Dynamic analysis of flexible mechanical systems using LATDYN

A 3-D, finite element based simulation tool for flexible multibody systems is presented. Hinge degrees-of-freedom is built into equations of motion to reduce geometric constraints. The approach avoids the difficulty in selecting deformation modes for flexible components by using assumed mode method. The tool is applied to simulate a practical space structure deployment problem. Results of examples demonstrate the capability of the code and approach

Grey Situation Decision-making Algorithm to Optimize Silicon Wafer Slicing

The slicing of Silicon wafer is a complex manufacturing process in producing the raw materials for electronic chips and requires the efforts to effectively monitor the stability in production line and ensure the quality for the products composed of different shapes and materials. Human decision failure and other analytical errors are the most common source of management problems in such manufacturing stage. This paper presents a case regarding the silicon wafer manufacturing to examine the response to quality errors. The study has adopted the approach of grey situation decision-making algorithm for problem detection that suggests a technique to attain the quality control and reduce potential costs in production

Large Angle Transient Dynamics (LATDYN) user's manual

A computer code for modeling the large angle transient dynamics (LATDYN) of structures was developed to investigate techniques for analyzing flexible deformation and control/structure interaction problems associated with large angular motions of spacecraft. This type of analysis is beyond the routine capability of conventional analytical tools without simplifying assumptions. In some instances, the motion may be sufficiently slow and the spacecraft (or component) sufficiently rigid to simplify analyses of dynamics and controls by making pseudo-static and/or rigid body assumptions. The LATDYN introduces a new approach to the problem by combining finite element structural analysis, multi-body dynamics, and control system analysis in a single tool. It includes a type of finite element that can deform and rotate through large angles at the same time, and which can be connected to other finite elements either rigidly or through mechanical joints. The LATDYN also provides symbolic capabilities for modeling control systems which are interfaced directly with the finite element structural model. Thus, the nonlinear equations representing the structural model are integrated along with the equations representing sensors, processing, and controls as a coupled system

Association between Zolpidem Use and Glaucoma Risk: A Taiwan Population-Based Case-control Study

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Functional Effects of let-7g Expression in Colon Cancer Metastasis.

MicroRNA regulation is crucial for gene expression and cell functions. It has been linked to tumorigenesis, development and metastasis in colorectal cancer (CRC). Recently, the let-7 family has been identified as a tumor suppressor in different types of cancers. However, the function of the let-7 family in CRC metastasis has not been fully investigated. Here, we focused on analyzing the role of let-7g in CRC. The Cancer Genome Atlas (TCGA) genomic datasets of CRC and detailed data from a Taiwanese CRC cohort were applied to study the expression pattern of let-7g. In addition, in vitro as well as in vivo studies have been performed to uncover the effects of let-7g on CRC. We found that the expression of let-7g was significantly lower in CRC specimens. Our results further supported the inhibitory effects of let-7g on CRC cell migration, invasion and extracellular calcium influx through store-operated calcium channels. We report a critical role for let-7g in the pathogenesis of CRC and suggest let-7g as a potential therapeutic target for CRC treatment

Oskar Trautmann, ein deutscher Diplomat in Ostasien : Individuum, Nation und Diplomatie aus der Perspektive der Globalgeschichte 1877-1950

Der deutsche Botschafter in China, Oskar Trautmann, ist durch die Trautmann-Vermittlung kurz nach Ausbruch des Zweiten Chinesisch-Japanischen Krieges weithin bekannt. Dennoch übersehen Forscher sowohl in Deutschland als auch in chinesischsprachigen Wissenschaftskreisen die Studien zu Trautmann selbst lange Zeit. Der Umfang der bisherigen Diplomatiegeschichte beschränkt sich auf „Nationen“ und die Perspektiven wichtiger politischer Persönlichkeiten und übersieht dabei die Begriffsbildung von Diplomatie, die Arbeitsweise der Diplomatie und die Rolle von Vermittlern. Der Cultural Turn, der seit den 1990er Jahren unter dem Einfluss von Linguistik und Kulturanthropologie stattgefunden hat, ermöglicht es der Geschichtswissenschaft, Barrieren durch bisherige Theorien, Methoden und historische Quellen zu durchbrechen. Aus kulturhistorischer Sicht soll Diplomatie als politische Plattform der interkulturellen Kommunikation verstanden werden. Diese Studie unternimmt sowohl theoretisch als auch methodisch Versuche, die Möglichkeit des kulturellen Zugangs zur Erforschung der Diplomatiegeschichte aus einer Globalisierungsperspektive zu untersuchen. Mit dem großen Bestand an persönlichen Journalen, Korrespondenzen und diplomatischen Akten, die Trautmann hinterlassen hat, analysiert diese Studie die diplomatische Geschichte Deutschlands gegenüber Ostasien vor dem Zweiten Weltkrieg und untersucht die persönlichen Konzepte des Diplomaten von Diplomatie, Wissenssystem und persönlichen Gefühlen. Die Studie beantwortet folgende Fragen: Wie beeinflusst ein Diplomat als primärer Agent diplomatischer Arbeit eine diplomatische Beziehung? Welche Faktoren bedingen einen Diplomaten? Wie trifft ein Diplomat eine Entscheidung und erfüllt seine Aufgabe? Wie sieht sich ein Diplomat als Regierungsbürokrat mit Popularisierungs-, Mediatisierungs- und Verstaatlichungswellen konfrontiert? Schließlich untersucht die Studie die Interaktionen und Beziehungen zwischen Trautmann und anderen Diplomaten, um zu untersuchen, wie sich diese Diplomaten durch Kommunikation zu einer besonderen Gruppe von Menschen mit unterschiedlichem kulturellem Hintergrund vernetzten und wie diese Gruppe von Menschen eine moderne diplomatische Arbeitsweise während der Zeit prägte und präsentierte die Entwicklung der Globalisierung.The German Ambassador to China, Oskar Trautmann, is widely known for the Trautmann Mediation shortly after the outbreak of the Second Sino-Japanese War. Nonetheless, researchers in both Germany and Chinese-speaking academic circles have long been overlooking the studies on Trautmann himself. The scope of previous diplomatic history studies is limited to “nations” and the perspectives of important political figures while overlooking the concept formation of diplomacy, operation modes of diplomacy, and the role of mediators. The cultural turn that took place under the influences of linguistics and cultural anthropology since the 1990s enables historical studies to break through barriers set by previous theories, methods, and historical sources. From the angle of cultural history, diplomacy shall be viewed as a political platform for cross-cultural communication. This study makes attempts in both theory and method to explore the possibility of the cultural approach to the study of diplomatic history from a globalization perspective. With the large volume of personal journals, correspondence, and diplomatic files left by Trautmann, this study analyzes the diplomatic history of Germany toward East Asia before WWII, and investigates the diplomat’s personal concepts of diplomacy, knowledge system, and personal sentiments. The study answers the following questions: how does a diplomat, as a primary agent of diplomatic work, influence a diplomatic relation? What factors condition a diplomat? How does a diplomat make a decision and perform his/her duty? How does a diplomat, as a government bureaucrat, face waves of popularization, mediatization, and nationalization? Lastly, the study examines the interactions and relationships between Trautmann and other diplomats to delve into how these diplomats networked through communication to form a special group of people with diversified cultural backgrounds, and how this group of people shaped and presented a modern diplomatic operation mode during the development of globalization

Mining Implicit Patterns of Customer Purchasing Behavior Based On The Consideration Of RFM Model

Association rules have been developed for years and applied successfully for market basket analysis and cross selling among other business applications. One of the most used approaches in association rules is the Apriori algorithm. However the Apriori algorithm, has long known for its weaknesses that generate enormous amount of rules and alreadyknown facts. In this study, we integrate the RFM attributes with the classical association rule mining, Apriori. Based on RFM model, two indicators, RF score and Sale ratio, are used as measure of interestingness. We propose two algorithms, DWRF and DWRFE, to mine for implicit pattern. In our experimental evaluation, the performance of Apriori, DWRF and DWRFE are compared. The result of our algorithms offers an effective measurement of interesting patterns. Moreover, the DWRF algorithm that uses the RF score as a measure of interestingness seems to be able to promptly reflect the fast-changing customer’s purchase patterns