Probing Light Higgsinos in Natural SUSY from Monojet Signals at the LHC

We investigate a strategy to search for light, nearly degenerate higgsinos within the natural MSSM at the LHC. We demonstrate that the higgsino mass range $\mu$ in $100-150$ GeV, which is preferred by the naturalness, can be probed at $2\sigma$ significance through the monojet search at 14 TeV HL-LHC with 3000 fb$^{-1}$ luminosity. The proposed method can also probe certain region in the parameter space for the lightest neutralino with a high higgsino purity, that cannot be reached by planned direct detection experiments at XENON-1T(2017).Comment: references and discussions adde

Gravity Effects on Information Filtering and Network Evolving

In this paper, based on the gravity principle of classical physics, we propose a tunable gravity-based model, which considers tag usage pattern to weigh both the mass and distance of network nodes. We then apply this model in solving the problems of information filtering and network evolving. Experimental results on two real-world data sets, \emph{Del.icio.us} and \emph{MovieLens}, show that it can not only enhance the algorithmic performance, but can also better characterize the properties of real networks. This work may shed some light on the in-depth understanding of the effect of gravity model

Two-Higgs-doublet model with a color-triplet scalar: a joint explanation for top quark forward-backward asymmetry and Higgs decay to diphoton

The excess of top quark forward-backward asymmetry ($A^t_{FB}$) reported by the Tevatron and the enhancement of the Higgs decay to diphoton observed by the LHC may point to a same origin of new physics. In this note we examined such anomalies in the two-Higgs-doublet model with a color-triplet scalar. We found that under current experimental constraints this model can simultaneously explain both anomalies at $1\sigma$ level. Also, we examined the Higgs decay $h\to Z\gamma$ and displayed its correlation with $h\to \gamma\gamma$. We found that unlike other models, this model predicts a special correlation between $h\to Z\gamma$ and $h\to \gamma\gamma$, i.e., the $Z\gamma$ rate is highly suppressed while the $\gamma\gamma$ rate is enhanced. This behavior may help to distinguish this model in the future high luminosity run of the LHC.Comment: 18pages, 4figures, references adde

Metal Injection Moulding of High Nb-Containing TiAl Alloy and Its Oxidation Behaviour at 900°C

High Nb-containing TiAl alloy with a nominal composition of Ti-45Al-8.5Nb-0.2W-0.2B-0.02Y (at %) was fabricated by metal injection moulding (MIM) technology with an improved wax-based binder. The critical powder loading and feedstock rheological behaviour were determined. The influence of sintering temperature on microstructures and mechanical properties of the sintered samples and their oxidation behaviour were also investigated. Results showed that a feedstock, with a powder loading of 68 vol % and good flowability, could be obtained by using the improved binder, and oxygen pick-up was lower than that of the sample prepared by using a traditional binder. The ultimate tensile strength (UTS) and plastic elongation of the sample sintered at 1480 °C for 2 h were 412 MPa and 0.33%, at room temperature, respectively. The 1480 °C-sintered sample consisted of γ/α2 lamellar microstructure with the average colony size of about 70 µm, and its porosity was about 4%. The sintered alloy showed better oxidation resistance than that of the cast alloy counterpart

Adverse Effects of Asparaginase in Pediatric Patients with Acute Lymphoblastic Leukemia

Acute lymphoblastic leukemia (ALL) is the most common type of childhood cancer. Asparaginase is a critical treatment component for ALL. However, its use is complicated by adverse effects, such as hypersensitivity, osteonecrosis and pancreatitis. Hypersensitivity to asparaginase typically requires discontinuation of current formulation and substitution with other formulations, but the differential diagnosis can be challenging, and the diagnostic utility of antibody tests is unclear. We comprehensively analyzed anti-Elspar (native E.coli asparaginase) IgG antibodies in 410 pediatric patients treated on an asparaginaseintensive front-line clinical trial. Of 169 patients (41.2%) who exhibited clinical allergy, 147 (87.0%) were positive for anti-Elspar antibody. Of 241 patients without clinical allergy, 89 (36.9%) had detectable antibody. Among those positive for antibody, the antibody titers were higher in those who developed allergy than in those who did not (P \u3c 1.0 × 10-15). Antibody measures at week 7 of continuation therapy had a sensitivity of 87%-88% and a specificity of 68%-69% for predicting or confirming clinical reactions. Antibodies were inversely associated with serum asparaginase activity (P = 7.0 × 10-6 ). Interestingly, high antibodies were associated with a lower risk of osteonecrosis (odds ratio = 0.83; 95% confidence interval, 0.78-0.89; P = 0.007), which is a dose-limiting adverse effect of glucocorticoids but has also been linked to asparaginase treatment. We conclude that antibodies were related to clinical allergy and to low systemic exposure to asparaginase, leading to lower risk of other adverse effects of therapy. Measures of serum antibodies to asparaginase can be useful in patients with ALL. Osteonecrosis is a common dose-limiting toxicity of glucocorticoids. Data from clinical trials suggest that other medications can increase the risk of glucocorticoid-induced osteonecrosis. Here we utilized a mouse model to study the effect of asparaginase treatment on dexamethasone-induced osteonecrosis. After 6 weeks of treatment, mice receiving asparaginase along with dexamethasone had a higher rate of osteonecrosis than those receiving only dexamethasone (44% vs. 10%, P = 0.006). Primary epiphyseal arteriopathy, an initiating event for osteonecrosis, was observed in 58% of mice receiving asparaginase and dexamethasone compared to 17% of mice receiving dexamethasone only (P = 0.007). As in the clinic, greater exposure to asparaginase was associated with greater plasma exposure to dexamethasone (P = 0.0001). This model also recapitulated other clinical risk factors for osteonecrosis, including age at start of treatment, and association with the systemic exposure to dexamethasone (P = 0.027) and asparaginase (P = 0.036). We conclude that asparaginase can potentiate the osteonecrotic effect of glucocorticoids. Acute pancreatitis is a serious complication of asparaginase with no definitive treatment. Risk factors for asparaginase-induced pancreatitis, especially the genetic predisposition, have not been clearly identified. We studied 5398 pediatric patients with ALL and showed that older age, higher exposure to asparaginase, higher Native American ancestry or African ancestry were independent clinical risk factors for pancreatitis. To determine genetic risk factors, we performed a genome-wide association study. A rare nonsense variant rs199695765 in CPA2, a pancreatic enzyme, was highly associated with pancreatitis (odds ratio = 588, 95% confidence interval 66.8- 5166, P = 9.0 ×10-9 ). A gene-level analysis showed an excess of additional CPA2 variants in those who did versus did not develop pancreatitis (P = 0.018). Furthermore, common variants in genes critical to purine metabolism and cytoskeleton function were also associated with development of pancreatitis. Our findings are consistent with a mixed genetic architecture underlying serious adverse drug effects, wherein a combination of rare but highly penetrant and common but weakly penetrant genetic risk factors contribute to genetic risk. For the patients carrying the highly penetrant variants, consideration should be given to treatment with a nonasparaginase containing ALL chemotherapy regimens. Overall, we studied the major adverse effects of asparaginase in patients treated for ALL. These findings will provide important guidance for precision medicine

Stability and pricing in Naor's model with arrival rate uncertainty

Naor's observable queueing model describes an M/M/1 queue with strategic customers and a system manager who maximizes the long-run average revenue rate or social benefit rate. Customers have identical service values and waiting time costs, assuming the waiting cost is linear in time. A new customer chooses to either enter the system or balk after observing the queue length. The system manager decides on the admission fee, which is assumed to be a constant. The results of Naor's model are: the optimal policy for customers is a threshold policy, and customers enter if and only if the queue length is no larger than a threshold; the revenue-maximizing threshold is no larger than the socially optimal threshold, or equivalently, a revenue maximizer (RM) charges a fee no less than a social optimizer (SO). This research studies an observable queueing system in which the arrival rate is not known with certainty by either customers or the system manager. The customer population is modeled to be either homogeneous or heterogeneous. We present three different models: static pricing with uncertain arrival rate and heterogeneous customers; state dependent pricing with uncertain arrival rate and homogeneous customers; and state dependent pricing with uncertain arrival rate and heterogeneous customers. We study the system stability, the optimal behavior of customers and the optimal pricing policies of the system manager.Mechanical Engineerin

A Reflective Study on Intercultural Transmission and Appreciation among Silk Road Countries

The paper firstly introduces the Belt and Road Initiative proposed by China with a global vision and long-term benefits advocating comprehensive cooperation among the Silk Road countries in infrastructure, politics, economy, finance and culture. Then it focuses on the theoretical analysis of culture, intercultural communication and cultural effects of the ancient Silk Road which had been transformed from a trading route to a comprehensive one containing economic ties, political trust, cultural exchange and common prosperity. The economic energy and cultural vitality of this ancient road is revived under the Belt and Road Initiative framework in accordance with the principles listed in the third part of the paper including respecting different cultural concepts, contributing our new thoughts, understanding other cultures with cultural empathy and making mutual choices in cultural interaction. Our great mission today is to contribute to the common development in and beyond cultures and ultimately attain the goal of building a community of shared future for all humankind

A Creative Design and Implementation of Student-led Flipped Classroom Model in English Learning

The paper begins with the introduction of the origin and wide application of flipped classroom model (hereafter refers to as FCM) in American schools, and then analyzes the basic connotations and framework of FCM with creative thinking. Five famous American FCMs are illustrated in detail and compared in different areas, which are used for reference in the design of our own future class. The highlight and creation of the paper is presented in Part III expounding the creative design and practice of Student-led FCM in English learning in Chinese high schools. It includes the elaborate design of pre-class independent learning with two indispensable components of Chinese FCM: micro-course and in-class activity learning with group discussion. The paper finally demonstrates a case study of Student-led FCM in English class designed and implemented by the students in Dalian Yuming Senior High School tentatively, providing inspiration and references for the creative application of Student-led FCM in Chinese high schools