Why a legal opinion is necessary for electronic records management systems

Ken Chasse argues the case that organizations should obtain a legal opinion from a suitably qualified lawyer to ensure it complies with the law and with relevant standards for electronic records management, because digital data is now judged by the reliability of the electronic records – thus ensuring that a digital record is no better than the quality of the records system in which it is recorded or storedIndex words: electronic records management systems; reliability – electronically-produced record; reliability – electronic records system; legal compliance; legal opinion – special knowledge and experience; records management; law of records management

Analysis of neurodegenerative Mendelian genes in clinically diagnosed Alzheimer disease

Alzheimer disease (AD), Frontotemporal lobar degeneration (FTD), Amyotrophic lateral sclerosis (ALS) and Parkinson disease (PD) have a certain degree of clinical, pathological and molecular overlap. Previous studies indicate that causative mutations in AD and FTD/ALS genes can be found in clinical familial AD. We examined the presence of causative and low frequency coding variants in the AD, FTD, ALS and PD Mendelian genes, in over 450 families with clinical history of AD and over 11,710 sporadic cases and cognitive normal participants from North America. Known pathogenic mutations were found in 1.05% of the sporadic cases, in 0.69% of the cognitively normal participants and in 4.22% of the families. A trend towards enrichment, albeit non-significant, was observed for most AD, FTD and PD genes. Only PSEN1 and PINK1 showed consistent association with AD cases when we used ExAC as the control population. These results suggest that current study designs may contain heterogeneity and contamination of the control population, and that current statistical methods for the discovery of novel genes with real pathogenic variants in complex late onset diseases may be inadequate or underpowered to identify genes carrying pathogenic mutations

Alien Registration- Chasse, Denis (Winslow, Kennebec County)

https://digitalmaine.com/alien_docs/16479/thumbnail.jp

Why a legal opinion is necessary for electronic records management systems

Ken Chasse argues the case that organizations should obtain a legal opinion from a suitably qualified lawyer to ensure it complies with the law and with relevant standards for electronic records management, because digital data is now judged by the reliability of the electronic records – thus ensuring that a digital record is no better than the quality of the records system in which it is recorded or storedIndex words: electronic records management systems; reliability – electronically-produced record; reliability – electronic records system; legal compliance; legal opinion – special knowledge and experience; records management; law of records management

Investigations of Possible Cases of Scurvy in Juveniles from the Kellis 2 Cemetery in the Dakhleh Oasis, Egypt, Through Stable Carbon and Nitrogen Isotopic Analysis of Multiple Tissues

Vitamin C deficiency, or scurvy, is a disease that can occur in humans at any age and has been seen throughout time. Scurvy affects the production of connective tissues, including collagen, which leads to the many symptoms of the disease, including fatigue, anemia, bleeding gums and lost teeth, skeletal changes, and even death. The Kellis 2 cemetery in the Dakhleh Oasis, Egypt, in use from approximately AD 50-360, contains the remains of many juveniles who exhibit skeletal indicators of scurvy. Tissue samples from juveniles who did (n=31) and did not (n=117) exhibit skeletal indicators of scurvy were analyzed isotopically, with the sample including stable carbon (δ13C) and nitrogen (δ15N) isotope values of bone collagen (scurvy =11, non-scurvy =13), hair (scurvy=21, non-scurvy=112), nail (scurvy =10, non-scurvy =44), and skin (scurvy =19, non-scurvy =59). Intra-tissue comparisons were conducted to determine whether this disease affects δ13C and δ15N values sufficiently to distinguish these two groups from one another isotopically. Inter-tissue comparisons between bone collagen and hair were also conducted, with emphasis placed on inter-tissue spacing results and outliers. Mean δ13C and δ15N values for each hair segment were compared to look for early isotopic signals of scurvy. No statistically significant differences were found between any intra-tissue scurvy and non-scurvy cohorts and no obvious indications of the onset of scurvy were seen in the hair segment analyses. The inter-tissue spacing results, however, highlighted some interesting patterns in the bone collagen-to-hair values, especially in regards to the identified outliers that are discussed in more detail. While this study did not detect any significant differences between scurvy and non-scurvy cohorts or early isotopic signals of the disease in hair segments, the inter-tissue spacing results do point to changes between the cohorts that may be attributable to the physiological stress of scurvy and therefore warrants further investigation