Bifurcation analysis of the trans <-> cis rotation of monorotor molecules

[[abstract]]The bifurcation analyses of the internal rotation of three different series of monorotor molecules are investigated in this paper. Our results indicate that the types of catastrophe and topological regions are related to the generic form of potential energy function and the critical points. Namely, when the double-barrier energy function is represented as the third-order generic polynomial of the reduced reaction coordinate, the process is isomorphic to the elementary fold catastrophe. Similarly, when the triple-barrier energy functions are represented as the fourth-order generic polynomial of the reduced reaction coordinate, the process is isomorphic to the elementary cusp catastrophe.[[fileno]]2030149010039[[department]]電機工程學

Adaptive B-spline network control for three-phase PWM AC-DC voltage source converter

Author name used in this publication: D. SutantoVersion of RecordPublishe

Patient complexity and genotype-phenotype correlations in biliary atresia: a cross-sectional analysis

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Modulation of human cardiac transient outward potassium current by EGFR tyrosine kinase and Src-family kinases

Aims: The human cardiac transient outward K + current Ito (encoded by Kv4.3 or KCND3) plays an important role in phase 1 rapid repolarization of cardiac action potentials in the heart. However, modulation of I to by intracellular signal transduction is not fully understood. The present study was therefore designed to determine whether/how human atrial I to and hKv4.3 channels stably expressed in HEK 293 cells are regulated by protein tyrosine kinases (PTKs). Methods and results: Whole-cell patch voltage-clamp, immunoprecipitation, western blotting, and site-directed mutagenesis approaches were employed in the present study. We found that human atrial I to was inhibited by the broad-spectrum PTK inhibitor genistein, the selective epidermal growth factor receptor (EGFR) kinase inhibitor AG556, and the Src-family kinases inhibitor PP2. The inhibitory effect was countered by the protein tyrosine phosphatase inhibitor orthovanadate. In HEK 293 cells stably expressing human KCND3, genistein, AG556, and PP2 significantly reduced the hKv4.3 current, and the reduction was antagonized by orthovanadate. Interestingly, orthovanadate also reversed the reduced tyrosine phosphorylation level of hKv4.3 channels by genistein, AG556, or PP2. Mutagenesis revealed that the hKv4.3 mutant Y136F lost the inhibitory response to AG556, while Y108F lost response to PP2. The double-mutant Y108FY136F hKv4.3 channels showed no response to either AG556 or PP2. Conclusion: Our results demonstrate that human atrial Ito and cloned hKv4.3 channels are modulated by EGFR kinase via phosphorylation of the Y136 residue and by Src-family kinases via phosphorylation of the Y108 residue; tyrosine phosphorylation of the channel may be involved in regulating cardiac electrophysiology. © The Author 2011.postprin

The Effect of Vestibular Stimulation on Eye-Hand Coordination and Postural Control in Elite Basketball Players

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Search for electric dipole moments at storage rings

Permanent electric dipole moments (EDMs) violate parity and time reversal symmetry. Within the Standard Model (SM) they are many orders of magnitude below present experimental sensitivity. Many extensions of the SM predict much larger EDMs, which are therefore an excellent probe for the existence of "new physics". Until recently it was believed that only electrically neutral systems could be used for sensitive searches of EDMs. With the introduction of a novel experimental method, high precision for charged systems will be within reach as well. The features of this method and its possibilities are discussed.Comment: Proc. EXA2011, 6 pages; http://www.springerlink.com/content/45l35376832vhrg0

Effectiveness of additional follow-up telephone counseling in a smoking cessation clinic in Beijing and predictors of quitting among Chinese male smokers

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Patient complexity and genotype-phenotype correlations in biliary atresia: a cross-sectional analysis

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Genetic study of congenital bile-duct dilatation identifies de novo and inherited variants in functionally related genes

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