5 research outputs found
Mapping the human genetic architecture of COVID-19
- Author
- Abdelrazik M.
- Abdullah T.
- Abe R.
- Abe S.
- Abecasis G. R.
- Abel L.
- Abernathy C.
- Abraheem A.
- Abul-Husn N. S.
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- Publication date
- 01/01/2021
- Field of study
Get PDFThe genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-191,2, host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across 19 countries. We report 13 genome-wide significant loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of these loci correspond to previously documented associations to lung or autoimmune and inflammatory diseases3–7. They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated with COVID-19 was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks. This working model of international collaboration underscores what is possible for future genetic discoveries in emerging pandemics, or indeed for any complex human disease
A second update on mapping the human genetic architecture of COVID-19
- Author
- Abd Elghafar MS
- Abdel-Aziz M
- Abdelrazik M
- Abdullah MS
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- Vasilevska-Ristovska J
- Vassell K
- Vedage D
- Veerapen K
- Vega J
- Vehreschild MJGT
- Velasco DG
- Velázquez-Cruz R
- Venkatesh H
- Verdugo RA
- Verdugo RA
- Vergasova E
- Verlander M
- Vertue M
- Verula J
- Vigueras-Hernández A
- Vigurs C
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- Vitart V
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- Vlasschaert C
- Vochin A
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- Von Hohenstaufen Puoti KA
- Voza A
- Vuylsteke A
- Várnai R
- Vázquez-Pérez JA
- Wacker EM
- Wackett T
- Wadams B
- Waddell G
- Waddington N
- Wagner R
- Wagstaff V
- Waite AAC
- Wakabayashi A
- Wakahara K
- Wakefield P
- Wakinshaw F
- Waldron J
- Walker C
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- Walker R
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- Yatomi M
- Ye C
- Yermakovich D
- Yeung RSM
- Yi X
- Yonekawa A
- Yoo S
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- Yoshida S
- Yoshida T
- Yoshihara T
- Yoshiya K
- Yoshiyama T
- Young M
- Yue F
- Yun N
- Yáñez CE
- Yáñez Z
- Zainulabid UA
- Zainy T
- Zak A
- Zaki A
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- Zamudio IPM
- Zanella A
- Zapata-Contreras D
- Zapatamartinez M
- Zarate R
- Zarei N
- Zavaleta DAF
- Zawadzki P
- Zawati MH
- Zborowski AC
- Zeberg H
- Zechner M
- Zhang Q
- Zhao X
- Zheng C
- Zheng T
- Zhlawi HJ
- Zhlawi MWJ
- Zholdybayeva E
- Zhou W
- Zhu W
- Zitter L
- Zoller H
- Zongo O
- Zorloni C
- Zuñiga-Pacheco P
- Zárate RN
- Zúñiga-Ramos J
- Álvarez BG
- Ávila-Arcos MA
- Ávila-Arcos MC
- Özer O
- Überla K
- Þorsteinsdóttir U
- Publication venue
- Nature Research
- Publication date
- 21/06/2023
- Field of study
Get PDFMapping the human genetic architecture of COVID-19
- Author
- Abdelrazik M
- Abdullah T
- Abe R
- Abe S
- Abecasis GR
- Abel L
- Abernathy C
- Abraheem A
- Abul-Husn NS
- Acosta-Herrera M
- Acquilini D
- Acquilini D
- Adachi T
- Adachi Y
- Adams C
- Adams K
- Adanini O
- Adeleye O
- Adeniji K
- Adra D
- Afifi N
- Afilalo J
- Afilalo M
- Afolabi D
- Afrasiabi Z
- Afset JE
- Agasou A
- Aghemo A
- Agranoff D
- Agrawal S
- Aguirre LA
- Agwuh K
- Ahmad HF
- Ahmad N
- Ahmed A
- Ahmed C
- Ahmed KA
- Ai M
- Ail D
- Akeroyd L
- Akhtar MN
- Akhtar S
- Akinkugbe O
- Aksentijevich A
- Al Thani A
- Al-Muftah W
- Al-Sarraj Y
- Alarcon C
- Alarcon-Riquelme ME
- Alasdair F
- Alaverdian D
- Alavere H
- Albertos R
- Albillos A
- Albrecht W
- Albrich W
- Albrich WC
- Aldera EL
- Aldridge J
- Alegria A
- Alex B
- Alexander P
- Alfonso J
- Algera AG
- Ali A
- Ali IMA
- Ali S
- Aliberti S
- Allan A
- Allan E
- Allan J
- Alldis Z
- Allen L
- Allen S
- Allibone S
- Allison KS
- Allos R
- Ally SM
- Almaden-Boyle C
- Altabaibeh A
- Altmueller J
- Alvaro A
- Amar D
- Amin V
- Amitrano S
- Amiya S
- Ampuero J
- Anan R
- Anania S
- Anastasescu E
- Anderson F
- Anderson J
- Anderson M
- Anderson P
- Anderson S
- Anderson S
- Anderson T
- Ando A
- Andolfo I
- Andrade V
- Andretta F
- Andreucci E
- Andreucci E
- Andrew A
- Andrew B
- Andrew G
- Andrews E
- Andrews SJ
- Andrews SJ
- Andrews SJ
- Andrews SJ
- Andrikopoulos P
- Anedda F
- Aneli S
- Anemoli V
- Angelini C
- Angus B
- Annis A
- Antcliffe D
- Antinori A
- Antoni MD
- Anumakonda V
- Anwar M
- Anzai T
- Apetri E
- Arai D
- Arana E
- Arbane G
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- Arciero E
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- Arif S
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- Armstrong R
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- Artuso R
- Arumugam P
- Asakura T
- Asano K
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- Ascolillo S
- Ashish A
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- Ashraf S
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- Ashworth M
- Asiimwe IG
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- Asselta R
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- Atkinson D
- Atkinson EG
- Attwood B
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- Butler-Laporte G
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- Butterworth AS
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- Cavazza A
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- Cawthron K
- Cazzaniga M
- Cea C
- Cecconi M
- Ceri S
- Ceri S
- Ceriotti F
- Cerny A
- Cerrato L
- Chablani M
- Chadbourn I
- Chadwick D
- Chadwick D
- Chambler D
- Chan G
- Chan R
- Chand M
- Chandler B
- Chang D
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- Chang X
- Chang Y
- Chapman S
- Charles B
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- Charney AW
- Charnock R
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- Chassot J
- Chaudhary K
- Chavan S
- Chechi K
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- Cherubini A
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- Chihara Y
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- Chiu A
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- Chukkambotla S
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- Cirulli ET
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- de Gordoa LO-R
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- De Grandi A
- de Jong H
- de Jong MD
- De la Horra C
- De Neef M
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- de Rojas I
- de Salazar A
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- De Vivo O
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- Deacon B
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- Death Y
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- Doonan R
- Dopazo X
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- Dunham I
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- Durrant G
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- Dutta AK
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- Publication venue
- Publication date
- 01/01/2021
- Field of study
Get PDFThe genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-191,2, host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across 19 countries. We report 13 genome-wide significant loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of these loci correspond to previously documented associations to lung or autoimmune and inflammatory diseases3,4,5,6,7. They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated with COVID-19 was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks. This working model of international collaboration underscores what is possible for future genetic discoveries in emerging pandemics, or indeed for any complex human disease
Heart failure in Europe: Guideline-directed medical therapy use and decision making in chronic and acute, pre-existing and de novo, heart failure with reduced, mildly reduced, and preserved ejection fraction – the ESC EORP Heart Failure III Registry
- Author
- Abdel Ghany M.
- Abdelali S.
- Abdelghany M.
- Abdelhady Ahmed Y. A.
- Abdelhamid M.
- Abdelhamid M.
- Abdelhamid M.
- Abdelnabi M. H.
- Abdelrahman M. F.
- Abdeltawab A.
- Abderrazak S.
- Abdin A.
- Abdullaev T.
- Abdullaev T.
- Abidi G.
- Acet H.
- Adlam D.
- Adlam D.
- Adnan K.
- Adorno D.
- Aganovic K.
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- Agostinho J.
- Agostoni P.
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- Aidargaliyeva N.
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- Publication venue
- Publication date
- 01/01/2024
- Field of study
No full textAims We analysed baseline characteristics and guideline-directed medical therapy (GDMT) use and decisions in theEuropean Society of Cardiology (ESC) Heart Failure (HF) III Registry. Methods and results Between1November 2018and31December 2020,10162 patients with acute HF (AHF, 39%, age 70 [62-79],36% women) or outpatient visit for HF (61%, age 66 [58-75], 33% women), with HF with reduced (HFrEF, 57%),mildly reduced (HFmrEF,17%) or preserved (HFpEF, 26%) ejection fraction were enrolled from 220 centres in 41European or ESC-affiliated countries. With AHF, 97% were hospitalized, 2.2% received intravenous treatment in theemergency department, and 0.9% received intravenous treatment in an outpatient clinic. AHF was seen by most bya general cardiologist (51%) and outpatient HF most by a HF specialist (48%). A majority had been hospitalized forHF before, but 26% of AHF and 6.1% of outpatient HF had de novo HF. Baseline use, initiation and discontinuation ofGDMT varied according to AHF versus outpatient HF, de novo versus pre-existing HF, and by ejection fraction. Afterthe AHF event or outpatient HF visit, use of any renin-angiotensin system inhibitor, angiotensin receptor-neprilysininhibitor, beta-blocker, mineralocorticoid receptor antagonist and loop diuretics was 89%, 29%, 92%, 78%, and 85%in HFrEF; 89%, 9.7%, 90%, 64%, and 81% in HFmrEF; and 77%, 3.1%, 80%, 48%, and 80% in HFpEF. ConclusionUse and initiation of GDMT was high in cardiology centres in Europe, compared to previous reports from cohortsand registries including more primary care and general medicine and regions more local or outside of Europe andESC-affiliated countries....................................
Mapping the human genetic architecture of COVID-19
- Author
- A. A. Roger Thompson
- A. Cerny
- A. Conen
- A. Guillet
- A. Gulati
- A. H. Koos Zwinderman
- A. Meikle
- A. Munting
- A. Perret
- Aarno Palotie
- Aarno Palotie
- Aaron Blandino Ortiz
- Aaron Butler
- Aarti Shah
- Aayesha Kazi
- Abdelhakim Altabaibeh
- Abdul Ashish
- Abdul Kayani
- Abhinav Gupta
- Abigail Crew
- Abigail Knighton
- Abigail Short
- Abigail Taylor
- Abiola Harrison
- Achille Iolascon
- Adam Auton
- Adam Brayne
- Adam Brown
- Adam Finn
- Adam Loveridge
- Adam S. Butterworth
- Adam Wolverson
- Adama Fofano
- Adeline Busson
- Adolfo de Salazar
- Adolfo Garrido Chercoles
- Adriana Botello
- Adriana Garmendia
- Adriana Palom
- Adrie Kromhout
- Agilan Kaliappan
- Agilan Kaliappan
- Agnese Verzuri
- Agnieska Szemiel
- Agnieszka Kubisz-Pudelko
- Agostino Ognibene
- Agostino Riva
- Agustín Albillos
- Agustín Ruiz
- Ahilanadan Dushianthan
- Ahmed Zaki
- Ahna Girshick
- Ahsan Khan
- Ai Nakamura
- Ailbhe Brady
- Ailsa Golightly
- Ailstair Nichol
- Ainhi Mac
- Aislynn Taggart
- Ajay Raithatha
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- Akihiko Kawana
- Akihiko Tanaka
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- Akihiro Ono
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- Akiko Yonekawa
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- Nycola Muchenje
- O. Clerc
- O. Hügli
- O. Manuel
- O. Marchetti
- O. Pantet
- Obiageri Ezeobu
- Ole Bernt Lenning
- Oleksandra Prysyazhna
- Oliver A. Cornely
- Oliver Jones
- Oliver Koch
- Oliver Mercer
- Oliver Mitchelmore
- Oliver Polgar
- Oliver Smith
- Oliver Witzke
- Olivia Barada
- Olivia Kelsall
- Olivia V. Swann
- Olivia Walton
- Olivier Delaneau
- Olivier Malaise
- Olivier Zongo
- Olugbenga Akinkugbe
- Olumide Adeleye
- Olumide Olufuwa
- Oluronke Adanini
- Onur Özer
- Orazio Palmieri
- Oreste De Vivo
- Osamu Narumoto
- Oslem Dincarslan
- Osoul Chouchane
- Owen Richards
- P. Filippidis
- P. Matthew Ridley
- P. Montillier
- P. O’Brien
- P. Vollenweider
- P. Y. Bochud
- P. Y. Bochud
- Padmasayee Papineni
- Pall Melsted
- Palwendé Romuald Boua
- Pamela Bremmer
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- Panteleimon Takis
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- Paola Petrocelli
- Paoletta Preatoni
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- Paul Boutros
- Paul Bradley
- Paul Collini
- Paul Dark
- Paul Dark
- Paul Elbers
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- Paul Klenerman
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- Paul O’Reilly
- Paul Paul
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- Peter W. Horby
- Peter Young
- Petra Bacher
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- Petros Andrikopoulos
- Phil Donnison
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- Philipp Koehler
- Philipp Schommers
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- Phillip Febbo
- Phillip Suwalski
- Phillipa Wakefield
- Phoebe Coghlan
- Pier Giorgio Scotton
- Pierpaolo Parravicini
- Pierre Lepage
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- Prabhu Arumugam
- Prad Shanmuga
- Pradeep Shanmugasundaram
- Pradeep Subudhi
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- Priya Daniel
- Priyai Parkinson
- Pärt Peterson
- Qin Qin Huang
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- Qingbo Wang
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- Raili Allos
- Raimonds Rescenko
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- Raitis Peculis
- Rajdeep Sandhu
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- Ruth Worner
- Ruth Zárate
- Ruud A. Wolterman
- Ryan C. Thompson
- Ryan Howle
- Ryan O’Leary
- Ryan S. Thwaites
- Ryan Shaw
- Ryuji Koike
- Ryusuke Anan
- Ryuya Edahiro
- Ryuzo Abe
- S. Bibert
- S. Estoppey Younes
- S. Foucras
- S. Gonseth Nussle
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- Samantha L. Barlow
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- Sameer Chavan
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- Samia Hussain
- Samina Ashraf
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- Samiran Ray
- Sammra Haider
- Samreen Ijaz
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- Sanal Jose
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- Sandra Greer
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- Sandro Mancarella
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- Sara Bennett
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- Sara Pigazzini
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- Sarah Beavis
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- Sarah Shelton
- Sarah Shepardson
- Sarah Stone
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- Sarala Perumal
- Sarwat Arif
- Sasha Carter
- Satoru Beppu
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- Satoru Hashimoto
- Satoru Miyano
- Satoru Miyawaki
- Satoru Sakagami
- Satoshi Fuke
- Satoshi Ito
- Satoshi Okamori
- Sauro Luchi
- Saverio Giuseppe Parisi
- Saye Khoo
- Sayoko Ishihara
- Schvearn Allen
- Scott Latham
- Scott T. Weiss
- Scott Warden
- Sean Cutler
- Sean Keating
- Sebastian Zöllner
- Seishi Ogawa
- Seiya Imoto
- Selina Rolker
- Selva Panchatsharam
- Semira Gonseth Nussle
- Serafina Valente
- Serena Aneli
- Serena Ludovisi
- Serena Pelusi
- Sergey A. Kornilov
- Sergio Daga
- Seungho Ryu
- Seán Keating
- Shadia Khandaker
- Shahedal Bari
- Shaheen Akhtar
- Shaman Jhanji
- Shameer Gopal
- Shamiso Masuko
- Shane McIvor
- Shang-Kuan Lin
- Shannon McCurdy
- Shapna Hussain
- Sharon Turney
- Shaun Dabe
- Shauna Bartley
- Shawn N. Murphy
- Shawneequa Callier
- Shea J. Andrews
- Sheena Quaid
- Shefa Miah
- Shefali S. Verma
- Sheila M. O’Byrne
- Sheila Morris
- Sheila Mtuwa
- Sheila Munt
- Shereen Bano
- Shico Visuvanathan
- Shigefumi Nakano
- Shigeki Fujitani
- Shigeru Chiba
- Shin Ohta
- Shin-Woo Kim
- Shiney Cherian
- Shinichi Hayashi
- Shinichi Ogawa
- Shinji Abe
- Shinji Ogura
- Shinji Ozaki
- Shinnosuke Ikemura
- Shinwon Lee
- Shiranee Sriskandan
- Shirley Sutton
- Shoichi Ihara
- Shoichiro Ishihara
- Shoji Suzuki
- Shona C. Moore
- Shona C. Moore
- Shona C. Moore
- Shondipon Laha
- Shondipon Laha
- Shotaro Chubachi
- Shozo Yoshida
- Shruti Agrawal
- Shuichi Yoshida
- Shuji Tohda
- Shuko Mashimo
- Shunsuke Maeda
- Shuying Wei
- Sian Gibson
- Sian Jones
- Sian Saha
- Sibet Joseph
- Sibylle Wilfling
- Siddharth Bakshi
- Siegfried Goerg
- Silvano Bosari
- Silvia Baroni
- Silvia Cappelli
- Silvia Rojo Rello
- Silvia Tavares
- Simon Booth
- Simon Oxspring
- Simon White
- Simon Whiteley
- Simona Dei
- Simona Marcantonio
- Simona Sarzi-Braga
- Simonas Juzenas
- Simone Furini
- Simone Rubinacci
- Sin Young Ham
- Sinduya Srikaran
- Sinead Donlon
- Sinead Kelly
- Siobhain Carmody
- Sivarupan Selvanayagam
- Slayton J. Underwood
- Sneha Basude
- Soeren Metelmann
- Sofia Melo
- Sohei Nakayama
- Soichiro Ueda
- Sonia Liggi
- Sonia Sathe
- Sonia Sousa Arias
- Sonja Monnery
- Sonja Volland
- Soo-Kyung Park
- Sophia Mazurek
- Sophie Arnold
- Sophie Birch
- Sophie Halpin
- Sophie Kennedy-Hay
- Sophie Limou
- Sophie Murdoch
- Sophie Packham
- Sophie Twiss
- Sophie Venturelli
- Sorrell Tilbey
- Souad Rahmouni
- Souad Rahmouni
- Soumendu Manna
- Soumitra Sengupta
- Soumya Raychaudhuri
- Spencer Knight
- Srikanth Chukkambotla
- Srikanth Chukkambotla
- Srinivas Jakkula
- Stacey Duffy
- Stavros Fotiadis
- Stavroula Kanoni
- Stefan Schreiber
- Stefania Mantovani
- Stefania Pintus
- Stefanie Heilmann-Heimbach
- Stefanie Herrmann
- Stefano Aliberti
- Stefano Baratti
- Stefano Busani
- Stefano Ceri
- Stefano Ceri Baillie
- Stefano Duga
- Stefano Duga
- Stefano Rusconi
- Stella Aslibekyan
- Stella Barnass
- Stella Metherell
- Stephan Ripke
- Stephanie Finn
- Stephanie Lee
- Stephanie Rees
- Stephanie Roberts
- Stephen Bonner
- Stephen Brett
- Stephen Cole
- Stephen Digby
- Stephen Duberly
- Stephen J. Wicks
- Stephen Kegg
- Stephen Preston
- Stephen R. Knight
- Stephen Riffle
- Stephen Winchester
- Steve Dodds
- Steve Hershman
- Steve Rose
- Steven Ascolillo
- Steven Henderson
- Steven Laird
- Steven Liggett
- Stuart C. Sealfon
- Stuart D’Sylva
- Stuart Hartshorn
- Stuart McKechnie
- Stuart Moss
- Stéphanie Bibert
- Stéphanie Gofflot
- Sue Mepham
- Sue Spencer
- Sugyeong Kim
- Suleman Mulla
- Sulggi Lee
- Sumit Kumar
- Sun Ha Jee
- Sundeep Kaul
- Sungmin Kym
- Sunmie Kim
- Susan Anderson
- Susan Butler
- Susan Chapman
- Susan Fowler
- Susan Hope
- Susan Jain
- Susan Larkin
- Susan O’Connell
- Susan Walker
- Susanna Croci
- Susanna Guerrini
- Susannah Glasgow
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- Susanne Cathcart
- Susanne Dudman
- Susie Ferguson
- Susie O’Sullivan
- Susumu Isogai
- Suzannah Lant
- Suzanne Allibone
- Suzanne Brooks
- Suzanne Clements
- Suzanne Geerlings
- Suzanne Naylor
- Suzanne Wood
- Suzie Marriott
- Sweyn Garrioch
- Syamlan Ali
- Sándor Szalma
- Séverine Camby
- Søren Brunak
- T. Brahier
- T. Egger
- T. Geary
- T. Rochat Negro
- Tabitha Newman
- Tabitha Rees
- Tadanaga Shimada
- Tadao Nagasaki
- Tadashi Manabe
- Tahera Patel
- Tahira Ishaq
- Taisuke Isono
- Taka-Aki Nakada
- Takahide Kikuchi
- Takahiro Fukui
- Takanori Asakura
- Takanori Hasegawa
- Takanori Kanai
- Takao Mochimaru
- Takashi Inoue
- Takashi Ishiguro
- Takashi Kagaya
- Takashi Ogura
- Takashi Yoshiyama
- Takatoshi Enomoto
- Takayuki Honda
- Takayuki Niitsu
- Takayuki Shibusawa
- Takayuki Shiroyama
- Takehiko Ohba
- Takehiro Izumo
- Takenori Okada
- Takeshi Takahashi
- Takuro Nii
- Takuya Hashino
- Tala Abdullah
- Tamas Leiner
- Tamas Szakmany
- Tamas Szakmany
- Tammy Gilchrist
- Tanja Wesse
- Tara McHugh
- Taranprit Saluja
- Tatiana Pogreban
- Tatsuhiko Anzai
- Taya Anderson
- Teishel Joefield
- Tenghao Zheng
- Teresa Behan
- Teresa Filshtein-Sonmez
- Teresa Scott
- Terry Foster
- Terry Martin
- Tess Levy
- Tessa Prince
- Tetsuo Shimizu
- Tetsuya Shiomi
- Tetsuya Ueda
- Thapas Nagarajan
- Theo Geijtenbeek
- Thogulava Kannan
- Thomas Bahmer
- Thomas Bemand
- Thomas Eggermann
- Thomas Illig
- Thomas Kong
- Thomas Lamb
- Thomas M. Drake
- Thorsten Brenner
- Thushan de Silva
- Tim Martindale
- Tim Owen Jones
- Tim Reynolds
- Tim Smith
- Tim Smith
- Timothy Felton
- Timothy S. Chang
- Timothy Walsh
- Tina Coventry
- Tinashe Samakomva
- Tiziana Bachetti
- Tobias L. Lenz
- Tobias Rankin
- Tohru Takata
- Tom Burden
- Tom Clark
- Tom Fletcher
- Tom Fowler
- Tom H. Karlsen
- Tom Lawton
- Tom Reijnders
- Tom Solomon
- Tom Stambach
- Tom van der Poll
- Tomas Pumarola
- Tomohiro Adachi
- Tomohisa Shoko
- Tomoko Nakanishi
- Tomonori Imamura
- Tomoo Ishii
- Tomouki Ogata
- Tomoya Baba
- Tomoya Tateishi
- Tomoya Tsuchida
- Tomoyuki Yoshihara
- Tonicha Nortcliffe
- Tony Wackett
- Tony Whitehouse
- Tooraj Mirshahi
- Toran Williams
- Torsten Feldt
- Toru Yoshida
- Toshio Odani
- Toshiro Sato
- Toshitaka Maeno
- Toshiyuki Hirano
- Toshiyuki Kita
- Tracey Cosier
- Tracey Hodgkiss
- Tracie Arden
- Tracy Baird
- Tracy Duncan
- Tracy Hazelton
- Tracy Lewis
- Tracy Marsden
- Tracy Wood
- Travis O’Brien
- Trevor Paterson
- Trevor R. Jones
- Triin Laisk
- Trine Folseraas
- Trinidad Gonzalez Cejudo
- Tristan Dyer
- Tsuyoshi Oguma
- Tullio Trotta
- Tõnu Esko
- Ulf Landmesser
- Ulrike Protzer
- Una Poultney
- Unnur Thorsteinsdottir
- Ute Hehr
- V. D’Acremont
- V. Erard
- V. Eric Kerchberger
- V. Suttels
- Val Irvine
- Valentina Anemoli
- Valentina Perticaroli
- Valeria Rimoldi
- Valerie Beech
- Valerie Joan Page
- Valery Ilinsky
- Valli Ratnam
- Valter Monzani
- Vanessa Harris
- Vanessa Linnett
- Vanessa Linnett
- Vanessa Sancho-Shimizu
- Varun Sarathy
- Vegard Skogen
- Verena Keitel
- Veronica Wagstaff
- Veronika Pristopan
- Veronique Vitart
- Verónica Terrón Arcos
- Vicente Friaza
- Vicky Martinson
- Vicky Thomas
- Vicky Thwaites
- Vicky Thwaites
- Victor Andrade
- Victor Moreno
- Victor Moreno
- Victoria Bastion
- Victoria Bridgett
- Victoria Clark
- Victoria E. Shaw
- Victoria Lake
- Victoria Maynard
- Victoria Parikh
- Victoria Parris
- Victoria Parris
- Victoria Shaw
- Victoria Slater
- Victoria Tuckey
- Victoria Turner
- Victoria Waugh
- Vid Prijatelj
- Vidya Kasipandian
- Vidya Kasipandian
- Vijay G. Sankaran
- Vikki Caruth
- Vikki Crickmore
- Vikram Anumakonda
- Vincent Mooser
- Vincenzo Forgetta
- Vincenzo Salpietro
- Vinodh Krishnamurthy
- Vishal Amin
- Vita Rovite
- Véronique Erard
- W. C. Albrich
- W. Joost Wiersinga
- Wadha Al-Muftah
- Wan Beom Park
- Wanying Zhu
- Waqas Khaliq
- Watkins Claire
- Wei Shen Lim
- Wei Zhou
- Wendy Chung
- Wendy Goddard
- Wendy Harrison
- Wendy McCormick
- Wendy S. Barclay
- Wenhan Lu
- Werner Albrich
- Wiesia Woodyatt
- Will Reynolds
- Willemke Stilma
- William A. Paxton
- William Greenhalf
- William Greenhalf
- William James Hurt
- Wilna Oosthuyzen
- Wim Timens
- Wolfgang Albrecht
- Wolfgang Peter
- Wolfgang Poller
- Woojin Seok
- Xavier Farre
- Xavier Farré
- Xavier Peyrassol
- Xia Shen
- Xiao Chang
- Xiaoli Yi
- Xiaomin Wang
- Xiaoqing Xue
- Ximo Dopazo
- Xinyi Qiu
- Xueqing Wang
- Y. Lannepoudenx
- Yan V. Sun
- Yang Wu
- Yascha Khodamoradi
- Yaser Al-Sarraj
- Yasmin Choudhury
- Yasmin DeAth
- Yasmin Hussain
- Yasmine Belhaj
- Yasuhiro Gon
- Yasuhiro Kimura
- Yasuhito Nannya
- Yasuko Fuchimoto
- Yasunari Kaneyama
- Yasunari Miyazaki
- Yasushi Nakano
- Yat S. So
- Yen-Chen Anne Feng
- Yeon-Sook Kim
- Yi Ding
- Yohan Bossé
- Yohei Funatsu
- Yohei Mikami
- Yoji Nagasaki
- Yoko Shibata
- Yolanda Baird
- Yong Huang
- Yoosoo Chang
- Yoshiaki Inoue
- Yoshifumi Kimizuka
- Yoshifumi Uwamino
- Yoshihiko Nakamura
- Yoshihiro Eriguchi
- Yoshihiro Hirai
- Yoshikazu Mutoh
- Yoshimi Noda
- Yoshinori Hasegawa
- Yoshinori Tanino
- Yoshinori Yasui
- Yoshitaka Oyamada
- Yoshito Takeda
- Yoshiyuki Sekikawa
- Yosuke Omae
- Yosuke Tanigawa
- Yosuke Tanigawa
- Yotaro Takaku
- Young Rock Jang
- Younghun Han
- Younhe Lee
- Youssef Bouysran
- Yu Kusaka
- Yu Min Kang
- Yuichi Adachi
- Yuichi Maeda
- Yuichiro Kitagawa
- Yuichiro Yamada
- Yuji Uchimura
- Yuk-Lam Ho
- Yuki Bradford
- Yuki Sato
- Yuki Togashi
- Yukiko Nakajima
- Yukinori Okada
- Yukinori Okada
- Yuko Kitagawa
- Yuko Komase
- Yusuf Cheema
- Yusuke Chihara
- Yusuke Suzuki
- Yuta Kono
- Yuval Itan
- Yuya Shirai
- Yves Beguin
- Yvette Thirlwall
- Yvonne Jackson
- Zacharia Hamidi
- Zahira Maqsood
- Zakaula Belagodu
- Zaman Afrasiabi
- Zehra Karadeniz
- Zena Bradshaw
- Zhijian Yang
- Ziortza Fernandez
- Zoe Alldis
- Zoe Coton
- Zoe Daly
- Zoe Garland
- Zoe Lamond
- Zoe Prime
- Zoe Scott
- Zohra Omar
- Zohreh Farzad
- Zoltan Takats
- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 08/07/2021
- Field of study
No full textAbstractThe genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-191,2, host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across 19 countries. We report 13 genome-wide significant loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of these loci correspond to previously documented associations to lung or autoimmune and inflammatory diseases3–7. They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated with COVID-19 was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks. This working model of international collaboration underscores what is possible for future genetic discoveries in emerging pandemics, or indeed for any complex human disease.</jats:p
