Effect of Irrigation to Winter Wheat on the Radiation Use Efficiency and Yield of Summer Maize in a Double Cropping System

In north China, double cropping of winter wheat and summer maize is a widely adopted agricultural practice, and irrigation is required to obtain a high yield from winter wheat, which results in rapid aquifer depletion. In this experiment conducted in 2001-2002, 2002-2003, and 2004-2005, we studied the effects of irrigation regimes during specific winter wheat growing stage with winter wheat and summer maize double cropping systems; we measured soil moisture before sowing (SMBS), the photosynthetic active radiation (PAR) capture ratio, grain yield, and the radiation use efficiency (RUE) of summer maize. During the winter wheat growing season, irrigation was applied at the jointing, heading, or milking stage, respectively. The results showed that increased amounts of irrigation and irrigation later in the winter wheat growing season improved SMBS for summer maize. The PAR capture ratio significantly (LSD, P < 0.05) increased with increased SMBS, primarily in the 3 spikes leaves. With improved SMBS, both the grain yield and RUE increased in all the treatments. These results indicate that winter wheat should be irrigated in later stages to achieve reasonable grain yield for both crops

Chemically induced graphene to diamond transition: a DFT study

The conversion of graphene into diamond is a new way for preparing ultrathin diamond film without pressure. Herein, we investigated the transformation mechanism of surface-hydrogenated bilayer graphene (SHBG) into surface-hydrogenated single-layer diamond (SHSLD) crystal, inserting fifteen kinds of single metal atoms without any pressure, by using the systematical first-principles calculations. Compared with the configuration without metal atom, SHBG can be transformed into SHSLD spontaneously in thermodynamics under the action of single metal atom, and its formation energy can even decrease from 0.82 eV to -5.79 eV under the action of Hf atom. According to our results, the outer electron orbits and atomic radius of metal atom are two important factors that affect the conversion. For the phase transition to occur, the metal atom needs to have enough empty d orbitals, and the radius of the metal atom is in the range of 0.136-0.159 nm. Through further analysis, we find that the p orbitals of carbon atoms and d orbital of metal atom in SHBG will be strongly hybridized, thereby promoting the conversion. The results supply important significance to experimentally prepare diamond without pressure through hydrogenated graphene

Paternal hypercholesterolemia elicits sex-specific exacerbation of atherosclerosis in offspring.

Emerging studies suggest that various parental exposures affect offspring cardiovascular health, yet the specific mechanisms, particularly the influence of paternal cardiovascular disease (CVD) risk factors on offspring cardiovascular health, remain elusive. The present study explores how paternal hypercholesterolemia affects offspring atherosclerosis development using the LDL receptor-deficient (LDLR-/-) mouse model. We found that paternal high-cholesterol diet feeding led to significantly increased atherosclerosis in F1 female, but not male, LDLR-/- offspring. Transcriptomic analysis highlighted that paternal hypercholesterolemia stimulated proatherogenic genes, including Ccn1 and Ccn2, in the intima of female offspring. Sperm small noncoding RNAs (sncRNAs), particularly transfer RNA-derived (tRNA-derived) small RNAs (tsRNAs) and rRNA-derived small RNAs (rsRNAs), contribute to the intergenerational transmission of paternally acquired metabolic phenotypes. Using a newly developed PANDORA-Seq method, we identified that high-cholesterol feeding elicited changes in sperm tsRNA/rsRNA profiles that were undetectable by traditional RNA-Seq, and these altered sperm sncRNAs were potentially key factors mediating paternal hypercholesterolemia-elicited atherogenesis in offspring. Interestingly, high-cholesterol feeding altered sncRNA biogenesis-related gene expression in the epididymis but not testis of LDLR-/- sires; this may have led to the modified sperm sncRNA landscape. Our results underscore the sex-specific intergenerational effect of paternal hypercholesterolemia on offspring cardiovascular health and contribute to the understanding of chronic disease etiology originating from parental exposures

Spatial-temporal manipulations of visible nanosecond sub-pulse sequences in an actively Q-switched Pr:YLF laser

Pulsed visible lasers either by Q-switching or mode locking have been attracting intense attentions both in solid-state laser and fiber laser. Here, we report on the simultaneous manipulation of reconfigurable sub-pulse sequences and customizable high-order vortex beams in an actively Q-switched visible laser. On the one hand, pulse sequences with up to 4 sub-pulses could be generated and fully controlled by means of an acoustic-optic modulator driven by an arbitrary waveform generator. Both pulse number and pulse intensity can be manipulated through the programmable step-signal, which is also theoretically simulated through the rate equations. On the other hand, assisted by the off-axis pumping technique and the astigmatic mode conversion, the laser cavity could emit high-quality vortex beams carrying Laguerre-Gaussian modes up to 30th order. To the best of our knowledge, this is the most flexible active manipulations not only on the intensity distribution of the transverse modes but also on the temporal distribution of the pulse sequences in a visible laser. The versatile manipulating techniques in this work could be immediately implemented into all other solid-state lasers to obtain sub-pulse vortex beams, which may provide enhanced functionality and flexibility for a large range of laser systems

AntGPT: Can Large Language Models Help Long-term Action Anticipation from Videos?

Can we better anticipate an actor's future actions (e.g. mix eggs) by knowing what commonly happens after his/her current action (e.g. crack eggs)? What if we also know the longer-term goal of the actor (e.g. making egg fried rice)? The long-term action anticipation (LTA) task aims to predict an actor's future behavior from video observations in the form of verb and noun sequences, and it is crucial for human-machine interaction. We propose to formulate the LTA task from two perspectives: a bottom-up approach that predicts the next actions autoregressively by modeling temporal dynamics; and a top-down approach that infers the goal of the actor and plans the needed procedure to accomplish the goal. We hypothesize that large language models (LLMs), which have been pretrained on procedure text data (e.g. recipes, how-tos), have the potential to help LTA from both perspectives. It can help provide the prior knowledge on the possible next actions, and infer the goal given the observed part of a procedure, respectively. To leverage the LLMs, we propose a two-stage framework, AntGPT. It first recognizes the actions already performed in the observed videos and then asks an LLM to predict the future actions via conditioned generation, or to infer the goal and plan the whole procedure by chain-of-thought prompting. Empirical results on the Ego4D LTA v1 and v2 benchmarks, EPIC-Kitchens-55, as well as EGTEA GAZE+ demonstrate the effectiveness of our proposed approach. AntGPT achieves state-of-the-art performance on all above benchmarks, and can successfully infer the goal and thus perform goal-conditioned "counterfactual" prediction via qualitative analysis. Code and model will be released at https://brown-palm.github.io/AntGP

Effects of Dicyclohexyl Phthalate Exposure on PXR Activation and Lipid Homeostasis in Mice.

BACKGROUND: Exposure to plastic-associated endocrine disrupting chemicals (EDCs) has been associated with an increased risk of cardiovascular disease (CVD) in humans. However, the underlying mechanisms for this association are unclear. Many EDCs have been shown to function as ligands of the nuclear receptor pregnane X receptor (PXR), which functions as xenobiotic sensor but also has pro-atherogenic effects in&nbsp;vivo. OBJECTIVE: We sought to investigate the contribution of PXR to the adverse effects dicyclohexyl phthalate (DCHP), a widely used phthalate plasticizer, on lipid homeostasis and CVD risk factors. METHODS: Cell-based assays, primary organoid cultures, and PXR conditional knockout and PXR-humanized mouse models were used to investigate the impact of DCHP exposure on PXR activation and lipid homeostasis in vitro and in&nbsp;vivo. Targeted lipidomics were performed to measure circulating ceramides, novel predictors for CVD. RESULTS: DCHP was identified as a potent PXR-selective agonist that led to higher plasma cholesterol levels in wild-type mice. DCHP was then demonstrated to activate intestinal PXR to elicit hyperlipidemia by using tissue-specific PXR-deficient mice. Interestingly, DCHP exposure also led to higher circulating ceramides in a PXR-dependent manner. DCHP-mediated PXR activation stimulated the expression of intestinal genes mediating lipogenesis and ceramide synthesis. Given that PXR exhibits considerable species-specific differences in receptor pharmacology, PXR-humanized mice were also used to replicate these findings. DISCUSSION: Although the adverse health effects of several well-known phthalates have attracted considerable attention, little is known about the potential impact of DCHP on human health. Our studies demonstrate that DCHP activated PXR to induce hypercholesterolemia and ceramide production in mice. These results indicate a potentially important role of PXR in contributing to the deleterious effects of plastic-associated EDCs on cardiovascular health in humans. Testing PXR activation should be considered for risk assessment of phthalates and other EDCs. https://doi.org/10.1289/EHP9262

Myeloid-Specific Deficiency of Pregnane X Receptor Decreases Atherosclerosis in LDL Receptor-Deficient Mice

Abstract The pregnane X receptor (PXR) is a nuclear receptor that can be activated by numerous drugs and xenobiotic chemicals. PXR thereby functions as a xenobiotic sensor to coordinately regulate host responses to xenobiotics by transcriptionally regulating many genes involved in xenobiotic metabolism. We have previously reported that PXR has pro-atherogenic effects in animal models, but how PXR contributes to atherosclerosis development in different tissues or cell types remains elusive. In this study, we generated an LDL receptor-deficient mouse model with myeloid-specific PXR deficiency (PXRΔMyeLDLR−/−) to elucidate the role of macrophage PXR signaling in atherogenesis. The myeloid PXR deficiency did not affect metabolic phenotypes and plasma lipid profiles, but PXRΔMyeLDLR−/− mice had significantly decreased atherosclerosis at both aortic root and brachiocephalic arteries compared with control littermates. Interestingly, the PXR deletion did not affect macrophage adhesion and migration properties, but reduced lipid accumulation and foam cell formation in the macrophages. PXR deficiency also led to decreased expression of the scavenger receptor CD36 and impaired lipid uptake in macrophages of the PXRΔMyeLDLR−/− mice. Further, RNA-Seq analysis indicated that treatment with a prototypical PXR ligand affects the expression of many atherosclerosis-related genes in macrophages in vitro. These findings reveal a pivotal role of myeloid PXR signaling in atherosclerosis development and suggest that PXR may be a potential therapeutic target in atherosclerosis management

Palladium Cobalt-nickel mixed oxides Surface modification Synergistic interaction Lean methane combustion

The effective transformation of lignin is an essential part of realizing the comprehensive utilization of biomass. In this study, a one-pot method for the depolymerization of corn stover lignin used aluminum phosphate (NiAPO-5) zeolite catalyst contained Brønsted acid, Lewis acid and hydrogenation sites was proposed. It was found that the number of Brønsted acid sites was increased after NiAPO-5 was reduced with H2. The yield of monomers and residue were 35.70% and 38.09% at 235 ◦C for 3 h, respectively. The result of 2D HSQC NMR showed that the NiAPO-5 (H2) catalyst significantly affected the cleavage of β-O-4 bonds. The distribution of products and the stability of catalyst revealed that NiAPO-5 (H2) was an efficient catalyst for the depolymerization of lignin

Results from patient-derived xenograft models support co-administration of allopurinol and 6-mercaptopurine to reduce hepatotoxicity and improve event-free survival in pediatric acute lymphoblastic leukemia

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