Enterprise Architecture Planning using the TOGAF 9.2 Framework at the Department of Tourism, Youth, and Sports of Tasikmalaya Regency.

The Tourism, Youth, and Sports Agency (DISPARPORA) of Tasikmalaya Regency is tasked with supporting the Regent in managing government functions related to tourism, youth, and sports (Tasikmalaya Regency Regent Regulation No. 36, 2016). The utilization of systems and technology in DISPARPORA Tasikmalaya Regency is currently not optimal and not fully aligned with its business process needs. At present, several applications such as SIMPEG, SIMDA, and SADASBOR are being used. However, some other data management processes, such as archiving incoming and outgoing letters and managing official travel, are still handled manually using notebooks and Microsoft Office applications. This poses risks of human error and data redundancy, which could hinder data management and the agency's task execution. As a follow-up to these issues, architecture enterprise planning is needed at DISPARPORA Tasikmalaya Regency to improve agency performance and provide better services to the community by leveraging SI/TI. The architecture enterprise . planning will be developed using the TOGAF ADM 9.2 framework, following several stages such as the phase preliminary, phase architecture vision, phase architecture business, phase information systems architecture, phase  architecture technology, and the opportunities and solutions phase. The results of this study include a blueprint consisting of 7 architectures business, 3 architectures information systems, and 1 architecture  technology. . Additionally, this study produces a roadmap for implementing the architecture enterprise planning

IDENTIFIKASI KENDALA PENGELOLAAN KAWASAN AGROPOLITAN KABUPATEN CIANJUR

Urbanisasi merupakan salah satu permasalahan utama di Indonesia. Laju urbanisasi di Indonesia naik 3,3% setiap tahun dan angka ini merupakan laju urbanisasi tercepat se-Asia. Urbanisasi akan memberikan pengaruh positif dan negatif. Salah satu dampak negatif yang ditimbulkan oleh urbanisasi adalah kurangnya regenerasi petani karena urbanisasi dan migrasi merupakan salah satu alasan terjadi kurangnya regenerasi petani khususnya di wilayah pedesaan. Program agropolitan merupakan salah satu solusi yang dilakukan pemerintah untuk menekan angka urbanisasi tersebut sejak tahun 2002. Kawasan Agropolitan Kabupaten Cianjur merupakan salah satu kawasan agropolitan yang pertama kali dibentuk pada tahun 2002. Seteah berjalan 16 tahun, kawasan agropolitan ini tidak berkembang secara signifikan. Tujuan dari penelitian ini adalah untuk mengidentifikasi kendala pengelolaan Kawasan Agropolitan Kabupaten Cianjur agar para stakeholder bisa menemukan solusi dari kendala tersebut. Identifikasi kendala pengelolaan menggunakan metode analisis deskriptif. Data didapatkan dari hasil wawancara dengan stakeholder kawasan agropolitan. Kendala yang dihadapi yaitu benih komoditas tertentu terkadang sulit didapatkan, gangguan hama penyakit dan pencurian, penggunaan bahan kimia yang masih tinggi,  kurangnya pengetahuan petani akan pengolahaan produk yang tidak sesuai permintaan (reject), fasilitas packing house yang terlalu jauh, pasar produk olahan yang sedikit, kurangnya pertemuan antar stakeholder kawasan agropolitan, petani belum mengerti sistem kawasan agropolitan, kurangnya monitoring dan evaluasi dari pemerintah, sarana dan prasarana yang rusa

Fish remains (Elasmobranchii, Actinopterygii) from the Late Cretaceous of the Benue Trough, Nigeria

International audienceSelachian and ray-finned fish remains from various Late Cretaceous localities of Nigeria are described. Each locality has yielded only a very few specimens and the diversity is therefore very low. However, some taxa are recorded for the first time in Africa. The Ashaka locality in the Upper Benue Trough (northeastern Nigeria) has yielded a small but interesting late Cenomanian assemblage of microremains, including teeth of ''Carcharias'' amonensis, Rhombopterygia zaborskii sp. nov., Hamrabatis sp., ''Stephanodus'' sp., and a possible ionoscopiform. A large prearticular dentition coming from the early Turonian beds of this locality is assigned to the large pycnodontiform Acrotemnus, a poorly known genus here regarded as a senior synonym of Macropycnodon. In the Lower Benue Trough (southeastern Nigeria), several localities ranging in age from the late Cenomanian to the early Maastrichtian have yielded various widespread taxa such as Ptychodus, Scapanorhynchus, Squalicorax, Vidalamiinae indet., cf. Protosphyraena, and Eodiaphyodus. The seaway that occupied the Benue Trough during transgressive episodes (late Cenomanian-early Turonian and Maastrichtian) created opportunities for the dispersal of many marine fish taxa into new areas, such as the proto-South Atlantic

Pollution-Affected Fish Hepatic Transcriptome and Its Expression Patterns on Exposure to Cadmium

Individuals of the fish Lithognathus mormyrus were exposed to a series of pollutants including: benzo[a]pyrene, pp-DDE, Aroclor 1254, perfluorooctanoic acid, tributyl-tin chloride, lindane, estradiol, 4-nonylphenol, methyl mercury chloride, and cadmium chloride. Five mixtures of the pollutants were injected. Each mixture included one to three compounds. A microarray was constructed using 4608 L. mormyrus hepatic cDNAs cloned from the pollutant-exposed fish. Most clones (4456) were sequenced and assembled into 1494 annotated unique clones. The constructed microarray was used to identify changes in hepatic gene expression profile on exposure to cadmium administered to the fish by feeding or injections. Thirty-one unique clones showed altered expression levels on exposure to cadmium. Prominently differentially expressed genes included elastase 4, carboxypeptidase B, trypsinogen, perforin, complement C31, cytochrome P450 2K5, ceruloplasmin, carboxyl ester lipase, and metallothionein. Twelve sequences have no available annotation. Most genes (23) were downregulated and hypothesized to be affected by general toxicity due to the intensive cadmium exposure regime. The concept of an operational multigene cDNA microarray, aimed at routine and fast biomonitoring of multiple environmental threats, is outlined and the cadmium exposure experiment has been used to demonstrate functional and methodological aspects of the biomonitoring tool. The components of the outlined system include: (1) spotted array, composed of both pollution-affected and constitutively expressed genes, the latter are used for normalization; (2) standard, repeatable labeling procedure of a reference transcript population; and (3) biomarker indices derived from the profile of expression ratio across the pollution-affected genes, between the field-sampled transcript populations and the reference

PERANCANGAN SISTEM INFORMASI REKAM MEDIS BERBASIS WEBSITE (Studi Kasus: Klinik Gigi Pondok Dental Care Sukoharjo)

Manual data collection at the Pondok Dental Care Sukoharjo Clinic has many limitations that lead to inefficiency in processing the required information. Information obtained from field studies states that there is no information system related to clinical documents, such as patient information, patient complaints, and medical history, which requires the establishment of a patient record information system, so that errors often occur in data collection which can hinder the search for information by staff. medical. This study aims to create an information system that can be used in patient care at the Pondok Dental Care Sukoharjo Clinic. Medical record information systems can be a solution to several problems such as helping to improve the accuracy and thoroughness of patient data, facilitating the recording process, and searching for the history of treatment data that has been given to patients. This research produced a medical record information system at the Pondok Dental Care Sukoharjo Clinic using the Laravel Framework, and Blackbox Testing as system testing. From this test, valid results were obtained, which means that the medical record information system for the Pondok Dental Care Sukoharjo Dental Clinic can run well

Protandric Transcriptomes to Uncover Parts of the Crustacean Sex-Differentiation Puzzle

Hermaphrodite systems offer unique opportunities to study sexual differentiation, due to their high degree of sexual plasticity and to the fact that, unlike gonochoristic systems, the process is not confined to an early developmental stage. In protandric shrimp species, such as Hippolyte inermis and Pandalus platyceros, male differentiation is followed by transformation to femaleness during adulthood. The mechanisms controlling sexual differentiation have not been fully elucidated in crustaceans, but a key role has been attributed to the insulin-like hormone (IAG) produced by the androgenic gland (AG), a crustacean masculine endocrine organ. To uncover further transcriptomic toolkit elements affecting the sexual differentiation of H. inermis, we constructed eye and whole body RNA libraries of four representative stages during its protandric life cycle (immature, male, young female and mature female). The body libraries contained transcripts related to the reproductive system, among others, while the eye libraries contained transcripts related to the X-organ-sinus gland, a central endocrine complex that regulates crustacean reproduction. Binary pattern analysis, performed to mine for genes expressed differentially between the different life stages, yielded 19,605 and 6,175 transcripts with a specific expression pattern in the eye and body, respectively. Prominent sexually biased transcriptomic patterns were recorded for the IAG and vitellogenin genes, representing, respectively, a key factor within the masculine IAG-switch, and a precursor of the yolk protein, typical of feminine reproductive states. These patterns enabled the discovery of novel putative protein-coding transcripts exhibiting sexually biased expression in the H. inermis body and eye transcriptomes of males and females. Homologs to the above novel genes have been found in other decapod crustaceans, and a comparative study, using previously constructed transcriptomic libraries of another protandric shrimp, P. platyceros, showed similar sexually biased results, supporting the notion that such genes, mined from the H. inermis transcriptome, may be universal factors related to reproduction and sexual differentiation and their control in other crustaceans. This study thus demonstrates the potential of transcriptomic studies in protandric species to uncover unexplored layers of the complex crustacean sex-differentiation puzzle

PLANdbAffy: probe-level annotation database for Affymetrix expression microarrays

Standard Affymetrix technology evaluates gene expression by measuring the intensity of mRNA hybridization with a panel of the 25-mer oligonucleotide probes, and summarizing the probe signal intensities by a robust average method. However, in many cases, signal intensity of the probe does not correlate with gene expression. This could be due to the hybridization of the probe to a transcript of another gene, mapping of the probe to an intron, alternative splicing, single nucleotide polymorphisms and other reasons. We have developed a database, PLANdbAffy (available at http://affymetrix2.bioinf.fbb.msu.ru), that contains the results of the alignment of probe sequences from five Affymetrix expression microarrays to the human genome. We have determined the probes matching the transcript-coding regions in the correct orientation. For each such probe alignment region, we determined the mRNA and EST sequences that contain the probe sequence. In the textual part of the database interface we summarize the data on the sequences that cover the probe alignment region and SNPs that are located inside it. The graphical part of our database interface is implemented as custom tracks to the UCSC genome browser that allows one to utilize all the data that are offered by UCSC browser