Carfilzomib in multiple myeloma: unraveling cardiac toxicities - from mechanisms to diagnosis and management

The survival rates of patients with hematological malignancies such as multiple myeloma have improved with advances in cancer treatment. However, the risk of cardiovascular disease associated with novel therapeutic agents, including proteasome inhibitors (PIs), is becoming increasingly evident. PIs act on proteasome peptidases, leading to cell cycle arrest or apoptosis. Carfilzomib (CFZ), an intravenously administered irreversible PI, exhibits pronounced cardiovascular toxicity that is characterized by heart failure, hypertension, arrhythmia, and ischemic heart disease (IHD). This review focuses on CFZ, details its applications in treating multiple myeloma, presents its potential mechanisms of cardiotoxicity and the incidence of cardiotoxic events, and provides recommendations for the evaluation and management of adverse cardiac events during the early treatment of patients with this drug

Constructing large-size and ultrathin NiCoP nanosheets on an Fe₂O₃ photoanode toward efficient solar water splitting

This work demonstrated the rational construction of a large-size and ultrathin NiCoP cocatalyst on Fe2O3 photoanodes for significantly promoting their water oxidation performances.</jats:p

Crystallization of highly supercooled glass-forming alloys induced by anomalous surface wetting

The embryos preferentially form on the film surface and then develop into stable nuclei with the support of another surface.</p

Ni nanoparticle doped porous VN nanoflakes assembled into hierarchical hollow microspheres with a structural inheritance from the Ni_1−xV_xO₂ cathode material for high performance asymmetric supercapacitors

A Ni/VN 3D HHMS structure was produced via exact structural inheritance from the cathode Ni1−xVxO2. They show enhanced performance when assembled into an ASC.</p

Facile fabrication of BiVO₄ nanofilms with controlled pore size and their photoelectrochemical performances

We demonstrated a facile method for the rational fabrication of pore-size controlled nanoporous BiVO4 photoanodes, and confirmed that the optimum pore-size distributions could effectively absorb visible light through light diffraction and confinement functions.</p

Rapid Diagnosis of Soybean Seedling Blight Caused by <i>Rhizoctonia solani</i> and Soybean Charcoal Rot Caused by <i>Macrophomina phaseolina</i> Using LAMP Assays

A new method of direct detection of pathogenic fungi in infected soybean tissues has been reported here. The method rapidly diagnoses soybean seedling blight caused by Rhizoctonia solani and soybean charcoal rot caused by Macrophomina phaseolina, and features loop-mediated isothermal amplification (LAMP). The primers were designed and screened using internal transcribed spacers (ITS) as target DNAs of both pathogens. An ITS-Rs-LAMP assay for R. solani and an ITS-Mp-LAMP assay for M. phaseolina that can detect the pathogen in diseased soybean tissues in the field have been developed. Both LAMP assays efficiently amplified the target genes over 60 min at 62°C. A yellow-green color (visible to the naked eye) or intense green fluorescence (visible under ultraviolet light) was only observed in the presence of R. solani or M. phaseolina after addition of SYBR Green I. The detection limit of the ITS-Rs-LAMP assay was 10 pg μl–1 of genomic DNA; and that of the ITS-Mp-LAMP assay was 100 pg μl–1 of genomic DNA. Using the two assays described here, we successfully and rapidly diagnosed suspect diseased soybean samples collected in the field from Jiangsu and Anhui provinces. </jats:p

The influence of information on residents’ green housing purchasing behavior: different information contents and providers

To promote consumers to buy green housing, the paper tries to find the effect of information on consumers’ green housing purchasing behavior. It classifies the contents and providers of information and explores their different influences. The results show that: 1) Consumers’ age and environmental protection attitude have a significant impact on their purchasing behavior, while consumers’ gender and monthly income have no significant impact; 2) Consumers are more affected by information relating to the economy and indoor air quality. The detailed order of influence is as follows: information on loan at concessionary rates > cost saving in usage phase > indoor air quality > waste classification > investment benefit > carbon emission reduction > thermal comfort > acoustic environment > greening rate > luminous environment; 3) Consumers with higher environmental awareness care more about the information on living environment and carbon emission. Whereas, those with low awareness of environmental protection are more affected by information on economic benefits. 4) Regarding different information providers, the consumers are mostly impacted by the government, while the information from developers could induce limited effects. It could guide the government and developers to provide appropriate information to promote GH purchasing behavior