute For Space Studies; Estados UnidosFil: Charles, E.. University Of Stanford; Estados UnidosFil: Cillis, Analia Nilda. Consejo Nacional de Investigaciónes Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Astronomía y Física del Espacio. - Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Astronomía y Física del Espacio; Argentin

Extended Thromboprophylaxis with Betrixaban in Acutely Ill Medical Patients

Background Patients with acute medical illnesses are at prolonged risk for venous thrombosis. However, the appropriate duration of thromboprophylaxis remains unknown. Methods Patients who were hospitalized for acute medical illnesses were randomly assigned to receive subcutaneous enoxaparin (at a dose of 40 mg once daily) for 10±4 days plus oral betrixaban placebo for 35 to 42 days or subcutaneous enoxaparin placebo for 10±4 days plus oral betrixaban (at a dose of 80 mg once daily) for 35 to 42 days. We performed sequential analyses in three prespecified, progressively inclusive cohorts: patients with an elevated d-dimer level (cohort 1), patients with an elevated d-dimer level or an age of at least 75 years (cohort 2), and all the enrolled patients (overall population cohort). The statistical analysis plan specified that if the between-group difference in any analysis in this sequence was not significant, the other analyses would be considered exploratory. The primary efficacy outcome was a composite of asymptomatic proximal deep-vein thrombosis and symptomatic venous thromboembolism. The principal safety outcome was major bleeding. Results A total of 7513 patients underwent randomization. In cohort 1, the primary efficacy outcome occurred in 6.9% of patients receiving betrixaban and 8.5% receiving enoxaparin (relative risk in the betrixaban group, 0.81; 95% confidence interval [CI], 0.65 to 1.00; P=0.054). The rates were 5.6% and 7.1%, respectively (relative risk, 0.80; 95% CI, 0.66 to 0.98; P=0.03) in cohort 2 and 5.3% and 7.0% (relative risk, 0.76; 95% CI, 0.63 to 0.92; P=0.006) in the overall population. (The last two analyses were considered to be exploratory owing to the result in cohort 1.) In the overall population, major bleeding occurred in 0.7% of the betrixaban group and 0.6% of the enoxaparin group (relative risk, 1.19; 95% CI, 0.67 to 2.12; P=0.55). Conclusions Among acutely ill medical patients with an elevated d-dimer level, there was no significant difference between extended-duration betrixaban and a standard regimen of enoxaparin in the prespecified primary efficacy outcome. However, prespecified exploratory analyses provided evidence suggesting a benefit for betrixaban in the two larger cohorts. (Funded by Portola Pharmaceuticals; APEX ClinicalTrials.gov number, NCT01583218. opens in new tab.

Translanguaging and the Transdisciplinary Framework for Language Teaching and Learning in a Multilingual World

The ideas and arguments associated with translanguaging have generated highly energized debates on a number of fundamental issues in linguistics, applied language studies and language education. Aspects of many long-held and apparently settled concepts such as ‘language/s’, ‘code switching’ and ‘Second Language Acquisition/Teaching’ have been fundamentally challenged. As has been acknowledged by scholars in the field, the discussions have at times led to polarized intellectual dispositions premised on particular disciplinary persuasions. In this Critical Review we offer a view from a language education perspective, with particular reference to additional/second/foreign language education in diverse socio-political contexts. We will first provide a historical context for the current debates on translanguaging by drawing attention to earlier efforts to make use of students’ own language to support additional language learning in an era of overwhelming monolingualism in language teaching. After that the discussion moves to the different approaches to translanguaging that have emerged and the pedagogic affordances and values attributed to them. In closing we raise a number conceptual and practice-related issues that would benefit from further deliberation and empirical research. Our view is that we are far from having exhausted the potentialities of translanguaging for educational development that may have impact beyond the classroom

H.E.S.S. programme searching for VHE gamma rays associated with FRBs

Fast Radio Bursts (FRBs) are highly energetic, extremely short-lived bursts of radio flashes. Despite extensive research, the exact cause of these outbursts remains speculative. The high luminosity, short duration, and high dispersion measure of these events suggest they result from extreme, high-energy extragalactic sources, such as highly magnetized and rapidly spinning neutron stars known as magnetars. The number of detected FRBs, including repeating ones, has grown rapidly in recent years. Except for FRB 20200428D, and FRB-like radio burst that is associated to Galactic magnetar SGR 1935+2154, no multi-wavelength counterpart to any FRB has been detected yet. The High Energy Stereoscopic System (H.E.S.S.) telescope has developed a program to follow up FRBs searching for their gamma-ray counterparts, helping to uncover the nature of FRBs and FRB sources. This paper provides an overview of the searches for FRB sources conducted by H.E.S.S., including follow-up observations and simultaneous multi-wavelength campaigns with radio and X-ray observatories. Among the FRB sources observed by H.E.S.S., nine are localized with redshifts ranging between 0.11 and 0.492 from 2015 to 2022. No significant very high energy (VHE) emission was detected during these observations. We report constraints on the VHE luminosity ranging from 1044 erg s-1 and 1048 erg s-1, placing limits on the FRB's region persistent VHE emission and potential FRB afterglow emission across timescales from hours to years

Histone H3 Serine 57 and Lysine 56 Interplay in Transcription Elongation and Recovery from S-Phase Stress

Contains fulltext : 84400.pdf (publisher's version ) (Open Access

Very-high-energy γ -Ray Emission from Young Massive Star Clusters in the Large Magellanic Cloud

The Tarantula Nebula in the Large Magellanic Cloud is known for its high star formation activity. At its center lies the young massive star cluster R136, providing a significant amount of the energy that makes the nebula shine so brightly at many wavelengths. Recently, young massive star clusters have been suggested to also efficiently produce very high-energy cosmic rays, potentially beyond PeV energies. Here, we report the detection of very-high-energy γ-ray emission from the direction of R136 with the High Energy Stereoscopic System, achieved through a multicomponent, likelihood-based modeling of the data. This supports the hypothesis that R136 is indeed a very powerful cosmic-ray accelerator. Moreover, from the same analysis, we provide an updated measurement of the γ-ray emission from 30 Dor C, the only superbubble detected at TeV energies presently. The γ-ray luminosity above 0.5 TeV of both sources is (2–3) × 1035 erg s−1. This exceeds by more than a factor of 2 the luminosity of HESS J1646−458, which is associated with the most massive young star cluster in the Milky Way, Westerlund 1. Furthermore, the γ-ray emission from each source is extended with a significance of >3σ and a Gaussian width of about 30 pc. For 30 Dor C, a connection between the γ-ray emission and the nonthermal X-ray emission appears likely. Different interpretations of the γ-ray signal from R136 are discussed

Unveiling extended gamma-ray emission around HESS J1813-178

Context. HESS J1813-178 is a very-high-energy γ-ray source spatially coincident with the young and energetic pulsar PSR J1813-1749 and thought to be associated with its pulsar wind nebula (PWN). Recently, evidence for extended high-energy emission in the vicinity of the pulsar has been revealed in the Fermi Large Area Telescope (LAT) data. This motivates revisiting the HESS J1813-178 region, taking advantage of improved analysis methods and an extended dataset. Aims. Using data taken by the High Energy Stereoscopic System (H.E.S.S.) experiment and the Fermi-LAT, we aim to describe the γ-ray emission in the region with a consistent model, to provide insights into its origin. Methods. We performed a likelihood-based analysis on 32 hours of H.E.S.S. data and 12 yr of Fermi-LAT data and we fitted a spectro-morphological model to the combined datasets. These results allowed us to develop a physical model for the origin of the observed γ-ray emission in the region. Results. In addition to the compact very-high-energy γ-ray emission centred on the pulsar, we find a significant yet previously undetected component along the Galactic plane. With Fermi-LAT data, we confirm extended high-energy emission consistent with the position and elongation of the extended emission observed with H.E.S.S. These results establish a consistent description of the emission in the region from GeV energies to several tens of TeV. Conclusions. This study suggests that HESS J1813-178 is associated with a γ-ray PWN powered by PSR J1813-1749. A possible origin of the extended emission component is inverse Compton emission from electrons and positrons that have escaped the confines of the pulsar and form a halo around the PWN.</p

High-Statistics Measurement of the Cosmic-Ray Electron Spectrum with H.E.S.S.

Owing to their rapid cooling rate and hence loss-limited propagation distance, cosmic-ray electrons and positrons (CRe) at very high energies probe local cosmic-ray accelerators and provide constraints on exotic production mechanisms such as annihilation of dark matter particles. We present a high-statistics measurement of the spectrum of CRe candidate events from 0.3 to 40 TeV with the High Energy Stereoscopic System, covering 2 orders of magnitude in energy and reaching a proton rejection power of better than 104. The measured spectrum is well described by a broken power law, with a break around 1 TeV, where the spectral index increases from Γ1=3.25±0.02(stat)±0.2(sys) to Γ2=4.49±0.04(stat)±0.2(sys). Apart from the break, the spectrum is featureless. The absence of distinct signatures at multi-TeV energies imposes constraints on the presence of nearby CRe accelerators and the local CRe propagation mechanisms.</p

The Vanishing of the Primary Emission Region in PKS 1510-089

In 2021 July, PKS 1510-089 exhibited a significant flux drop in the high-energy γ-ray (by a factor 10) and optical (by a factor 5) bands and remained in this low state throughout 2022. Similarly, the optical polarization in the source vanished, resulting in the optical spectrum being fully explained through the steady flux of the accretion disk and the broad-line region. Unlike the aforementioned bands, the very-high-energy γ-ray and X-ray fluxes did not exhibit a significant flux drop from year to year. This suggests that the steady-state very-high-energy γ-ray and X-ray fluxes originate from a different emission region than the vanished parts of the high-energy γ-ray and optical jet fluxes. The latter component has disappeared through either a swing of the jet away from the line of sight or a significant drop in the photon production efficiency of the jet close to the black hole. Either change could become visible in high-resolution radio images