60 research outputs found

    Error in the Minnesota Gubernatorial Election of 1962

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    ABSTRACT - In the election recount for the governorship of Minnesota in 1962, 1,423 ballots out of 772,994 paper ballots cast (0.18%) were ultimately ruled invalid. Of these, 51.6% were voted for Rolv.aag, the DFL candidate, although 9,981 fewer paper ballots were cast for him than for Andersen, his Republican opponent. Still this was not a sufficiently greater rate of invalidity to cancel Rolvaag\u27s initial lead of 133 vot-es established by a physical recount of all ballots-he had a final plurality of 91. Rolvaag won because more· voters voted for him. Andersen would not have won even if all ballots had been ruled valid

    Minnesota Response to AIDS.

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    AIDS has become a major challenge to the health of Minnesotans. This 1992 report looks at how Minnesota has been responding to the challenge. It examines how widespread HIV/AIDS is in the state and who has it. It looks at what the government response has been and what actions have been taken by community groups. It details how the media have treated HIV/AIDS and how informed the general public is. And it presents an overview of how decisions about HIV/AIDS were made in Minnesota.Supported by an Interactive Research Grant from CURA and the Office of the Vice President for Academic Affairs, University of Minnesota

    Partisan Gerrymandering in the Post-Bandemer Era.

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    Backstrom, Charles; Robins, Leonard; Eller, Scott. (1987). Partisan Gerrymandering in the Post-Bandemer Era.. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/164825

    Genetic Dissection of Acute Ethanol Responsive Gene Networks in Prefrontal Cortex: Functional and Mechanistic Implications

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    Background Individual differences in initial sensitivity to ethanol are strongly related to the heritable risk of alcoholism in humans. To elucidate key molecular networks that modulate ethanol sensitivity we performed the first systems genetics analysis of ethanol-responsive gene expression in brain regions of the mesocorticolimbic reward circuit (prefrontal cortex, nucleus accumbens, and ventral midbrain) across a highly diverse family of 27 isogenic mouse strains (BXD panel) before and after treatment with ethanol. Results Acute ethanol altered the expression of ~2,750 genes in one or more regions and 400 transcripts were jointly modulated in all three. Ethanol-responsive gene networks were extracted with a powerful graph theoretical method that efficiently summarized ethanol\u27s effects. These networks correlated with acute behavioral responses to ethanol and other drugs of abuse. As predicted, networks were heavily populated by genes controlling synaptic transmission and neuroplasticity. Several of the most densely interconnected network hubs, including Kcnma1 and Gsk3β, are known to influence behavioral or physiological responses to ethanol, validating our overall approach. Other major hub genes like Grm3, Pten and Nrg3 represent novel targets of ethanol effects. Networks were under strong genetic control by variants that we mapped to a small number of chromosomal loci. Using a novel combination of genetic, bioinformatic and network-based approaches, we identified high priority cis-regulatory candidate genes, including Scn1b,Gria1, Sncb and Nell2. Conclusions The ethanol-responsive gene networks identified here represent a previously uncharacterized intermediate phenotype between DNA variation and ethanol sensitivity in mice. Networks involved in synaptic transmission were strongly regulated by ethanol and could contribute to behavioral plasticity seen with chronic ethanol. Our novel finding that hub genes and a small number of loci exert major influence over the ethanol response of gene networks could have important implications for future studies regarding the mechanisms and treatment of alcohol use disorders

    Exploring the origin of retail stores in Europe: evidence from Southern Italy from the 6th century BCE to the 3rd century BCE

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    Retail literature reports considerable research on the role that technology has played in retailing as an enabler of change, with emphasis on the shifting of power from retailers to consumers. While scholarly attention has been paid mainly to investigating the current scenario in order to predict future trends and preview retail settings for the coming years, the origins of the retail process, in terms of physical space for selling activities and history of retailing as discipline of business history, is less investigated. Using qualitative data gathered through historical documents and archaeological findings, the present study goes back beyond modern retail settings to explore the origins of points of sales as early as the Magna Graecia period (600 BCE – 300 BCE). Such historical analysis not only offers an insight into the origin of the modern retailing, but also cast broader questions about the degree to which historical interpretations of the growth of retailing have been evolved, by emphasising that after 2000 years, there are still similarities. To the authors’ knowledge, this current study is the first to extend the baseline for such an understanding back a further millennium or so

    Survey research

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    xix, 192 hlm,; ilus,; 21 cm, inde

    Survey Research

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    xv,171 hal.:25 cm. indek
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