Gender-specific differences of bronchial asthma phenotypes in children depending on puberty status

Further investigations are needed to examine the effect of gender-specific differences in changes of asthma prevalence and phenotypes in pre- and post puberty. Objective of the study was to evaluate if sex-based differences exist in clinical and epidemiologic characteristics of asthma in children before and after puberty

A Planning Pipeline for Large Multi-Agent Missions

In complex multi-agent applications, human operators are often tasked with planning and managing large heterogeneous teams of humans and autonomous vehicles. Although the use of these autonomous vehicles broadens the scope of meaningful applications, many of their systems remain unintuitive and difficult to master for human operators whose expertise lies in the application domain and not at the platform level. Current research focuses on the development of individual capabilities necessary to plan multi-agent missions of this scope, placing little emphasis on the integration of these components in to a full pipeline. The work presented in this paper presents a complete and user-agnostic planning pipeline for large multiagent missions known as the HOLII GRAILLE. The system takes a holistic approach to mission planning by integrating capabilities in human machine interaction, flight path generation, and validation and verification. Components modules of the pipeline are explored on an individual level, as well as their integration into a whole system. Lastly, implications for future mission planning are discussed

The use of nanotechnology in cardiovascular disease

Cardiovascular diseases claim a number of lives globally; many of which are preventable. With the increase in diets that consist of high saturated fat, salt, and sugar, people often living sedentary lifestyles, and a rise in cases of obesity, the incidence of cardiovascular disease is increasing. These contributing factors, coupled with more advanced methods of diagnosis, have delivered statistics that clearly show that there is a rising trend in the prevalence of cardiovascular disease. Treatment for cardiovascular diseases is limited currently to oral medicines or invasive surgery. There is a huge gap in this area of medicine for novel therapeutics for improved patient outcomes. Nanotechnology may provide a solution to more effective treatment of disease, with better prognoses and a reduced side effect profile. This review will explore for potential solutions to the limited pharmacological therapies currently on the market and the future that lies ahead for the place of nanotechnology within cardiovascular medicine

Multi-Operator Gesture Control of Robotic Swarms Using Wearable Devices

The theory and design of effective interfaces for human interaction with multi-robot systems has recently gained significant interest. Robotic swarms are multi-robot systems where local interactions between robots and neighbors within their spatial neighborhood generate emergent collective behaviors. Most prior work has studied interfaces for human interaction with remote swarms, but swarms also have great potential in applications working alongside humans, motivating the need for interfaces for local interaction. Given the collective nature of swarms, human interaction may occur at many levels of abstraction ranging from swarm behavior selection to teleoperation. Wearable gesture control is an intuitive interaction modality that can meet this requirement while keeping operator hands usually unencumbered. In this paper, we present an interaction method using a gesture-based wearable device with a limited number of gestures for robust control of a complex system: a robotic swarm. Experiments conducted with a real robot swarm compare performance in single and two-operator conditions illustrating the effectiveness of the method. Results show human operators using our interaction method are able to successfully complete the task in all trials, illustrating the effectiveness of the method, with better performance in the two-operator condition, indicating separation of function is beneficial for our method. The primary contribution of our work is the development and demonstration of interaction methods that allow robust control of a difficult to understand multi robot system using only the noisy inputs typical of smartphones and other on-body sensor driven devices

Hierarchical Cluster Analysis to Aid Diagnostic Image Data Visualization of MS and Other Medical Imaging Modalities

Perceiving abnormal regions in the images of different medical modalities plays a crucial role in diagnosis and subsequent treatment planning. In medical images to visually perceive abnormalities’ extent and boundaries requires substantial experience. Consequently, manually drawn region of interest (ROI) to outline boundaries of abnormalities suffers from limitations of human perception leading to inter-observer variability. As an alternative to human drawn ROI, it is proposed the use of a computer-based segmenta- tion algorithm to segment digital medical image data. Hierarchical Clustering-based Segmentation (HCS) process is a generic unsupervised segmentation process that can be used to segment dissimilar regions in digital images. HCS process generates a hierarchy of segmented images by partitioning an image into its constituent regions at hierarchical levels of allowable dissimilarity between its different regions. The hierarchy represents the continuous merging of similar, spatially adjacent, and/or disjoint regions as the allowable threshold value of dissimilarity between regions, for merging, is gradually increased. This chapter discusses in detail first the implementation of the HCS process, second the implementa- tion details of how the HCS process is used for the presentation of multi-modal imaging data (MALDI and MRI) of a biological sample, third the implementation details of how the process is used as a perception aid for X-ray mammogram readers, and finally the implementation details of how it is used as an interpreta- tion aid for the interpretation of Multi-parametric Magnetic Resonance Imaging (mpMRI) of the Prostate

Differential Pre-mRNA Splicing Regulates Nnat Isoforms in the Hypothalamus after Gastric Bypass Surgery in Mice

Background Neuronatin (NNAT) is an endoplasmic reticulum proteolipid implicated in intracellular signalling. Nnat is highly-expressed in the hypothalamus, where it is acutely regulated by nutrients and leptin. Nnat pre-mRNA is differentially spliced to create Nnat-α and -β isoforms. Genetic variation of NNAT is associated with severe obesity. Currently, little is known about the long-term regulation of Nnat. Methods Expression of Nnat isoforms were examined in the hypothalamus of mice in response to acute fast/feed, chronic caloric restriction, diet-induced obesity and modified gastric bypass surgery. Nnat expression was assessed in the central nervous system and gastrointestinal tissues. RTqPCR was used to determine isoform-specific expression of Nnat mRNA. Results Hypothalamic expression of both Nnat isoforms was comparably decreased by overnight and 24-h fasting. Nnat expression was unaltered in diet-induced obesity, or subsequent switch to a calorie restricted diet. Nnat isoforms showed differential expression in the hypothalamus but not brainstem after bypass surgery. Hypothalamic Nnat-β expression was significantly reduced after bypass compared with sham surgery (P = 0.003), and was positively correlated with post-operative weight-loss (R2 = 0.38, P = 0.01). In contrast, Nnat-α expression was not suppressed after bypass surgery (P = 0.19), and expression did not correlate with reduction in weight after surgery (R2 = 0.06, P = 0.34). Hypothalamic expression of Nnat-β correlated weakly with circulating leptin, but neither isoform correlated with fasting gut hormone levels post- surgery. Nnat expression was detected in brainstem, brown-adipose tissue, stomach and small intestine. Conclusions Nnat expression in hypothalamus is regulated by short-term nutrient availability, but unaltered by diet-induced obesity or calorie restriction. While Nnat isoforms in the hypothalamus are co-ordinately regulated by acute nutrient supply, after modified gastric bypass surgery Nnat isoforms show differential expression. These results raise the possibility that in the radically altered nutrient and hormonal milieu created by bypass surgery, resultant differential splicing of Nnat pre-mRNA may contribute to weight-loss

Performance Evaluation of Life Insurance Corporation of India

Human life is a full of risk. The effective solution of reducing the burden of these risks / losses is insurance. Insurance occupies an important position in the financial sector of an economy. In a period of less than half a century the insurance sector in a country has come in a full circle from being an open competitive market to compete nationalisation and then back to a liberalised market. The entry of private player’s in the Indian insurance market has change the nature of competition. But LIC (Life Insurance Corporation of India) continuous to be the dominant life insurer even in the liberalised scenario of Indian insurance and it moving fact on a new growth trajectory surpassing its own past records. Insurance Regulatory and Development Authority (IRDA) has been established to protect the interests of holders of insurance policy and to regulate, promote and insure growth of the insurance industry. The present research work is an attempt to study the performance of LIC after liberalization policy regime. The aim of this study is to evaluate the financial & business performance of LIC for ten years from 1996-97 to 2005-06. This study has been divided into five chapters. The first chapter is introductory in nature and explains overview of the insurance sector. The second chapter focuses on the research methodology of the study. The third chapter evaluates the financial performance of LIC. The fourth chapter analyses the business performance of LIC. While sixth chapter shows summary, findings, conclusions and suggestions for present research study

A Safe Cooperative Framework for Atmospheric Science Missions with Multiple Heterogeneous UAS using Piecewise Bezier Curves

Autonomous operation of UAS holds promise for greater productivity of atmospheric science missions. However, several challenges need to be overcome before such missions can be made autonomous. This paper presents a framework for safe autonomous operations of multiple vehicles, particularly suited for atmospheric science missions. The framework revolves around the use of piecewise Bezier curves for trajectory representation, which in conjunction with path-following and time-coordination algorithms, allows for safe coordinated operations of multiple vehicles