La Storia della letteratura italiana come romanzo

La Storia della letteratura italiana di Francesco De Sanctis viene letta in questa relazione come un romanzo, forse il romanzo di maggior successo dell'Ottocento italiano, dopo I promessi sposi di Alessandro Manzoni. Nell'interpretazione di Ceserani la struttura del libro è basata su tre tipi molto popolari di narrazione praticati in quel secolo: 1) il romanzo storico, in cui realtà e invenzione sono mescolate e scene di movimento di grandi masse si alternano con scene in cui singoli grandi eroi (Dante, Machiavelli) sono celebrati e rappre­sentati nella loro monumentalità: 2) il romanzo di educazione o Bildungsroman, nel quale tuttavia il protagonista non è un singolo personaggio, che costruisce la sua individualità dalla giovinezza alla maturità, ma è, invece, un intero popolo, che passa attraverso fasi suc­cessive: una fase creativa e spontanea nel Trecento, una fase di decadenza nel Cinquecento e Seicento, una nuova partenza e un vero rinascimento nell'età moderna; 3) il dramma borghese e l'opera in musica, con il loro gusto per i contrasti dialettici e i forti conflitti.Francesco De Sanctis' History of Italian Literature is read in this paper as a novel, proba­bly the most successful novel of the Italian Nineteenth-Century after The betrothed by Alessandro Manzoni. According to Ceserani's interpretation, the structure of the book is based on three popular types of narrations written in that century: 1) the historical novel (or romance), in which reality and invention are combined and scenes of large masses alternate with scenes in which single great heroes (Dante, Machiavelli) are celebrated and represented in their monumentality; 2) the novel of education or Bildungsroman, but in this case the protagonist is not a single character, who constructs his individuality from youth to maturity; instead it is an entire people, who passes through different stages: a very creative and genuine one in the Trecento, an age of decadence during the Cinquecento and Seicento, a new start and a true renaissance in the modern times; 3) the bourgeois drama and the opera, with their penchant for dialectical contrasts and sharp conflicts

Un felice incontro

Il testo di Remo Ceserani dal titolo "Un felice incontro" fa parte di "Nel cuore della meraviglia" [Atti del convegno, marzo 2000] a cura di Isabelle Mallez e Raffaele Milani, "Quaderni di PsicoArt", n. 1, 2010

Literary History

ABSTRACT:  Recent changes in the theoretical and practical approaches to literary history: new interest in the relationship among literature, culture, and history, new attention to the narrative quality of this particular genre of history, new interpretations of the traditional problems: distinction between document and monument, distinction between the general and the individual. Some of the old approaches to writing literary history, such as the nineteenth-century examples of Geistesgeschichte or Stilgeschichte, have gone out of fashion. Newer suggestions have come from the French historians gathered around the journal Annales, the German school of Rezeptionskritik, and the American discussions on the canon. Among the types of literary history that are widely practiced today are those focused on the evolution of literary institutions, the development of a language, the history of ideas and ideologies, and the reconstruction of the biographical and sociological conditions underlying the production of a literary work. Two types of approaches seem to stand out: those that center on the development of literary forms and those that trace the changes in literary themes over time. The real achievement would be to provide, at the same time, a history of literary forms and a history of literary themes. KEYWORDS: Literature, culture, histor

Angiogenic and anti-inflammatory properties of micro-fragmented fat tissue and its derived mesenchymal stromal cells.

BACKGROUND: Adipose-derived mesenchymal stromal cells (Ad-MSCs) are a promising tool for advanced cell-based therapies. They are routinely obtained enzymatically from fat lipoaspirate (LP) as SVF, and may undergo prolonged ex vivo expansion, with significant senescence and decline in multipotency. Besides, these techniques have complex regulatory issues, thus incurring in the compelling requirements of GMP guidelines. Hence, availability of a minimally manipulated, autologous adipose tissue would have remarkable biomedical and clinical relevance. For this reason, a new device, named Lipogems® (LG), has been developed. This ready-to-use adipose tissue cell derivate has been shown to have in vivo efficacy upon transplantation for ischemic and inflammatory diseases. To broaden our knowledge, we here investigated the angiogenic and anti-inflammatory properties of LG and its derived MSC (LG-MSCs) population. METHODS: Human LG samples and their LG-MSCs were analyzed by immunohistochemistry for pericyte, endothelial and mesenchymal stromal cell marker expression. Angiogenesis was investigated testing the conditioned media (CM) of LG (LG-CM) and LG-MSCs (LG-MSCs-CM) on cultured endothelial cells (HUVECs), evaluating proliferation, cord formation, and the expression of the adhesion molecules (AM) VCAM-1 and ICAM-1. The macrophage cell line U937 was used to evaluate the anti-inflammatory properties, such as migration, adhesion on HUVECs, and release of RANTES and MCP-1. RESULTS: Our results indicate that LG contained a very high number of mesenchymal cells expressing NG2 and CD146 (both pericyte markers) together with an abundant microvascular endothelial cell (mEC) population. Substantially, both LG-CM and LG-MSC-CM increased cord formation, inhibited endothelial ICAM-1 and VCAM-1 expression following TNFα stimulation, and slightly improved HUVEC proliferation. The addition of LG-CM and LG-MSC-CM strongly inhibited U937 migration upon stimulation with the chemokine MCP-1, reduced their adhesion on HUVECs and significantly suppressed the release of RANTES and MCP-1. CONCLUSIONS: Our data indicate that LG micro-fragmented adipose tissue retains either per se, or in its embedded MSCs content, the capacity to induce vascular stabilization and to inhibit several macrophage functions involved in inflammation

Gemcitabine-releasing mesenchymal stromal cells inhibit in vitro proliferation of human pancreatic carcinoma cells

BACKGROUND AIMS: Pancreatic cancer (pCa) is a tumor characterized by a fibrotic state and associated with a poor prognosis. The observation that mesenchymal stromal cells (MSCs) migrate toward inflammatory micro-environments and engraft into tumor stroma after systemic administration suggested new therapeutic approaches with the use of engineered MSCs to deliver and produce anti-cancer molecules directly within the tumor. Previously, we demonstrated that without any genetic modifications, MSCs are able to deliver anti-cancer drugs. MSCs loaded with paclitaxel by exposure to high concentrations release the drug both in vitro and in vivo, inhibiting tumor proliferation. On the basis of these observations, we evaluated the ability of MSCs (from bone marrow and pancreas) to uptake and release gemcitabine (GCB), a drug widely used in pCa treatment. METHODS: MSCs were primed by 24-h exposure to 2000 ng/mL of GCB. The anti-tumor potential of primed MSCs was then investigated by in vitro anti-proliferation assays with the use of CFPAC-1, a pancreatic tumor cell line sensitive to GCB. The uptake/release ability was confirmed by means of high-performance liquid chromatography analysis. A cell-cycle study and secretome evaluation were also conducted to better understand the characteristics of primed MSCs. RESULTS: GCB-releasing MSCs inhibit the growth of a human pCa cell line in vitro. CONCLUSIONS: The use of MSCs as a "trojan horse" can open the way to a new pCa therapeutic approach; GCB-loaded MSCs that integrate into the tumor mass could deliver much higher concentrations of the drug in situ than can be achieved by intravenous injection

El ofrecimiento y la producción de prueba en la insolvencia trasnacional

El sistema probatorio internacional actual, siguiendo a Khun (1971), representa un paradigma erosionado, acabado, e imposible de resistir los embates del falsacionismo popperiano fuertemente impregnado del fenómeno global. La normativa de fuente interna -Código Civil y Comercial, Ley de Quiebras n° 24.522- así como los instrumentos normativos regionales del Mercosur (Protocolo de Las Leñas de 1992) establecen pautas relativas a la recepción u obtención de las pruebas y a su diligenciamiento, más nada establecen respecto al ofrecimiento y la producción de aquellas en el marco de la insolvencia internacional. Entendiendo que el rol de todo doctrinario es alumbrar a la legislación -fuente del derecho- y a los operadores del derecho, en general, proponemos este breve trabajo fruto de analizar y repensar la normativa actual a partir de la gran cantidad de casos fraudulentos y de insolvencia trasnacional que asolan no solo a nuestro país sino también a los fronterizos. En pos de ello proponemos en la norma el ofrecimiento y la producción de la prueba, en otras palabras, descorsetar el sistema probatorio internacional de los parámetros actuales en los cuales se halla inmerso. Creemos que ello permitirá lograr un margen importante de eficacia probatoria. Se requiere arbitrar los medios que permitan una verdadera internacionalización de la prueba, la celeridad y la premura que ella necesita. Sintetizando, el presente trabajo versará sobre el ofrecimiento y la producción probatoria en el marco de la insolvencia trasnacional. Al final se esbozará una conclusión de tendencia de “Lege Ferenda” a los fines de dejar plasmado el camino para un futuro cambio normativo.The current international probation system, following Khun (1971), represents a paradigm eroded, finished, and impossible to resist the onslaught of Popperian falsificationism strongly impregnated with the global phenomenon. The rules of internal source -Civil and Commercial Code, Bankruptcy Law No. 24,522- as well as the regional regulatory instruments of Mercosur (Las Lenas Protocol of 1992) establish guidelines regarding the receipt or obtaining of evidence and the completion of the same, but nothing established regarding the offer and production of those within the framework of international insolvency. Understanding that the role of any doctrinal is to enlighten the legislation -source of the law- and the operators of the law, in general, we propose this brief work as a result of analyzing and rethinking the current regulations based on the large number of fraudulent and insolvency cases transnational that ravage not only our country but also the borderlands. In pursuit of this, we propose in the norm the offer and production of the test, in other words, deconstructing the international evidence system of the current parameters in which it is immersed. We believe that this will allow us to achieve a significant margin of probative efficacy. It is necessary to arbitrate the means that allow a true internationalization of the test, the speed and the urgency that it needs. Synthesizing, this work will focus on offering and probative production in the framework of transnational insolvency. In the end, a trend conclusion of “Lege Ferenda” will be outlined in order to leave the way for a future regulatory change.O atual sistema internacional de liberdade condicional, seguindo Khun (1971), representa um paradigma erodido, acabado e impossível de resistir ao ataque do falsificacionismo popperiano fortemente impregnado pelo fenômeno global. As regras de fonte interna -Código Civil e Comercial, Lei de Falências nº 24.522-, bem como os instrumentos regulatórios regionais do Mercosul (Protocolo de Las Lenas de 1992) estabelecem diretrizes para o recebimento ou obtenção de provas e a conclusão do mesmo, mas nada estabelecido em relação à oferta e produção daqueles no âmbito da insolvência internacional. Entendendo que o papel de qualquer doutrina é esclarecer a legislação -fonte da lei- e os operadores da lei, em geral, propomos este breve trabalho como resultado da análise e repensação dos regulamentos atuais com base no grande número de casos fraudulentos e de insolvência transnacionais que devastam não apenas o nosso país, mas também as fronteiras. Em busca disso, propomos na norma a oferta e a produção do teste, ou seja, desconstruindo o sistema internacional de evidências dos parâmetros atuais em que ele está imerso. Acreditamos que isso nos permitirá alcançar uma margem significativa de eficácia probatória. É necessário arbitrar os meios que permitem uma verdadeira internacionalização do teste, a velocidade e a velocidade de que ele precisa. Em resumo, o presente trabalho focalizará a oferta e a produção probatória no âmbito da insolvência transnacional. No final, uma conclusão de tendência da “Lege Ferenda” será descrita a fim de deixar o caminho para uma futura mudança regulatória

Immigrazione, sicurezza e religione nel d.l. 130/2020 : Cauti ripristini, qualche innovazione e molta continuità

The paper analyzes the rules of the Legislative Decree 130/2020 directly and indirectly concerning the condition of migrants for religious reasons as well as the exercise of their rights of freedom, especially after the innovations on humanitarian protection in 2018. Other marginal aspects of the Legislative Decree and missed opportunities to ensure full protection of migrants’ religious affiliation are also considered

Davanti alla grande macchina della legge

Literature and its representations of the legal world.Remarkable differences between the administration of the  law in countries that follow the tradition of the Roman law and those that operate according to Anglo-Saxon customs. The protagonists of the court-room drama:  the defendant, the prosecutor, the lawyers, the testifiers, the expert witness, the judge, the jurors, the audience. The machine of the law, its functioning, the atmosphere of the court in their metaphorical representations in literary texts. The frequent difficulty experienced by defendants and audience to understand the machinery of the law. Examples from many literary and filmic texts, from the Book of Job to the novels by Grisham.La letteratura e le sue rappresentazioni del mondo della legge. Differenze profonde tra l’amministrazione della giustizia nei paesi eredi del diritto romano e quella nei paesi di tradizione anglosassone. I protagonisti della scena giudiziaria: l’imputato, il procuratore, gli avvocati, i testimoni, il perito di parte, il giudice, la giuria, il pubblico. La macchina della giustizia, i suoi funzionamenti, l’atmosfera delle udienze nelle metafore letterarie. La frequente incomprensione dei suoi meccanismi da parte di imputati e pubblico. Gli esempi di molti testi letterari e filmici, dal Libro di Giobbe ai romanzi di Grisham

Drug-releasing mesenchymal cells strongly suppress B16 lung metastasis in a syngeneic murine model

Mesenchymal stromal cells (MSCs) are considered an important therapeutic tool in cancer therapy. They possess intrinsic therapeutic potential and can also be in vitro manipulated and engineered to produce therapeutic molecules that can be delivered to the site of diseases, through their capacity to home pathological tissues. We have recently demonstrated that MSCs, upon in vitro priming with anti-cancer drug, become drug-releasing mesenchymal cells (Dr-MCs) able to strongly inhibit cancer cells growth