810 research outputs found

    Size-controlled conformal nanofabrication of biotemplated three-dimensional TiO2 and ZnO nanonetworks

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    Cataloged from PDF version of article.A solvent-free fabrication of TiO2 and ZnO nanonetworks is demonstrated by using supramolecular nanotemplates with high coating conformity, uniformity, and atomic scale size control. Deposition of TiO2 and ZnO on three-dimensional nanofibrous network template is accomplished. Ultrafine control over nanotube diameter allows robust and systematic evaluation of the electrochemical properties of TiO2 and ZnO nanonetworks in terms of size-function relationship. We observe hypsochromic shift in UV absorbance maxima correlated with decrease in wall thickness of the nanotubes. Photocatalytic activities of anatase TiO2 and hexagonal wurtzite ZnO nanonetworks are found to be dependent on both the wall thickness and total surface area per unit of mass. Wall thickness has effect on photoexcitation properties of both TiO2 and ZnO due to band gap energies and total surface area per unit of mass. The present work is a successful example that concentrates on nanofabrication of intact three-dimensional semiconductor nanonetworks with controlled band gap energies

    Eltrombopag for the treatment of immune thrombocytopenia: The aegean region of Turkey experience

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    Objective: Immune thrombocytopenia (ITP) is an immune-mediated disease characterized by transient or persistent decrease of the platelet count to less than 100x109/L. Although it is included in a benign disease group, bleeding complications may be mortal. With a better understanding of the pathophysiology of the disease, thrombopoietin receptor agonists, which came into use in recent years, seem to be an effective option in the treatment of resistant cases. This study aimed to retrospectively assess the efficacy, long-term safety, and tolerability of eltrombopag in Turkish patients with chronic ITP in the Aegean region of Turkey. Materials and Methods: Retrospective data of 40 patients with refractory ITP who were treated with eltrombopag in the Aegean region were examined and evaluated. Results: The total rate of response was 87%, and the median duration of response defined as the number of the platelets being over 50x109/L was 19.5 (interquartile range: 5-60) days. In one patient, venous sinus thrombosis was observed with no other additional risk factors due to or related to thrombosis. Another patient with complete response and irregular follow-up for 12 months was lost due to sudden death as the result of probable acute myocardial infarction. Conclusion: Although the responses to eltrombopag were satisfactory, patients need to be monitored closely for overshooting platelet counts as well as thromboembolic events. © 2015 Turkish Society of Hematology. All rights reserved

    Response of growing chicks to supplementation of low protein diets with leucine, valine and glycine-glutamic acid

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    This experiment was conducted to determine the interaction effects that resulted from supplementation of low-protein diets with leucine (Leu), valine (Val), and glycine-glutamic acid (Gly-Glu) on growing broiler chicks from 11 to 24 days old. Two levels of digestible Leu (1.07 and 1.50%) and three levels of digestible Val (0.64, 0.74, and 0.84%) were investigated as a 2 × 3 factorial arrangement of treatments with 12 replicates. The diet with 1.07% digestible Leu and 0.84% digestible Val was supplemented with 0.34% Gly and 1.32% Glu as an additional treatment (T7). At 24 days old, 0.84% Val significantly improved feed conversion with 1.07% Leu, but 0.74% Val was sufficient with 1.50% Leu. The T7 diet further improved feed conversion. Increasing dietary Val from 0.64% to 0.74% significantly increased bone density and strength at the lower level of dietary Leu, while T7 significantly increased tibia breaking strength. There were significant Leu × Val interactions for villus height, crypt depth, and goblet cell numbers. Val at 0.84% maximized the development of the jejunum at the lower Leu level, while goblet cell number and crypt depth were impaired by increments of Val at the higher level of Leu. In conclusion, increasing the level of Val in low-protein grower diets significantly improved performance, bone and jejunum development of broilers, and its interaction with Leu was important. Therefore, these two amino acids (AAs) and the possibility of Gly-Glu fortification must be considered when formulating low-protein broiler diets. Keywords: bone traits, branched-chain amino acids, broilers, gut histology, performanc

    Query Answer Explanations under Existential Rules

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    Ontology-mediated query answering is an extensively studied paradigm, which aims at improving query answers with the use of a logical theory. In this paper, we focus on ontology languages based on existential rules, and we carry out a thorough complexity analysis of the problem of explaining query answers in terms of minimal subsets of database facts and related task

    Recent advances in querying probabilistic knowledge bases

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    We give a survey on recent advances at the forefront of research on probabilistic knowledge bases for representing and querying large-scale automatically extracted data. We concentrate especially on increasing the semantic expressivity of formalisms for representing and querying probabilistic knowledge (i) by giving up the closed-world assumption, (ii) by allowing for commonsense knowledge (and in parallel giving up the tuple-independence assumption), and (iii) by giving up the closed-domain assumption, while preserving some computational properties of query answering in such formalisms

    Draft Genome Sequence of the Marine Streptomyces sp. Strain PP-C42, Isolated from the Baltic Sea

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    Streptomyces, a branch of aerobic Gram-positive bacteria represents the largest genus of actinobacteria. The streptomycetes are characterized by a complex secondary metabolism and produce over two-thirds of the clinically used natural antibiotics today. Here we report the draft genome sequence of a Streptomyces strain PP-C42 isolated from the marine environment. A subset of unique genes and gene clusters for diverse secondary metabolites as well as antimicrobial peptides (AMPs) could be identified from the genome, showing great promise as a source for novel bioactive compound

    Effects of Lower Dietary Calcium and Phosphorus on Growth Performance and Bone Mineralizatıon of Broilers

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    This experiment was carried out to investigate the effects of reduced dietary calcium (Ca) and non-phytate-phosphorus (NPP) levels at 2:1 constant ratio on performance, carcase parameters and bone mineralization of Ross-308 broilers. A total of 11400 one-day-old chicks were randomly allocated to five dietary treatments with twelve replicates and were fed starter diets including either recommended (control treatment, T1) or a 6.25% lower level of both Ca and NPP according to breeder’s recommendations during starter period (SP). After SP, control treatment (T1) continued to be provided through diets containing 0.87 and 0.78 % Ca for grower (GP) and finisher periods (FP), respectively, while 6.25 % reduced group was divided into 4 dietary treatments regarding extent of decrease in Ca and NPP levels and provided by diets containing 0.79;0.65 (T2), 0.79;0.60 (T3), 0.75;0.65 (T4), and 0.75;0.60 (T5) % Ca for GP and FP, respectively. After SP, moderate and even substantial reduction of Ca and NPP significantly decreased feed intake (FI) (quadratic, P<0.05), but obtained similar body weight gain (BWG) and FCR compared to the control (P>0.05). On the other hand, reduced dietary Ca through T1 to T5 significantly decreased the total Ca and NPP intake of broilers (linear and quadratic, P<0.01), and accompanied to significant linear and quadratic relationship between Ca intake and FCR and BWG respectively. It can be concluded that reducing Ca level down to 0.75 and 0.60 % in grower and finisher phase, respectively are possible without compromising the growth performance and bone mineralization of modern broilers

    Draft Genome Sequence of the Marine Streptomyces sp. Strain PP-C42, Isolated from the Baltic Sea

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    Streptomyces, a branch of aerobic Gram-positive bacteria represents the largest genus of actinobacteria. The streptomycetes are characterized by a complex secondary metabolism and produce over two-thirds of the clinically used natural antibiotics today. Here we report the draft genome sequence of a Streptomyces strain PP-C42 isolated from the marine environment. A subset of unique genes and gene clusters for diverse secondary metabolites as well as antimicrobial peptides (AMPs) could be identified from the genome, showing great promise as a source for novel bioactive compound

    Synthesis of Multi-substituted 4,5-Dihydrofuran Derivatives from (S)-Limonene and 1,3-Dicarbonyl Compounds and their Biological Activities

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    Multi-substituted 4,5-dihydrofuran derivatives were regioselectively synthesized by the reaction of α-carbo radical produced from 1,3-dicarbonyl compounds by oxidation with Mn(OAc)3 in Acetic acid and S-(-)-limonene. All the compounds were tested for their antibacterial and antifungal activities by the disc-diffusion technique
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