Effects of a smart phone-based game on balance ability and dizziness in healthy adult individuals

Many people use smartphone these days. There are many studies on the effects of smartphones on our bodies, but there is a lack of research on balance and dizziness. The purpose of this study was to determine how a healthy person’s balance and dizziness is affected by using smart devices. Twenty four healthy adults in their twenties were assigned to the 10-minute and 20-minute group based on the duration of the smartphone game. To evaluate the effects of smartphone games on the balance and dizziness of the participants, we evaluated their balance and dizziness before and after playing the smartphone game. Balance was measured using a force plate (Wii Balance Board, Balancia version 2.0, Mintosys Inc., Seoul, KR) and dizziness was measured using the Simulator sickness Questionnaire (SSQ). There was a significant difference in balance among both groups before and after playing the smartphone game (p .05). Regarding dizziness, the SSQ score indicated minimal symptoms in the 10-minute group, while it revealed significant symptoms in the 20-minute group. In this study, playing a smartphone game for 10 minutes and 20 minutes was found to affect balance. Further, it was found that playing a smartphone game for 20 minutes may lead to a significant level of dizziness

Evaluation of clopidogrel impact on canine platelet function using flow cytometry and thromboelastography platelet mapping

BackgroundClopidogrel is frequently used in veterinary medicine to therapeutically decrease platelet function, although some different dosages have been published. Therefore, we assessed the antiplatelet effects of the recommended dosage (1 mg/kg PO q24h) on canine platelet function.MethodsFive dogs were administered either clopidogrel or placebo, with a 14-day washout period. Platelet function was assessed using thromboelastography (TEG) and flow cytometry, complete blood count, and biochemical analyses were performed for clinicopathological evaluation. Blood samples were collected at baseline and 7 days after drug administration. TEG parameters including maximum amplitude and platelet mapping for adenosine diphosphate (ADP)-induced responses were used to monitor therapeutic efficacy. Flow cytometry was used to analyze CD62P expression and platelet activation stimulated by ADP and other agonists.ResultsTEG analysis demonstrated a significant reduction in ADP-induced clot strength following clopidogrel administration (p < 0.05), indicating effective platelet inhibition. Flow cytometry confirmed the marked inhibition of platelet activation, with significant decreases in the percentage of CD62P positive platelets and the mean fluorescence intensity under ADP and epinephrine stimulation (p < 0.05). Hematological and biochemical parameters remained stable across all groups, confirming the safety of clopidogrel administration. These findings highlight the efficacy and safety of clopidogrel as an antiplatelet agent in dogs.ConclusionThis study confirmed the efficacy of low-dose (1 mg/kg, p.o., q24h) clopidogrel in dogs without a loading dose. TEG and flow cytometry are effective tools for assessing clopidogrel responsiveness in dogs and may aid in optimizing antiplatelet therapy in clinical practice

Fluorescent and Catalytic Properties of a 2D Lamellar Zn Metal–Organic Framework with sql Network Structure

A two-dimensional (2D) lamellar Zn metal–organic framework (Zn-MOF, 1) with a fluorescent 1,6-di(pyridin-3-yl)pyrene (3-DPPy) and 1,4-benzenedicarboxylate (BDC2−) bridging linkers was prepared and structurally characterized. The chemical formula of 1 is [Zn(μ-3-DPPy)(μ-BDC)]n. The mononuclear Zn(II) ion, acting as a node, is tetrahedrally coordinated with two 3-DPPy and two BDC linkers. The coordination environment of Zn(II) is a distorted tetrahedral geometry. The Zn-MOF is the sql network structure based on topology analysis. The undulated 2D sheets of 1 tightly pack together to form a lamellar structure. The pyrene moieties are parallelly oriented to each other. The Zn-MOF is not porous, possibly because the mononuclear Zn(II) node did not form cluster-based secondary building units due to the less symmetric 3-DPPy. The steady-state fluorescence measurements indicate that the fluorescence signal of the 1 is slightly blue-shifted compared to the free 3-DPPy in the solid state. The excimer emission band at 463 nm for crystalline 3-DPPy is shifted to 447 nm for 1. The value of 447 nm is also a blue-shift value compared to nonsubstituted pyrene crystals (470 nm). Despite its nonporosity, the surface Lewis acidic sites of 1 could catalyze the transesterification of esters. Surface defect sites are responsible for this catalytic activity

WasDom: An Efficient Write Protection for Wasm JITed Code With ARM Domain

WebAssembly (Wasm) is a binary instruction format designed to run web applications efficiently and securely across different browsers, including Chrome’s V8, Firefox’s SpiderMonkey, and Safari’s JavaScriptCore. While Wasm’s Just-In-Time (JIT) compilation offers significant performance benefits by converting wasm code into machine code (JITed code), it introduces security vulnerabilities by violating the W^X (Write XOR Execute) policy. Conventional methodologies, such as Intel MPK for safeguarding JITed code, are constrained to specific hardware and are ineffectual in mobile environments. Consequently, there is a necessity for the development of a ARM-compatible solution. This paper proposes WasDom, an efficacious write protection mechanism for wasm JITed code on ARM architecture. Leveraging ARM’s domain-based memory management, WasDom employs a randomized domain allocation strategy to permit multiple cores to access JITed code securely. The prototype of WasDom was implemented in the V8 runtime and demonstrated a minimal performance overhead of less than 11% while providing strong write protection. The system manages memory permissions dynamically through the Domain Access Control Register (DACR), ensuring that memory regions are writable during JIT compilation and executable during runtime, thus enforcing a strong W^X policy

Effect of Ti Content on the Microstructure and High-Temperature Creep Property of Cast Fe-Ni-Based Alloys with High-Al Content

The cast Fe-Ni-based austenitic heat-resistant alloys with 4.5 wt% Al and varying Ti content were developed for high-temperature application. With increase in Ti content, strength of model alloys increased gradually at 700 °C and 750 °C. At 750 °C, alloys with 35Ni–(2~4)Ti composition showed a significant increase in creep rupture life compared to 30Ni–1Ti alloy, attributed to the increase in γ’-Ni3(Al,Ti) precipitates due to higher Ni and Ti content. Among the 35Ni–(2~4)Ti alloys, increasing Ti content from 2 to 4 wt% gradually increased the creep rupture life in the as-cast condition. The creep rupture life was improved after solution annealing treatment, however, the beneficial effect of higher Ti content was not evident for 35Ni–(2~4)Ti alloys. After solution annealing, interdendritic phases were partially dissolved, but coarse B2-NiAl phases were formed. The size and amount of coarse B2-NiAl phases increased with Ti content. In the creep-tested specimens, creep void nucleation and crack propagation were observed along the coarse B2-NiAl phases, especially for high-Ti alloys. Therefore, the beneficial effect of the increase in γ’-Ni3(Al,Ti) precipitates for high-Ti alloys on creep property was limited due to the detrimental effect of the presence of coarse B2-NiAl phases.</jats:p