SISTEM INFORMASI MANAJEMEN KEPEGAWAIAN PADA PT. CAHAYAMULIA GLASSINDO LESTARI BERBASIS WEBSITE

Tujuan dari perancangan sistem informasi ini adalah membangun sistem kepegawaian pada PT. Cahayamulia Glassindo Lestari untuk mengatasi permasalahan pengambilan data absensi, rumitnya perekrutan pegawai, dan pengelolaan data pegawai yang tidak teratur. Metodologi yang digunakan dalam pengembangan sistem informasi ini adalah RUP (Rational Unified Procces), dengan tahapan inception (permulaan), elaboration (perluasan/perencanaan), construction (konstruksi), dan transition (transisi). Hasil dari pengembangan sistem ini adalah sistem kepegawaian yang dapat membantu mengelola data kepegawaian secara teratur dan terintegrasi. Pengembangan system ini dilakukan dengan menggunakan Notepad++ sebagai editor, PHP untuk bahasa pemrograman dan MySQL sebagai basis datanya. Sistem yang akan dibangun ini diharapkan dapat mengatasi permasalahan kepegawaian yang ada pada PT Cahayamulia Glassindo Lestari Palembang. Kata kunci— Sistem Informasi,Website, Kepegawaian, RUP, PH

PENGEMBANGAN GAIT MOBILE ROBOT TIPE HEXAPOD UNTUK MELEWATI RINTANGAN

PENGEMBANGAN GAIT MOBILE ROBOT TIPE HEXAPOD UNTUK MELEWATI RINTANGAN - Robot,hexapod, pengembangan gait, rintangan, gait, mobile robot, robot berkaki, servo motor, SSC-32

Perancangan Cergam Interaktif Dengan Tema Bullying Untuk Anak Umur 10-12 Tahun

Kasus bullying semakin marak terjadi terutama di lingkungan sekolah, namun ternyata masih banyak orang yang belum benar-benar mengerti apa itu bullying dan dampak-dampak yang ditimbulkannya. Dampak-dampak negatif yang disebabkan bullying bukan hanya pada korban tapi juga pada tapi juga pada pelaku, antara lain tidak percaya diri, depresi, gelisah dan kecenderungan bersifat agresif. Bullying yang terjadi pada anak dapat memberikan luka psikologis yang dibawa sampai seumur hidup. Perancangan ini dibuat dengan tujuan agar anak usia 10-12 tahun menyadari akan bullying yang terjadi dan dampak-dampak yang ditimbulkannya. Dengan begitu diharapkan dapat menciptakan generasi yang lebih baik dengan kehidupan sosial yang lebih sehat

Correction to: Stories of loss and healing: connecting non-economic loss and damage, gender-based violence and wellbeing erosion in the Asia–Pacific region

The original article has been corrected. The phrasing of a part of the Abstract has been modified for clarity from "Through stories of loss and healing, we step into the realities of illustrating how women and children experience non-economic wellbeing loss within a climate-violence nexus in Bangladesh, Fiji, and Vanuatu. A storytelling and systems analysis approach guided the analysis of personal narratives gathered through a secondary data review and empirical field work. The research findings identified different pathways through which women and children’s mental health was compromised in the context of structural violence and climatic risks." to "Through stories of loss and healing, we step into the realities of women and children who illustrate how they experience non-economic wellbeing loss within a climate-violence nexus in Bangladesh, Fiji, and Vanuatu. A storytelling and systems approach guided the analysis of personal narratives gathered through a secondary data review and empirical field work. The research findings identified different pathways through which women’s and children’s mental health was compromised in the context of structural violence and climatic risks.

Experimental Study of Bond Strength of Embedded Steel Reinforcement in Vibration-Based 3D Printed Concrete Mortar

Many new construction techniques have been developed in recent years, one of them is Three-Dimensional Concrete Printing (3DCP). It offers many advantages such as reduced human error, minimum manpower usage, and shorter construction period. This technique, however, still needs to be studied further to ensure good quality of constructions. This experimental study aims to investigate the bond strength of embedded steel reinforcement in vibration-based 3DCP mortar. The parameters varied are reinforcement diameter and direction of printing. It is found that average bond stress decreases as reinforcement diameter increases. Furthermore, 3DCP specimens with bars placed parallel to the printing direction have relatively higher bond stresses as compared to the ones with bars placed perpendicularly. As compared to conventional cast specimens, 3DCP specimens have higher bond stresses which might be due to vibration-based 3DCP mortar. Moreover, building code formulas significantly underestimate the bond stresses of vibration-based 3DCP specimens tested in this study

Experimental Study of Bond Strength of Embedded Steel Reinforcement in Vibration-Based 3D Printed Concrete Mortar

Many new construction techniques have been developed in recent years, one of them is Three-Dimensional Concrete Printing (3DCP). It offers many advantages such as reduced human error, minimum manpower usage, and shorter construction period. This technique, however, still needs to be studied further to ensure good quality of constructions. This experimental study aims to investigate the bond strength of embedded steel reinforcement in vibration-based 3DCP mortar. The parameters varied are reinforcement diameter and direction of printing. It is found that average bond stress decreases as reinforcement diameter increases. Furthermore, 3DCP specimens with bars placed parallel to the printing direction have relatively higher bond stresses as compared to the ones with bars placed perpendicularly. As compared to conventional cast specimens, 3DCP specimens have higher bond stresses which might be due to vibration-based 3DCP mortar. Moreover, building code formulas significantly underestimate the bond stresses of vibration-based 3DCP specimens tested in this study

Targeting cancer addiction for SALL4 by shifting its transcriptome with a pharmacologic peptide

Sal-like 4 (SALL4) is a nuclear factor central to the maintenance of stem cell pluripotency and is a key component in hepatocellular carcinoma, a malignancy with no effective treatment. In cancer cells, SALL4 associates with nucleosome remodeling deacetylase (NuRD) to silence tumor-suppressor genes, such as PTEN. Here, we determined the crystal structure of an amino-terminal peptide of SALL4(1-12) complexed to RBBp4, the chaperone subunit of NuRD, at 2.7 Å, and subsequent design of a potent therapeutic SALL4 peptide (FFW) capable of antagonizing the SALL4-NURD interaction using systematic truncation and amino acid substitution studies. FFW peptide disruption of the SALL4-NuRD complex resulted in unidirectional up-regulation of transcripts, turning SALL4 from a dual transcription repressor-activator mode to singular transcription activator mode. We demonstrate that FFW has a target affinity of 23 nM, and displays significant antitumor effects, inhibiting tumor growth by 85% in xenograft mouse models. Using transcriptome and survival analysis, we discovered that the peptide inhibits the transcription-repressor function of SALL4 and causes massive up-regulation of transcripts that are beneficial to patient survival. This study supports the SALL4-NuRD complex as a drug target and FFW as a viable drug candidate, showcasing an effective strategy to accurately target oncogenes previously considered undruggable