Persuasive technology for overcoming food cravings and improving snack choices

This research is partially supported by EPSRC Grant EP/G004560

Stimulation of Na⁺/H⁺ Exchanger Isoform 1 Promotes Microglial Migration

Regulation of microglial migration is not well understood. In this study, we proposed that Na+/H+ exchanger isoform 1 (NHE-1) is important in microglial migration. NHE-1 protein was co-localized with cytoskeletal protein ezrin in lamellipodia of microglia and maintained its more alkaline intracellular pH (pHi). Chemoattractant bradykinin (BK) stimulated microglial migration by increasing lamellipodial area and protrusion rate, but reducing lamellipodial persistence time. Interestingly, blocking NHE-1 activity with its potent inhibitor HOE 642 not only acidified microglia, abolished the BK-triggered dynamic changes of lamellipodia, but also reduced microglial motility and microchemotaxis in response to BK. In addition, NHE-1 activation resulted in intracellular Na+ loading as well as intracellular Ca2+ elevation mediated by stimulating reverse mode operation of Na+/Ca2+ exchange (NCXrev). Taken together, our study shows that NHE-1 protein is abundantly expressed in microglial lamellipodia and maintains alkaline pHi in response to BK stimulation. In addition, NHE-1 and NCXrev play a concerted role in BK-induced microglial migration via Na+ and Ca2+ signaling. © 2013 Shi et al

Finding perfect polynomials mod 2

A number is said to be “perfect” if it equals the sum of its proper divisors. For example 6 is “perfect” because 6 = 1 + 2 + 3. On the other hand, a polynomial with integer coefficients modulo 2 is said to be “perfect” if the sum of its divisors equals the polynomial itself. In this presentation, we will highlight work that has been done to identify and classify all “perfect” polynomials

Dynamics of the chiral phase transition from AdS/CFT duality

We use Lorentzian signature AdS/CFT duality to study a first order phase transition in strongly coupled gauge theories which is akin to the chiral phase transition in QCD. We discuss the relation between the latent heat and the energy (suitably defined) of the component of a D-brane which lies behind the horizon at the critical temperature. A numerical simulation of a dynamical phase transition in an expanding, cooling Quark-Gluon plasma produced in a relativistic collision is carried out.Comment: 30 pages, 5 figure

Akciğer Kanseri Verileri ile İlgili Olarak Lojistik Regresyon Modellerinde Model Kurma

In this study, a simple and multiple logistic regression model forms, several of their key features and model building procedures are concerned. Maximum likelihood procedures are used to estimate the model parameters of a logistic model. Interpretation of the coefficients is explained by using odds ratio values. When the model includes more variables than needed, the greater estimated standard errors become. For this reason, there are some methods to find the best fitting through variables for the model. The final model equations of these methods can be different from each others. Here, the aim is to determine the “best” model. A logistic regression model is developed by using a database of 1200 patients with lung cancer in Izmir. In order to obtain a solution, univariate analysis, forward selection and backward elimination methods are applied to cancer data. The SPSS software package is used and results are evaluated.Bu çalışmada, basit ve çoklu lojistik regresyon model yapıları, onların bazı anahtar özellikleri ve model kurma yöntemleri ile ilgilenilmektedir. En çok olabilirlik yöntemleri lojistik modelin parametrelerini tahmin etmek için kullanılır. Katsayıların yorumu odds oran değerleri kullanılarak yapılmaktadır. Model gereğinden fazla değişken içerdiği zaman, daha büyük standart hatalar elde edilmektedir. Bu nedenle, değişkenler arasındaki en iyi modeli bulmak için bazı yöntemler kullanılmaktadır. Bu yöntemlerin son model denklemleri birbirinden farklılık gösterebilmektedir. Burada amaç “en iyi” modeli bulabilmektir. Çalışmada lojistik regresyon modeli, İzmir ilindeki akciğer kanserli 1200 hastaya ilişkin veriler kullanarak geliştirilmiştir. Çalışmada tek değişkenli lojistik regresyon çözümlemesi, ileriye doğru seçim ve geriye doğru eleme yöntemleri uygulanmıştır. Çözümlemeler SPSS paket programı kullanılarak yapılmış ve elde edilen sonuçlar tartışılmıştır

A quantum chemical study on structure of 1,2-bis(diphenylphosphinoyl)ethane and phenol cocrystal

WOS: 000225145100022The cocrystal of 1,2-bis(diphenylphosphinoyl)ethane (DPPEO) with phenol (1: 1) were studied theoretically with AM1, PM3, MNDO and MINDO/3 semi-empirical methods to elucidate its structure. The bond lengths and angles from theoretical studies of molecule DPPEO/phenol (1: 1) were found to be as expected. Theoretical results, concerning with intermolecular van der Waals forces in cocrystal, were compared with the previously obtained experimental data and AM1 results were found to be the best fit for bond lengths and angles of DPPEO/pheno

The Effect of Ventilation on the Accuracy of Pulmonary Artery and Wedge Pressure Measurements

journal articleBiomedical Informatic

A Note on Using Eigenvalues in Dimensionality Assessment

The dimensionality of a set of items is important for scale development. In practice, tools that make use of eigenvalues are often used to assess dimensionality. Parallel analysis is featured here as it is becoming an increasingly popular method for assessing the number of dimensions, and computational tools have recently been made available which will likely increase its use by practitioners. The current paper argues that methods that use eigenvalues to ascertain the number of factors may perform poorly under certain conditions, particularly for increasing levels of variable complexity and/or inter-factor correlations in the latent structure. A simulation study and an example are offered to substantiate this assertion. Accessed 2,400 times on https://pareonline.net from September 06, 2017 to December 31, 2019. For downloads from January 1, 2020 forward, please click on the PlumX Metrics link to the right

Molekularna serotipizacija sojeva bakterije Salmonella izoliranih iz pilećeg mesa za prodaju, na temelju in silico višestrukog PCR-a, određivanja ESBL-a i gena kolistin rezistencije mcr-1 do -5

Salmonella spp. are zoonotic pathogenic agents that cause important infections in humans and animals. They are the most common foodborne pathogens after Campylobacter spp. worldwide. The aim of this study was to determine the phenotypic and genotypic extended-spectrum β-lactamase (ESBL) and colistin resistance of 67 Salmonella spp. isolated from retail chicken meats between May and December 2016, and stored in the culture collection of Ataturk University, Faculty of Veterinary Medicine, Department of Microbiology. The isolates were serotyped using multiplex polymerase chain reaction (mPCR). The serovar distribution of strains was 74.6% S. Infantis, 16.4% S. Enteritidis, 3.0% S. Arizonae, 3.0% S. Dublin, 1.5% S. Gallinarum and 1.5% S. Indica. Of the 67 strains, 20 (29.9%) were ESBL- positive. The main types of β-lactamase identified were blaCTX-M-1, blaCTX-M-8-25, blaSHV and blaTEM. Four isolates were found to be phenotypically colistin-resistant. These isolates did not carry mobilised colistin resistance (mcr) genes 1 to 5. In this study, both genotypically ESBL-producing and phenotypically colistin-resistant Salmonella strains were found. We revealed that ESBL-producing Salmonella strains have dramatically increased over the years, especially when compared with previously reported chicken meat Salmonella strains in Turkey. The increase in Salmonella strains, particularly ESBL producers and the colistin resistant, is of great concern for selected antimicrobial therapy in human infections. Hence, epidemiological information and monitoring systems are extremely important in controlling Salmonella infections in public health services.Salmonella spp. zoonotski su patogeni koji uzrokuju infekcije u ljudi i životinja. Na globalnoj su razini najčešći patogeni koji se prenose hranom poslije bakterija Campylobacter spp. Cilj ovog istraživanja bio je fenotipski i genotipski odrediti β-laktamaze proširenog spektra (ESBL) i otpornost na kolistin 67 sojeva bakterija Salmonella spp. izoliranih iz pilećeg mesa za prodaju od svibnja do prosinca 2016. i pohranjenih u kulturama na Odsjeku za mikrobiologiju Fakulteta veterinarske medicine na Sveučilištu Ataturk. Izolati su serotipizirani primjenom višestruke lančane reakcije polimerazom (mPCR). Distribucija serovara bila je: 74,6 % za S. Infantis, 16,4 % za S. Enteritidis, 3,0 % za S. Arizonae, 3,0 % za S. Dublin, 1,5 % za S. Gallinarum i 1,5 % za S. Indica. Od 67 sojeva njih je 20 (29,9 %) bilo pozitivno na ESBL. Glavni identificirani tipovi β-laktamaza bili su: blaCTX-M-1, blaCTX-M-8-25, blaSHV i blaTEM. Četiri izolata bila su fenotipski otporna na kolistin. Ovi izolati nisu sadržavali aktivne gene rezistencije na kolistin (mcr) 1 do 5. U ovom su istraživanju nađeni i sojevi salmonele koji su genotipski proizvodili ESBL i sojevi fenotipski otporni na kolistin. Sojevi salmonele koji proizvode ESBL s godinama su se znatno povećali, posebno u usporedbi s prethodnim izvješćima o sojevima salmonele u mesu pilića u Turskoj. Porast sojeva salmonele, osobito onih koji proizvode ESBL i onih koji su otporni na kolistin, zabrinjava zbog antimikrobnog liječenja infekcija u ljudi. Zbog toga su u kontroli infekcija salmonelama u javnome zdravstvu iznimno važni epidemiološki podaci i sustavi praćenja

Morphometrische Analyse der retinalen Ganglienzellen in der menschlichen Netzhaut

Ziel dieser Studie war es, mit neuroanatomischen Verfahren der Fluoreszenzfärbung retinale Ganglienzellen retrograd anzufärben, um sie zu beschreiben und zu klassifizieren. Dies ist wichtig, weil GZ bei verschiedenen Erkrankungen mit einer Degeneration reagieren. Es wurden 1-2 Tage post mortem entnommene Retinae nach Anfärbung mit DiI für mehrere Monate bei Raumtemperatur aufbewahrt. Einzelne „komplett“ angefärbte GZ wurden fluoreszenzmikroskopisch aufgenommen. Eine Klassifizierung der GZ erfolgte aufgrund ihrer: Morphologie, Größe, Dendritenposition und -anzahl sowie Lokalisation. Die RGZ zeigten eine aufschlussreiche morphologische Vielfältigkeit. Die Midgetzellen und die Parasolzellen konnten u.a. identifiziert, unterklassifiziert und morphometrisch ausgewertet werden. Hiernach wurde festgestellt, dass diese Technik der Fluoreszenzfärbung allein nicht geeignet ist, aussagekräftige Rückschlüsse über degenerierte GZ infolge bestimmter Erkrankungen zu machen