6,700 research outputs found

    Destination image in travel magazines: A textual and pictorial analysis of Hong Kong and Macau

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    Based on the analyses of texts and pictures in the top six outbound travel magazines in Mainland China, this article presents an evaluation of the destination images of Hong Kong and Macau as portrayed in 88 travel articles over a three-year period. The results showed that the projected destination images of Hong Kong and Macau were dominated by attributes related to culture, history, and art and leisure and recreation. Hong Kong was often described by image attributes such as places and attractions, shopping, cuisine and food, hotels, and the creative industries. For Macau, history and heritage, places and attractions, gambling, cuisine and food, and hotels were the most often reported. During the study period, Hong Kong and Macau witnessed several significant changes in the image attributes featured in both texts and pictures. These changes were partly influenced by news and events over the period. In this article, implications for destination marketing organizations and directions for future research were suggested

    An Evaluation Of Postgraduate School-Based Teacher Education Program In Malaysia

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    PHD 2011 The primary purpose of this study was to evaluate the strengths and weaknesses of the postgraduate SBTE program as an alternative route in training teachers. The post graduate SBTE was conducted by using modules through self-directed learning and tutorials, with the collaboration of the school mentor teachers. Tujuan utama kajian ini adalah untuk menilai kekuatan dan kelemahan program LPBS lepas ijazah sebagai satu kaedah alternatif dalam melatih guru. Program LPBS lepas ijazah dilaksanakan dengan menggunakan modul-modul melalui pembelajaran arah kendiri dan tutorial, dengan kolaborasi guru pembimbing di sekolah

    The psychological impact of a dying child on Chinese family members

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    Author name used in this publication: Alice Cheng LaiAuthor name used in this publication: Thomas Wong2003-2004 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

    Acrylic resin reinforced with high performance polyethylene fiber

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    Abstract no. 1269published_or_final_versio

    Homological algebra for osp(1/2n)

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    We discuss several topics of homological algebra for the Lie superalgebra osp(1|2n). First we focus on Bott-Kostant cohomology, which yields classical results although the cohomology is not given by the kernel of the Kostant quabla operator. Based on this cohomology we can derive strong Bernstein-Gelfand-Gelfand resolutions for finite dimensional osp(1|2n)-modules. Then we state the Bott-Borel-Weil theorem which follows immediately from the Bott-Kostant cohomology by using the Peter-Weyl theorem for osp(1|2n). Finally we calculate the projective dimension of irreducible and Verma modules in the category O

    Determinants of adults' intention to vaccinate against pandemic swine flu

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    This article has been made available through the Brunel Open Access Publishing Fund.This article has been made available through the Brunel Open Access Publishing Fund.Background: Vaccination is one of the cornerstones of controlling an influenza pandemic. To optimise vaccination rates in the general population, ways of identifying determinants that influence decisions to have or not to have a vaccination need to be understood. Therefore, this study aimed to predict intention to have a swine influenza vaccination in an adult population in the UK. An extension of the Theory of Planned Behaviour provided the theoretical framework for the study. Methods: Three hundred and sixty two adults from the UK, who were not in vaccination priority groups, completed either an online (n = 306) or pen and paper (n = 56) questionnaire. Data were collected from 30th October 2009, just after swine flu vaccination became available in the UK, and concluded on 31st December 2009. The main outcome of interest was future swine flu vaccination intentions. Results: The extended Theory of Planned Behaviour predicted 60% of adults’ intention to have a swine flu vaccination with attitude, subjective norm, perceived control, anticipating feelings of regret (the impact of missing a vaccination opportunity), intention to have a seasonal vaccine this year, one perceived barrier: “I cannot be bothered to get a swine flu vaccination” and two perceived benefits: “vaccination decreases my chance of getting swine flu or its complications” and “if I get vaccinated for swine flu, I will decrease the frequency of having to consult my doctor,” being significant predictors of intention. Black British were less likely to intend to have a vaccination compared to Asian or White respondents. Conclusions: Theoretical frameworks which identify determinants that influence decisions to have a pandemic influenza vaccination are useful. The implications of this research are discussed with a view to maximising any future pandemic influenza vaccination uptake using theoretically-driven applications.This article is available through the Brunel Open Access Publishing Fund

    The Cosmic Lens All-Sky Survey: statistical strong lensing, cosmological parameters, and global properties of galaxy populations

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    Extensive analyses of statistical strong gravitational lensing are performed based on the final Cosmic Lens All Sky Survey (CLASS) well-defined statistical sample of flat spectrum radio sources and current estimates of galaxy luminosity functions per morphological type. The analyses are done under the assumption that galactic lenses are well-approximated by singular isothermal ellipsoids and early-type galaxies evolved passively since redshift z1z \sim 1. Depending on how the late-type galaxy population is treated (i.e., whether its characteristic velocity dispersion is constrained or not), we find for a flat universe with a cosmological constant that the present matter fraction of the present critical density Ωm=0.310.14+0.27\Omega_{\rm m} = 0.31^{+0.27}_{-0.14} (68%) for the unconstrained case or 0.400.16+0.280.40^{+0.28}_{-0.16} (68%) for the constrained case, with an additional systematic uncertainty of 0.11\approx 0.11 arising from the present uncertainty in the distribution of CLASS sources in redshift and flux density. For a flat universe with a constant equation of state for dark energy w = pxp_x(pressure)/ρx\rho_x(energy density), we find that w<0.550.11+0.18w < -0.55^{+0.18}_{-0.11} (68%) for the unconstrained case or w<0.410.16+0.28w < -0.41^{+0.28}_{-0.16} (68%) for the constrained case. For the equal frequencies of oblates and prolates, we find that σ(e)=19818+22\sigma_{*}^{(e)} = 198^{+22}_{-18} km s1^{-1} (68%) for a `steep' α(e)=1\alpha^{(e)}=-1 or σ(e)=18115+18\sigma_{*}^{(e)} = 181^{+18}_{-15} km s1^{-1} (68%) for a `shallow' α(e)=0.54\alpha^{(e)}=-0.54. Finally, from the relative frequencies of doubly-imaged sources and quadruply-imaged sources, we find that a mean projected mass ellipticity of early-type galaxies ϵˉmass=0.42\bar{\epsilon}_{\rm mass} = 0.42 with a 68% lower limit of 0.28. (Abridged)Comment: 31 pages, 12figures, 6 tables, to appear in MNRAS (referee comments incorporated, a section on future prospects added

    Time-reversed adapted-perturbation (TRAP) optical focusing onto dynamic objects inside scattering media

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    The ability to steer and focus light inside scattering media has long been sought for a multitude of applications. At present, the only feasible strategy to form optical foci inside scattering media is to guide photons by using either implanted or virtual guide stars, which can be inconvenient and limits the potential applications. Here we report a scheme for focusing light inside scattering media by employing intrinsic dynamics as guide stars. By adaptively time-reversing the perturbed component of the scattered light, we show that it is possible to focus light to the origin of the perturbation. Using this approach, we demonstrate non-invasive dynamic light focusing onto moving targets and imaging of a time-variant object obscured by highly scattering media. Anticipated applications include imaging and photoablation of angiogenic vessels in tumours, as well as other biomedical uses

    NMR Observable-Based Structure Refinement of DAP12-NKG2C Activating Immunoreceptor Complex in Explicit Membranes

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    This is the published version. Copyright 2012 by Elsevier.NMR observables, such as NOE-based distance measurements, are increasingly being used to characterize membrane protein structures. However, challenges in membrane protein NMR studies often yield a relatively small number of such restraints that can create ambiguities in defining critical side chain-side chain interactions. In the recent solution NMR structure of the DAP12-NKG2C immunoreceptor transmembrane helix complex, five functionally required interfacial residues (two Asps and two Thrs in the DAP12 dimer and one Lys in NKG2C) display a surprising arrangement in which one Asp side chain faces the membrane hydrophobic core. To explore whether these side-chain interactions are energetically optimal, we used the published distance restraints for molecular dynamics simulations in explicit micelles and bilayers. The structures refined by this protocol are globally similar to the published structure, but the side chains of those five residues form a stable network of salt bridges and hydrogen bonds, leaving the Asp side chain shielded from the hydrophobic core, which is also consistent with available experimental observations. Moreover, the simulations show similar short-range interactions between the transmembrane complex and lipid/detergent molecules in micelles and bilayers, respectively. This study illustrates the efficacy of NMR membrane protein structure refinements in explicit membrane systems

    A transient homotypic interaction model for the influenza A virus NS1 protein effector domain

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    Influenza A virus NS1 protein is a multifunctional virulence factor consisting of an RNA binding domain (RBD), a short linker, an effector domain (ED), and a C-terminal 'tail'. Although poorly understood, NS1 multimerization may autoregulate its actions. While RBD dimerization seems functionally conserved, two possible apo ED dimers have been proposed (helix-helix and strand-strand). Here, we analyze all available RBD, ED, and full-length NS1 structures, including four novel crystal structures obtained using EDs from divergent human and avian viruses, as well as two forms of a monomeric ED mutant. The data reveal the helix-helix interface as the only strictly conserved ED homodimeric contact. Furthermore, a mutant NS1 unable to form the helix-helix dimer is compromised in its ability to bind dsRNA efficiently, implying that ED multimerization influences RBD activity. Our bioinformatical work also suggests that the helix-helix interface is variable and transient, thereby allowing two ED monomers to twist relative to one another and possibly separate. In this regard, we found a mAb that recognizes NS1 via a residue completely buried within the ED helix-helix interface, and which may help highlight potential different conformational populations of NS1 (putatively termed 'helix-closed' and 'helix-open') in virus-infected cells. 'Helix-closed' conformations appear to enhance dsRNA binding, and 'helix-open' conformations allow otherwise inaccessible interactions with host factors. Our data support a new model of NS1 regulation in which the RBD remains dimeric throughout infection, while the ED switches between several quaternary states in order to expand its functional space. Such a concept may be applicable to other small multifunctional proteins
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