Identities of Transgender People in Ancient Tamil Literature

In human society, it is natural to see two genders, male and female. It is somewhat surprising that the work of transgender people, who can be called the third gender, is somewhat surprising. In the Mahabharatam, the story of the birth of a transsexual is extended. In nature's creation, we find these people incarnated as transsexuals in practical life. The records of transgenders can be found in abundance in Sangam literary grammar. Transgender people, who have been marginalized in society, are denied the right to participate in public. Transgenders living in small groups in the human community have been ridiculed as "identityless." This is the situation today. In the Sangam literary records, their identity has been recognized socially. It can be said that their contribution to the level of education is low. Transgenders, who are marginalized people, are more likely to be rejected at all levels. Since they lacked the right to education, there was no context in grammatical and literary fiction in which the pedis (hermaphrodites), the transgenders, could register their right to life. No one comes forward to help in public, fearing that if they raise their voice for them, they will be respected as untouchables in society. This denial is also a contemporary phenomenon. As a result, it is necessary to compile how third-gender identities are recorded in the literary field. Transgenders, also known as hermaphrodites, exist as records in literary life. The location of such people's lives is clearly visible in grammatical and literary fiction

Asceticism of Jainism as Depicted in Udayanakumara Kaviyam

Jainism, considered to have been created by Rishabadeva has produced numerous literatures in both Tamil and Sanskrit languages. Most of the literature in Tamil language is about Jainism. In particular, Ainchiru Kappiyam explores in detail about the doctrines of Jainism. In Udayanakumara Kaviyam the domestic and ascetic principles of Jainism are explained clearly. Udayanakumara Kaviyam, which is considered to be a summary of Konguvael Makatha, consists of Unjai Kandam, Ilavana Kandam, Magada Kandam and Vathava kandam, Naravagana Kandam and thuravu Kandam and about the 367 hymns. This article clearly explains about the principles of asceticism of Jainism

Nitrogen regulation of protein–protein interactions and transcript levels of GlnK PII regulator and AmtB ammonium transporter homologs in Archaea

Gene homologs of GlnK PII regulators and AmtB-type ammonium transporters are often paired on prokaryotic genomes, suggesting these proteins share an ancient functional relationship. Here, we demonstrate for the first time in Archaea that GlnK associates with AmtB in membrane fractions after ammonium shock, thus, providing a further insight into GlnK-AmtB as an ancient nitrogen sensor pair. For this work, Haloferax mediterranei was advanced for study through the generation of a pyrE2-based counterselection system that was used for targeted gene deletion and expression of Flag-tagged proteins from their native promoters. AmtB1-Flag was detected in membrane fractions of cells grown on nitrate and was found to coimmunoprecipitate with GlnK after ammonium shock. Thus, in analogy to bacteria, the archaeal GlnK PII may block the AmtB1 ammonium transporter under nitrogen-rich conditions. In addition to this regulated protein–protein interaction, the archaeal amtB-glnK gene pairs were found to be highly regulated by nitrogen availability with transcript levels high under conditions of nitrogen limitation and low during nitrogen excess. While transcript levels of glnK-amtB are similarly regulated by nitrogen availability in bacteria, transcriptional regulators of the bacterial glnK promoter including activation by the two-component signal transduction proteins NtrC (GlnG, NRI) and NtrB (GlnL, NRII) and sigma factor σN (σ54) are not conserved in archaea suggesting a novel mechanism of transcriptional control

Modeling the Effects of Passive Immunity in Birds for the Disease Dynamics of West Nile Virus

West Nile Virus (WNV) is a mosquito-borne virus that circulates among birds but also affects humans. Migrating birds carry these viruses from one place to another each year. WNV has spread rapidly across the continental United States resulting in numerous human infections and deaths. Several studies suggest that larval mosquito control measures should be taken as early as possible in a season to control the mosquito population size. Also, adult mosquito control measures are necessary to prevent the transmission of WNV from mosquitoes to birds and humans. To better understand the effective strategy for controlling affected larvae mosquito population, we have developed a mathematical model using a system of first order differential equations to investigate the transmission dynamics of WNV in a mosquito-bird-human community. We also incorporated vertical transmission in mosquitoes and passive immunity in birds to more accurately simulate the spread of the disease

Fatty acid desaturases modulated octadecanoid pathway in Sesame

Omega 3 fatty acid desaturases are involved in the production of α-linolenic acid (LNA) an essential omega 3 fatty acid, which is present in only traces in sesame seeds. LNA is the precursor for jasmonic acid which is the end product of octadecanoid pathway. This study was undertaken to analyze the key components of octadecanoid pathway and its relationship with fatty acid content in sesame. Fatty acid desaturation and membrane fluidity are modulated differentially in various stresses. Sesame seedlings were subjected to transient stress to analyse the octadecanoid pathway and its impact on fatty acid desaturation.  The mRNA levels of omega 3 desaturases and LNA content were higher in cold stressed sesame seedlings than heat, drought and salinity stresses. The LOX activity and MDA content were higher in heat stressed sesame seedlings. Jasmonic acid content was higher in salinity stressed seedlings while abscisic acid registered the highest in drought stressed seedlings. Chloroplast fatty acid desaturase genes expression was found to increase the LNA content in cold stressed seedlings. The level of membrane damage measured by lipid peroxidation in terms of LOX activity and MDA content were found to be minimal in cold stressed seedling. This suggests a possible role of LNA in membrane fluidity and cold acclimation in sesame. A synergistic role of JA and ABA is also suspected in abiotic stress tolerance in sesame

Advanced Brain Tumour Segmentation from MRI Images

Magnetic resonance imaging (MRI) is widely used medical technology for diagnosis of various tissue abnormalities, detection of tumors. The active development in the computerized medical image segmentation has played a vital role in scientific research. This helps the doctors to take necessary treatment in an easy manner with fast decision making. Brain tumor segmentation is a hot point in the research field of Information technology with biomedical engineering. The brain tumor segmentation is motivated by assessing tumor growth, treatment responses, computer-based surgery, treatment of radiation therapy, and developing tumor growth models. Therefore, computer-aided diagnostic system is meaningful in medical treatments to reducing the workload of doctors and giving the accurate results. This chapter explains the causes, awareness of brain tumor segmentation and its classification, MRI scanning process and its operation, brain tumor classifications, and different segmentation methodologies

Emotional Tendency Analysis of Twitter Data Streams

The web now seems to be an alive and dynamic arena in which billions of people across the globe connect, share, publish, and engage in a broad range of everyday activities. Using social media, individuals may connect and communicate with each other at any time and from any location. More than 500 million individuals across the globe post their thoughts and opinions on the internet every day. There is a huge amount of information created from a variety of social media platforms in a variety of formats and languages throughout the globe. Individuals define emotions as powerful feelings directed toward something or someone as a result of internal or external events that have a personal meaning. Emotional recognition in text has several applications in human-computer interface and natural language processing (NLP). Emotion classification has previously been studied using bag-of words classifiers or deep learning methods on static Twitter data. For real-time textual emotion identification, the proposed model combines a mix of keyword-based and learning-based models, as well as a real-time Emotional Tendency Analysi

A Dynamical System Model of Dengue Transmission for Rio de Janeiro, Brazil

The dengue virus is a serious concern in many parts of the world, including Brazil. As data indicates, a prominent vector for dengue is the mosquito Aedes aegypti. By using the dengue incidence records from the Brazilian SINAN database, we estimate the population of A. aegypti within the city of Rio de Janeiro. Using historical climate data for Rio de Janeiro and the computed population estimates, we extend an existing model for the population dynamics of mosquitoes to incorporate precipitation in aquatic stages of development for A. aegypti