Characterization of Extragalactic 24micron Sources in the Spitzer First Look Survey

In this Letter, we present the initial characterization of extragalactic 24um sources in the Spitzer First Look Survey (FLS) by examining their counterparts at 8um and R-band. The color-color diagram of 24-to-8 vs. 24-to-0.7um is populated with 18,734 sources brighter than the 3sigma flux limit of 110uJy, over an area of 3.7sq.degrees. The 24-to-0.7um colors of these sources span almost 4 orders of magnitudes, while the 24-to-8um colors distribute at least over 2 orders of magnitudes. In addition to identifying ~30% of the total sample with infrared quiescent, mostly low redshift galaxies, we also found that: (1) 23% of the 24um sources (~1200/sq.degrees) have very red 24-to-8 and 24-to-0.7 colors and are probably infrared luminous starbursts with L(IR)>3x10^(11)Lsun at z>1. In particular, 13% of the sample (660/sq.degrees) are 24um detected only, with no detectable emission in either 8um or R-band. These sources are the candidates for being ULIRGs at z>2. (2) 2% of the sample (85/sq.degrees) have colors similar to dust reddened AGNs, like Mrk231 at z~0.6-3. (3) We anticipate that some of these sources with extremely red colors may be new types of sources, since they can not be modelled with any familiar type of spectral energy distribution. We find that 17% of the 24um sources have no detectable optical counterparts brighter than R limit of 25.5mag. Optical spectroscopy of these optical extremely faint 24um sources would be very difficult, and mid-infrared spectroscopy from the Spitzer would be critical for understanding their physical nature (Abridged).Comment: Accepted for publication in ApJ (Spitzer Special Issue

Obscured and unobscured active galactic nuclei in the Spitzer Space Telescope First Look Survey

Selection of active galactic nuclei (AGN) in the infrared allows the discovery of AGN whose optical emission is extinguished by dust. In this paper, we use the Spitzer Space Telescope First Look Survey (FLS) to assess what fraction of AGN with mid-infrared luminosities comparable to quasars are missed in optical quasar surveys due to dust obscuration. We begin by using the Sloan Digital Sky Survey (SDSS) database to identify 54 quasars within the 4 deg^2 extragalactic FLS. These quasars occupy a distinct region in mid-infrared color space by virtue of their strong, red, continua. This has allowed us to define a mid-infrared color criterion for selecting AGN candidates. About 2000 FLS objects have colors consistent with them being AGN, but most are much fainter in the mid-infrared than the SDSS quasars, which typically have 8 micron flux densities, S(8.0), ~1 mJy. We have investigated the properties of the 43 objects with S(8.0) >= 1 mJy satisfying our AGN color selection. This sample should contain both unobscured quasars, and AGN which are absent from the SDSS survey due to extinction in the optical. After removing 16 known quasars, three probable normal quasars, and eight spurious or confused objects from the initial sample of 43, we are left with 16 objects which are likely to be obscured quasars or luminous Seyfert-2 galaxies. This suggests the numbers of obscured and unobscured AGN are similar in samples selected in the mid-infrared at S(8.0)~1 mJy.Comment: To appear in the ApJS Spitzer Special Issu

Infrared Properties of Radio-Selected Submillimeter Galaxies in the Spitzer First Look Survey Verification Field

We report on submillimeter and infrared observations of 28 radio-selected galaxies in the Spitzer First Look Survey Verification field (FLSV). All of the radio-selected galaxies that show evidence for emission at 850um with SCUBA have Spitzer counterparts at 24um, while only half of the radio-selected galaxies without 850um emission have detectable counterparts at 24um. The data show a wide range of infrared colors (S70/S24 < 5--30, S8/S3.6 < 0.3--4), indicative of a mixture of infrared-warm AGN and cooler starburst dominated sources. The galaxies showing 850um emission have Spitzer flux densities and flux density ratios consistent with the range of values expected for high-redshift (z=1--4) ultraluminous infrared galaxies.Comment: Accepted for Spitzer ApJS Special Edition, 12 pages including 4 figures and 1 tabl

Postcopulatory sexual selection

The female reproductive tract is where competition between the sperm of different males takes place, aided and abetted by the female herself. Intense postcopulatory sexual selection fosters inter-sexual conflict and drives rapid evolutionary change to generate a startling diversity of morphological, behavioural and physiological adaptations. We identify three main issues that should be resolved to advance our understanding of postcopulatory sexual selection. We need to determine the genetic basis of different male fertility traits and female traits that mediate sperm selection; identify the genes or genomic regions that control these traits; and establish the coevolutionary trajectory of sexes

N-terminal modification of VEGF-A C terminus-derived peptides delineates structural features involved in neuropilin-1 binding and functional activity

The interaction between VEGF-A and its neuropilin (NRP) receptors mediates a number of important biological effects. NRP1 and the related molecule NRP2 are widely expressed on multiple tumour types and throughout the tumour vasculature, and are emerging as critical molecules required for the progression of angiogenic diseases. Given the increasing evidence supporting a role for NRP1 in tumour development, there is growing interest in developing inhibitors of NRP1 interactions with VEGF and its other ligands. In order to probe the interaction we synthesised a number of exon 7- and 8-derived bicyclic peptides with N-terminal lipophilic groups and found a simple N-octanoyl derivative (EG00086) to be the most potent and functionally active. Detailed modelling studies indicated that new intramolecular hydrogen bonds were formed, stabilising the structure and possibly contributing to the potency. Removal of a salt bridge between D142 and R164 implicated in VEGF-A binding to neuropilin-1 had a minor effect on potency. Isothermal calorimetry was used to assess binding of EG00086 to NRP1 and NRP2, and the stability of the peptide in serum and in vivo was investigated. EG00086 is a potent blocker of VEGF-promoted cellular adhesion to extracellular matrices, and phosphorylation of p130Cas contributes to this effect

Unveiling the oldest and most massive galaxies at very high redshift

(Abridged) This work explores the existence of high redshift massive galaxies unveiled with Spitzer+IRAC, but missed by conventional selection techniques based on optical and near-infrared observations. To this end, we use the multi-wavelength imaging data available for the GOODS-South field, and select a flux-limited sample from the IRAC 3.6um image to m(AB)<23.26. We confine our study to the galaxies undetected by the optical HST+ACS imaging and close to the detection limit of the K-band image (K>23.5 AB). Our selection unveiled 20 galaxies on which we performed a detailed photometric analysis. For each galaxy, we built an SED based on optical-to-8um photometry to estimate the photo-z and to derive the main galaxies physical properties. The majority of the sample sources show degenerate/bimodal solutions for the photometric redshifts (Abridged). These can either be heavily dust-enshrouded (Av~2-4) starbursts at 210^12 Lsun, or massive post-starburst galaxies in the redshift interval 4<z<9 with stellar masses of 10^11 Msun. One galaxy, the only source in our sample with both an X-ray and a 24um detection, might be an extremely massive object at z~8 detected during a post-starburst phase with concomitant QSO activity (although a lower-z solution is not excluded). Our investigation of Spitzer-selected galaxies with very red SEDs and completely undetected in the optical reveals a potential population of massive galaxies at z>4 which appear to include significant AGN emissions. These sources may be the oldest stellar systems at z~4. These, previously unrecognized, optically obscured objects might provide an important contribution to the massive-end (M>10^11 sun) of the high-z stellar mass function and they would almost double it (Abridged).Comment: Accepted for publication in Astronomy and Astrophysic

Molecular Characterization of the Gastrula in the Turtle Emys orbicularis: An Evolutionary Perspective on Gastrulation

Due to the presence of a blastopore as in amphibians, the turtle has been suggested to exemplify a transition form from an amphibian- to an avian-type gastrulation pattern. In order to test this hypothesis and gain insight into the emergence of the unique characteristics of amniotes during gastrulation, we have performed the first molecular characterization of the gastrula in a reptile, the turtle Emys orbicularis. The study of Brachyury, Lim1, Otx2 and Otx5 expression patterns points to a highly conserved dynamic of expression with amniote model organisms and makes it possible to identify the site of mesoderm internalization, which is a long-standing issue in reptiles. Analysis of Brachyury expression also highlights the presence of two distinct phases, less easily recognizable in model organisms and respectively characterized by an early ring-shaped and a later bilateral symmetrical territory. Systematic comparisons with tetrapod model organisms lead to new insights into the relationships of the blastopore/blastoporal plate system shared by all reptiles, with the blastopore of amphibians and the primitive streak of birds and mammals. The biphasic Brachyury expression pattern is also consistent with recent models of emergence of bilateral symmetry, which raises the question of its evolutionary significance

Analysis of sexual phenotype and prezygotic fertility in natural populations of Fucus spiralis, F. vesiculosus (Fucaceae, Phaeophyceae) and their putative hybrids

In the genus Fucus, the character dioecy/hermaphroditism has undergone multiple state changes and hybridization is possible between taxa with contrasting mating systems, e.g. between the dioecious Fucus vesiculosus and the hermaphrodite F. spiralis. In the context of mating system evolution, we evaluated the potential consequences of hybridization by studying the variation in sexual phenotype and prezygotic fertility. Firstly, as a result of hybridization between the two sexual systems, gender variation may arise depending on the relative importance of genes with large versus small phenotypic effects. We thus qualitatively examined the extent of gender variation within and among individual hybrids in comparison with both parental species. Secondly, if hybridization breaks up co-adapted gene complexes, hybrid fertility may be reduced in comparison with both parental species. Therefore, we also quantified male and female prezygotic fertility in parental species and their hybrids in order to test for reduction in hybrid fitness. A total of 89 sexually mature individuals (20 F. spiralis, 40 F. vesiculosus, 10 hermaphrodite hybrids and 19 dioecious hybrids) were sampled in two geographically distant regions (France and Portugal) and six conceptacles per individual were observed. Within-individual variation was very restricted qualitatively – only one hybrid carried a conceptacle with a different sexual phenotype from the five others – as well as quantitatively. This suggests a simple genetic system for sex determination involving a few genes with major effects. In addition, analyses showed no significant decrease in hybrid fertility compared with parental species. Moreover, hybrids exhibited all sexual phenotypes, suggesting several generations of hybridization and backcrossing and, therefore, that hybrids are reproductively successful. Finally, the occurrence of sterile paraphyses in female and hermaphrodite individuals was interpreted as a relic of male function and suggests that, as in higher plants, evolution from hermaphroditism to dioecy may be the most parsimonious pathway

Reaction rates and transport in neutron stars

Understanding signals from neutron stars requires knowledge about the transport inside the star. We review the transport properties and the underlying reaction rates of dense hadronic and quark matter in the crust and the core of neutron stars and point out open problems and future directions.Comment: 74 pages; commissioned for the book "Physics and Astrophysics of Neutron Stars", NewCompStar COST Action MP1304; version 3: minor changes, references updated, overview graphic added in the introduction, improvements in Sec IV.A.