Do Cigarette Taxes Make Smokers Happier Than Nonsmokers?

Public health advocates justify cigarette taxes, claiming they discourage smoking, which results in a healthier population. However, the more pertinent issue with which health advocates should be concerned is that of smoker well‐being. In this paper, I investigate whether cigarette taxes make smokers relatively more satisfied than nonsmokers. Additionally, because poor smokers have a higher discount rate than wealthy smokers, and therefore, perceive the tax differently, I explore the effect that income, in conjunction with a cigarette tax increase, has on smokers’ life‐satisfaction. Using cross‐sectional and time‐series data from the 2005‐2010 Behavioral Risk Factor Surveillance System survey, this paper utilizes regression analysis to investigate the effect of cigarette tax on the happiness of smokers relative to nonsmokers and of poor smokers relative to wealthy smokers. Inflation‐adjusted tax data was collected from The Campaign for Tobacco Free Kids and state unemployment rates were collected from the Bureau of Labor Statistics. Inconsistent with the findings of Gruber and Mullainathan (2005), this paper finds that the satisfaction of smokers does not change relative to nonsmokers in response to cigarette taxes, implying that they do not act in a time‐inconsistent manner as was previously thought. In addition, this paper finds some evidence that the satisfaction of low‐income smokers increases relative to high‐income smokers in response to a cigarette tax. Policymakers should consider this result when enacting tax hikes

The Three Laws: The Chinese Communist Party Throws Down the Data Regulation Gauntlet

Criticism of the Chinese Communist Party (CCP) runs a wide gamut. Accusations of human rights abuses, intellectual property theft, authoritarian domestic policies, disrespecting sovereign borders, and propaganda campaigns all have one common factor: the CCP’s desire to control information. Controlling information means controlling data. Lurking beneath the People’s Republic of China’s (PRC) tumultuous relationship with the rest of the world is the fight between nations to control their citizens’ data while also keeping it out of the hands of adversaries. The CCP’s Three Laws are its newest weapon in this data war. One byproduct of the CCP’s emphasis on controlling the narrative is that analyzing the PRC’s laws and policies requires reading between the lines—in the dark, by candlelight. Even the most informed analysis requires assumptions. The Three Laws are no different. Their broad language, drastic penalties, and sweeping scope rule out the traditional tools of statutory interpretation. Ordinary meaning, canons of construction, and legislative history are useless. In the PRC, the law means what the CCP says it means. To understand the Three Laws and predict the associated regulatory risks, lawyers, economists, and politicians alike must think and reason by analogy. This Note offers analyses, case studies, and recommendations that provide practitioners a solid framework to assess a company’s regulatory risk under the Three Laws. First, this Note outlines the guiding tenets of the CCP to understand the motivations behind the Three Laws. Next, it provides case studies of different companies’ relationships with the CCP. Realizing how the CCP has dealt with some of the largest companies in the world—Ant Group, Didi Chuxing, Apple, Tesla—is crucial to understanding the threat of future capricious CCP action. This Note then analyzes alleged CCP hacking campaigns and global influence building so the reader may better understand the types of actions that the CCP undertakes—and fears being done to it by others. Finally, this Note provides recommendations for companies with different levels of exposure to the CCP and its ability to enforce its laws. Ultimately, this Note provides the reader with a primer on an important geopolitical issue: the shadowy battle between the world’s great powers to control their citizens’ information, procure their adversaries’ data, and the ways that the law is being used to further these goals

Peroxidase and Senescence

Kinetin and α, α1 - dipryridyl prevented the rapid decrease of chlorophyll content in oat leaf intact segments senescing in the dark

Advising New Students with Disabilities

This study focuses on students with disabilities' (SWD) transition to and experiences in college using both quantitative and qualitative data. SWD report similar levels of interaction with advisors and faculty, despite the additional contact that accommodations typically require. SWD also persist at lower rates than do their non-disabled peers. On campuses, SWD must contend with decisions about disclosure, seeking accomodations, self-advocacy, college bureaucracy, and time management. Recommendations are to include disabilities as one aspect of campus diversity within orientation programming and created orientation programs specifically designed for SWD and their parents

Peroxidase and Senescence

ABSTRACT Kinetin and a.a'-dipyridyl prevented the rapid decrease of chlorophyll content in detached oat leaves senescing in the dark. In the light, detachment caused a 27-40% rise in peroxidase activity and kinetin enhanced the enzyme in the segments by about 80%. Darkness prevented any detachment-induced rise of the activity and decreased the stimulating action of kinetin and mechanical injury. The effect of dipyridyl on peroxidase activity in the dark was similar to that of kinetin. Kinetin enhanced the same distinctive isoperoxidases under light and dark conditions. Neither horseradish peroxidase nor that extracted from oat leaves showed any ability to hydroxylate free proline in vitro. A system which supposedly led to peroxidase-catalysed proline hydroxylation yielded small amounts of hydroxyproline in the absence of the enzyme. Staining with Fast Blue BB salt in the presence of IAA as a substrate after electrophoresis indicated that all detected oat isoperoxidases had an IAA oxidase activity visually paralleling their peroxidase activity. Crude extracts contained IAA oxidase inhibitors that could be partially or fully removed by dialysis. The possible significance of the rise in peroxidase activity during senescence is discussed

Unilateral Periorbital Swelling in a Pediatric Patient

Infratemporal fossa (ITF) tumors are rare in children and may present with a variety of symptoms. Teratomas are neoplasms derived from the 3 germ layers and approximately 6% to 10% are within the head and neck. Our study discusses one of the first reported cases of teratoma in the ITF in a pediatric patient. A 3-year-old girl presents with 2 years of recurrent monthly left periorbital swelling accompanied by fevers, skin discoloration, and pain. Prior episodes were treated with antibiotics with incomplete resolution. Imaging revealed a cystic lesion centered in the ITF. She was taken for endoscopic endonasal biopsy of the lesion and had no complications. Pathology revealed a mature teratoma composed primarily of pancreatic tissue. Providers should consider masses such as teratoma in the differential for ITF tumors and periorbital edema unresponsive to typical treatment

Sex bias in letters of recommendation and personal statements for otolaryngology residency

Objective: Application for otolaryngology residency is highly competitive, with letters of recommendation (LORs) and applicant personal statements (PSs) representing important components of the application process. However, their inherently subjective nature predisposes them to potential implicit bias. Otolaryngology has historically been predominated by male physicians and while implicit sex bias has been demonstrated in LORs for application to residency of multiple specialties, data is limited for otolaryngology. Methods: LORs and PSs for all otolaryngology applicants to an academic medical center during the 2019-20 and 2020-21 cycles were abstracted. Quantitative analysis was performed using Linguistic Inquiry and Word Count 2015 (LIWC2015), a validated software application designed to analyze various emotional, cognitive, and structural components of written text. Results: LORs written for females were found to be written from a perspective of higher expertise and confidence while LORs written for males were associated with a more honest, personal, and disclosing tone. Moreover, LORs written for female applicants were found to reference achievement and "grindstone" terminology more than those written for men. No differences were observed in any word category between PSs written by male and female applicants. Conclusion: Minor linguistic differences exist in multiple domains between LORs written for male and female applicants for otolaryngology residency. These tended to favor female applicants, with their letters demonstrating higher clout, achievement, and grindstone scores. This trend was unexpected in this historically predominantly male specialty. While differences were statistically significant, the overall difference in an entire letter of recommendation is likely subtle. Level of Evidence: 3

Sinonasal complications of severe acute respiratory syndrome coronavirus-2: A single center case series

Background: The emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has resulted in an unprecedented global pandemic. Most infected patients are either asymptomatic or have mild upper respiratory infection symptoms. However, life-threatening sequelae have been observed. In this report, we reviewed nine cases of patients with severe complications from sinonasal disease in the setting of acute SARS-CoV-2 infection. Methods: IRB approval was obtained prior to study initiation. A retrospective chart review was performed of patients admitted to a tertiary hospital with complex sinonasal symptoms that required otolaryngologic evaluation and management in the setting of concomitant SARS-CoV-2 infection. Results: Nine patients, ranging from ages 3 to 71 years, with sinonasal disease and simultaneous SARS-CoV-2 infection were identified. Initial presentations ranged from asymptomatic infection to mild/moderate disease (nasal obstruction, cough) or more severe sequelae including epistaxis, proptosis, or neurologic changes. SARS-CoV-2 tests were positive from one to 12 days after symptom onset, with three patients receiving SARS-CoV-2-directed treatment. Complex disease presentations included bilateral orbital abscesses, suppurative intracranial infection, cavernous sinus thrombosis with epidural abscess, systemic hematogenous spread with abscess development in four distinct anatomic locations, and hemorrhagic benign adenoidal tissue. Eight of nine patients (88.8%) required operative intervention. Patients with abscesses also required prolonged, culture-directed antibiotic courses. Conclusion: Though most SARS-CoV-2 infections are asymptomatic and/or self-limited, there is significant morbidity and mortality in patients with severe disease sequela as outlined in our reported cases. This suggests early identification and treatment of sinonasal disease in this patient population is critical to minimizing poor outcomes. Further research on the pathophysiology of these atypical presentations is needed. Level of Evidence: 4 (Case Series)

Cryptococcus neoformans Requires a Functional Glycolytic Pathway for Disease but Not Persistence in the Host

Cryptococcus neoformans is an important fungal pathogen of immunocompromised individuals, with a close relative, Cryptococcus gattii, emerging as a serious threat for the immunocompetent. During initial infection, C. neoformans colonizes the airspaces of the lungs, resulting in pneumonia, and subsequently migrates to the central nervous system (CNS). We sought to understand fungal carbon utilization during colonization of these fundamentally different niches within the host, in particular the roles of gluconeogenesis and glycolysis. We created mutants at key points in the gluconeogenesis/glycolysis metabolic pathways that are restricted for growth on lactate and glucose, respectively. A phosphoenolpyruvate carboxykinase mutant (the pck1∆ mutant), blocked for entry of 2- and 3-carbon substrates into gluconeogenesis and attenuated for virulence in a murine inhalation model, showed wild-type (WT) persistence in a rabbit cerebrospinal fluid (CSF) model of cryptococcosis. Conversely, both the pyruvate kinase (pyk1∆) and the hexose kinase I and II (hxk1∆/hxk2∆) mutants, which show impaired glucose utilization, exhibited severely attenuated virulence in the murine inhalation model of cryptococcosis and decreased persistence in the CNS in both the rabbit CSF and the murine inhalation models while displaying adequate persistence in the lungs of mice. These data suggest that glucose utilization is critical for virulence of C. neoformans and persistence of the yeast in the CNS

Outcomes in surgical management of microprolactinomas: an international multi-institutional series

BackgroundProlactinomas represent the most common pituitary adenoma subtype, the majority of which are microprolactinomas. Dopamine agonists (DAs) remain the first-line intervention for microprolactinomas, however, many patients either cannot tolerate DAs or require lifelong therapy to maintain hormonal control. As endoscopic endonasal surgery (EES) continues to revolutionize the surgical management of sellar lesions, we sought to reassess the feasibility and efficacy of early surgical resection for microprolactinoma.MethodsRetrospective chart review from 2010 to 2021 of adults who underwent EES for microprolactinoma was performed across three medical centers. Surgical failure was defined as a need to restart DAs, a serum prolactin level greater than 30ng/mL at last follow-up, tumor recurrence, or a need for reoperation.ResultsA total of 56 patients were identified with a mean age of 32.9 years and an average of 26.4 months of follow-up. The majority had been on DAs preoperatively (98.2%). The most common surgical indications were DA intolerance (73.2%), tumor unresponsiveness (19.6%), and desire for pregnancy (7.1%). Gross total resection was achieved in 51 (91.1%) cases. The overall surgical remission rate was approximately 70% with failures observed in 17 (30.4%) patients. Multivariate logistic regression identified subtotal resection as the only independent predictor of surgical failure (p = 0.038*). The most common postoperative complication was transient arginine vasopressin deficiency (AVP-D) (21.4%). There were no cases of permanent AVP-D, new visual deficits, or cerebrospinal fluid leak.ConclusionsWith a surgical remission rate of nearly 70%, EES represents a safe and viable alternative strategy to long-term DA treatment for microprolactinomas.Metabolic health: pathophysiological trajectories and therap