HAEMOGRAM OF NIGERIAN MONGREL BITCH AT DIFFERENT STAGES OF THE REPRODUCTIVE CYCLE

The haematologic parameters of the Nigerian Mongrel bitch were investigated at different stages of the reproductive cycle to determine their clinical values. Results showed that red blood cell (RBC) counts were highest during anoestrus, with a mean of 5.09  0.62 x 106/µL, while lowest values were recorded during pregnancy, the difference was significant (P<0.05). White blood cell (WBC) counts, packed cell volume (PCV) and haemoglobin concentration (Hb) showed an increasing pattern from anoestrus to proestrus and then decreased with transition from proestrus to oestrus. Total WBC counts were highest during dioestrus and almost twice the value recorded in pregnancy. It appears that WBC count may be used for pregnancy diagnosis in the Nigerian Mongrel bitch

Suppression of Superconductivity in YBCO/LCMO Superlattices

The competition of superconductivity and magnetism in superlattices composed of alternating YBa$_2$Cu$_3$O$_{7-d}$ and La$_{0.67}$Ca$_{0.33}$MnO$_{3}$ thin films is investigated using low-energy optical spectroscopy. The thickness of the superconducting YBCO layers is varied from 30 nm to 20 nm while the thickness of the magnetic LCMO layers is kept constant at 20 nm. We clearly observe that the superconducting condensate density in the superconducting state of superlattice is drastically reduced by the magnetic subsystem which may be connected with proximity effects that distort the gap symmetry and thus suppress superconductivity.Comment: 4 pages, 4 figure

Development and Charecterization of Caffeine and Quercetin Loaded Nasal Niosomal In-Situ Gel for Treatment of Depression

Caffeine and Quercetin both are used in combination for the treatment of patient with depression as they are adenosine antagonist due to which they elevate the level of neurotransmitters. The study was designed with two aims. First, is to enhance the solubility and bioavailability of BCS Class II i.e. Quercetin; secondly to ease administration of the formulation to the patient with depression. The culmination of this study, the caffeine and quercetin loaded niosomal in-situ gel for nose-to-brain delivery was formulated. Niosomes were prepared and optimized by using definitive screening design whereas, the Niosomal in-situ gel were prepared and optimized using central composite design. The vesicle size of the optimized batch was found to be 0.281±0.26µm. The % EE of all niosomal batches was found to be in a range of 81.52±0.21% to 98.72±0.16% for Caffeine and 94.3±0.31 to 99.73±0.23 for Quercetin and the cumulative % release was found to be in a range of 72.09±0.18% to 103.3±0.26% for Caffeine and 10.9±0.31% to 37.06±0.15% for Quercetin at 4hrs. DSC, FTIR studies were performed for pure drug and optimized niosomal batch. All the gels as per design were formulated, where the Spreadability was found to be in range of 5.1±0.26cm to 7.9±0.16cm and viscosity after gelation in range of 1800±0.11cps to 4780±0.26cps. The % drug permeated was found to be in range of 85.86±0.015% to 98.61±0.024% for Caffeine and 22.65±0.19% to 33.23±0.34% for Quercetin at 6hrs. These results indicated that niosomal In-situ gel can be used to enhance the bioavailability of drug by directly delivering the drug to the brain by avoiding first pass effect

Efficient Computer Forensic Analysis Using Machine Learning Approaches

In this digital era, the number of Cybercrimes is increasing that has resulted in increased number of pending cybercrimes cases such as artifacts as a malware, hacking and cyber fraud or e-harassment. In order to deal with these cases, digital forensics must include the concrete law enforcement in the court of law. In digital forensics, it is challenging task to detect reliable evidence because of worldwide use and advancements in digital communication technologies. Common approaches such as file signature analysis and the data carving can be done using the forensics tools, however, digital evidence examiners are keen to find the relevant data which helps in finding the truth behind the case. To reduce the examination time in the data examination or analysis process, this paper explores the role of unsupervised pattern recognition to identify the notable artefact. The Self-Organising Map (SOM) is used to automatically cluster notable artefacts. In this work, four cases are presented to demonstrate the use of SOM in examining the digital data saved in a CSV format. Multiple SOMs are created including Extension Mismatch SOM that represents the intentional changes done on the default extension of the file in order to hide it from the forensic examiner. Other types of SOM are created for the EXIF Metadata (i.e. MAC attributes). USB Device Attached (Device Make, Device Model, Device ID, Date/Time, Source File, Tags)

Sphingosomes: A Novel Lipoidal Vesicular Drug Delivery System

Vesicular drug delivery system has various advantages thereby improving therapeutic efficacy and by sustaining and controlling action of drugs. Liposomes, sphingosomes, ethosomes, cubosomes, pharmacasomes, niosomes, transferosomes are the newly developed vesicular drug delivery system. This review article mainly deals with the sphingosomal drug delivery system. Sphingosomes are vesicular drug delivery systems in which an aqueous volume is enclosed with sphingolipid bilayer membranes. Sphingosomes has an enhanced area of interest because of their applicability in improving the in vivo delivery of various chemotherapeutic agents, biological macromolecules and diagnostics. Sphingosome has major advantages over other vesicular drug delivery systems like high stability, more in vivo circulation time, high tumor loading efficacy in case of cancer therapy as compared to liposomes, niosomes etc. Sphingosomes are clinically used vesicular delivery system for chemotherapeutic agent, biological macromolecule and diagnostics. This review concluded that sphingosome represents a promising vesicular drug delivery system for a range of possible therapeutic applications

Equilibrium sorption studies for Fluoride content in drinking water of Bore wells of Warud Region on Ferronia Elefuntum Fruit Shell

Major water supply for agriculture and domestic purpose in Warud Region is from Upper Wardha and Shekhadari Dam Water. Even then, resident of most of the areas are mainly dependent on bore well water for domestic and Agriculture purpose especially in summer season. Hence large numbers of bore wells are existed. Fluoride content of selected bore-well water in an around of Warud was analyzed in the month of May, 2011. The study reveals that the fluoride concentration is within the permissible limits in few places as prescribed by BIS and WHO. But in some places it is more than prescribed by BIS and WHO. Hence it is essential to remove these excess fluorides by adsorption

The Ultimate Fate of Supercooled Liquids

In recent years it has become widely accepted that a dynamical length scale {\xi}_{\alpha} plays an important role in supercooled liquids near the glass transition. We examine the implications of the interplay between the growing {\xi}_{\alpha} and the size of the crystal nucleus, {\xi}_M, which shrinks on cooling. We argue that at low temperatures where {\xi}_{\alpha} > {\xi}_M a new crystallization mechanism emerges enabling rapid development of a large scale web of sparsely connected crystallinity. Though we predict this web percolates the system at too low a temperature to be easily seen in the laboratory, there are noticeable residual effects near the glass transition that can account for several previously observed unexplained phenomena of deeply supercooled liquids including Fischer clusters, and anomalous crystal growth near T_g

Identification of genomic biomarkers for anthracycline-induced cardiotoxicity in human iPSC-derived cardiomyocytes: an in vitro repeated exposure toxicity approach for safety assessment.

The currently available techniques for the safety evaluation of candidate drugs are usually cost-intensive and time-consuming and are often insufficient to predict human relevant cardiotoxicity. The purpose of this study was to develop an in vitro repeated exposure toxicity methodology allowing the identification of predictive genomics biomarkers of functional relevance for drug-induced cardiotoxicity in human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). The hiPSC-CMs were incubated with 156 nM doxorubicin, which is a well-characterized cardiotoxicant, for 2 or 6 days followed by washout of the test compound and further incubation in compound-free culture medium until day 14 after the onset of exposure. An xCELLigence Real-Time Cell Analyser was used to monitor doxorubicin-induced cytotoxicity while also monitoring functional alterations of cardiomyocytes by counting of the beating frequency of cardiomyocytes. Unlike single exposure, repeated doxorubicin exposure resulted in long-term arrhythmic beating in hiPSC-CMs accompanied by significant cytotoxicity. Global gene expression changes were studied using microarrays and bioinformatics tools. Analysis of the transcriptomic data revealed early expression signatures of genes involved in formation of sarcomeric structures, regulation of ion homeostasis and induction of apoptosis. Eighty-four significantly deregulated genes related to cardiac functions, stress and apoptosis were validated using real-time PCR. The expression of the 84 genes was further studied by real-time PCR in hiPSC-CMs incubated with daunorubicin and mitoxantrone, further anthracycline family members that are also known to induce cardiotoxicity. A panel of 35 genes was deregulated by all three anthracycline family members and can therefore be expected to predict the cardiotoxicity of compounds acting by similar mechanisms as doxorubicin, daunorubicin or mitoxantrone. The identified gene panel can be applied in the safety assessment of novel drug candidates as well as available therapeutics to identify compounds that may cause cardiotoxicity

Report on Owned Dog Population Survey In Lingayen, Philippines

The Philippines is among the Southeast Asian countries that has a long-standing problem with rabies. About 200 people die of rabies each year in the Philippines, and most are attributed to dog bite cases (Deray, 2015). The sources of infection of more than 95% of human rabies cases worldwide have been reported to be domestic dogs (Cleaveland, et al., 2006). Focusing on the main source rather than the human population, is therefore, the best strategy to eliminate rabies. The World Health Organization (WHO) recommends covering at least 70% of the existing domestic dog population with rabies vaccination in the shortest time possible (WHO, 2015). Experts and epidemiologists also recommend maintaining the population immunity above this critical level for at least twelve months, which also interrupts the transmission of rabies among the target population (Coleman & Dye, 1996; Cleaveland, et al., 2003; Hampson, et al., 2009; Morters, et al., 2013)

Phenomenological Models for the Gap Anisotropy of Bi-2212 as Measured by ARPES

Recently, high resolution angle-resolved photoemission spectroscopy has been used to determine the detailed momentum dependence of the superconducting gap in the high temperature superconductor Bi-2212. In this paper, we first describe tight binding fits to the normal state dispersion and superlattice modulation effects. We then discuss various theoretical models in light of the gap measurements. We find that the simplest model which fits the data is the anisotropic s-wave gap $\cos(k_x)\cos(k_y)$, which within a one-band BCS frame- work suggests the importance of next near neighbor Cu-Cu interactions. Various alternative interpretations of the observed gap are also discussed, along with the implications for microscopic theories of high temperature superconductors.Comment: 14 pages, revtex, 9 uuencoded postscript figure