Regression games

The solution of a TU cooperative game can be a distribution of the value of the grand coalition, i.e. it can be a distribution of the payo (utility) all the players together achieve. In a regression model, the evaluation of the explanatory variables can be a distribution of the overall t, i.e. the t of the model every regressor variable is involved. Furthermore, we can take regression models as TU cooperative games where the explanatory (regressor) variables are the players. In this paper we introduce the class of regression games, characterize it and apply the Shapley value to evaluating the explanatory variables in regression models. In order to support our approach we consider Young (1985)'s axiomatization of the Shapley value, and conclude that the Shapley value is a reasonable tool to evaluate the explanatory variables of regression models

Feminist Perspectivism: A Revised Standpoint Theory

The heart of this thesis is an examination into the relevant differences between Nietzsche’s perspectivism and standpoint theory. Briefly, both standpoint theory and perspectivism have been subjected to various charges that dissolve into two major ones, which are worthy of additional scrutiny: the charges of essentialism and incoherence. My overall argument in thesis is that standpoint theory, in spite of recent feminist defense, is still susceptible to these charges, and this proves counterproductive to its aims of combatting marginalization. Moreover, I argue that Nietzsche’s perspectivism provides a corrective to the short comings of standpoint theory

Thermal adaptation and clinal mitochondrial DNA variation of European anchovy

Natural populations of widely distributed organisms often exhibit genetic clinal variation over their geographical ranges. The European anchovy, Engraulis encrasicolus, illustrates this by displaying a two-clade mitochondrial structure clinally arranged along the eastern Atlantic. One clade has low frequencies at higher latitudes, whereas the other has an anti-tropical distribution, with frequencies decreasing towards the tropics. The distribution pattern of these clades has been explained as a consequence of secondary contact after an ancient geographical isolation. However, it is not unlikely that selection acts on mitochondria whose genes are involved in relevant oxidative phosphorylation processes. In this study, we performed selection tests on a fragment of 1044 bp of the mitochondrial cytochrome b gene using 455 individuals from 18 locations. We also tested correlations of six environmental features: temperature, salinity, apparent oxygen utilization and nutrient concentrations of phosphate, nitrate and silicate, on a compilation of mitochondrial clade frequencies from 66 sampling sites comprising 2776 specimens from previously published studies. Positive selection in a single codon was detected predominantly (99%) in the anti-tropical clade and temperature was the most relevant environmental predictor, contributing with 59% of the variance in the geographical distribution of clade frequencies. These findings strongly suggest that temperature is shaping the contemporary distribution of mitochondrial DNA clade frequencies in the European anchovy.FCT [SFRH/BD/36600/2007, IF/00043/2012

The Completeness of Physiotherapy Patient Registers in Kigali, Rwanda

Background: The patient register is a specialized medical record that facilitates professional requirements, including continuity of service, quality of care, administrative data management including patient billing and resource allocation, medico-legal requirements, policy decisions, research and education. A Rehabilitation Desk was established in the Ministry of Health in Rwanda, but this position has remained vacant for a number of years. There is therefore no central aggregation of the scope or volume of work done by physiotherapists in Rwanda. Purpose: This paper describes the status of physiotherapy patient registers, which were used in a larger study that aimed to determine the character and nature of patients presenting for physiotherapy at hospitals that are routinely used for the clinical teaching of physiotherapy students. Methods: A retrospective review of all physiotherapy registers from five purposively selected hospitals in and around Kigali was employed. All register entries from the year 2009 were reviewed and transcribed using a pre-coded, researcher-designed and piloted checklist. Data were entered and analyzed using Microsoft Excel 2007. Descriptive statistics were used to characterize register data. Results: A total of 145128 patients were registered in the five hospitals during 2009, and of these 3476 were registered in the physiotherapy department. All hospitals used traditional paper-based registers. Missing entries were observed on 1902 (55%) entries, most often for the ‘residential address’ (17%) and ‘gender’ (14.2%) variables.Furthermore, there were peculiar challenges observed pertaining to register entries of the ‘patient diagnosis. Conclusion: The study found a high frequency of missing register entries. Our findings limit the usefulness of physiotherapy patient registers to fulfill the obligatory professional requirements and to inform planning for services

Determinants of Care Seeking for Persons with Low Back and Neck Pain Treated By Physicians, Chiropractors or Physical Therapists

Low back and neck pain are frequent reasons for adults to seek healthcare. Three types of practitioners are commonly used in the United States: physicians, chiropractors and physical therapists. In this study, Andersen\u27s Behavioral Model of Health Services Utilization is used to examine care seeking and provider selection. Estimates of back and neck pain prevalence in the United States are presented as well as care seeking rates and care consumption estimates for patients who used the three providers of interest. Multivariate regression analyses are presented that model the variables that most influence care seeking and provider selection.Cases with the conditions of low back pain and neck pain were drawn from the Medical Expenditure Panel Survey Panel 6 participants. Episodes of care and non-care were defined and the provider used during an episode was identified.Determinants of care seeking for low back pain included MSA status, insurance coverage, perceived health status, number of comorbidities and number of episodes. Determinants of care seeking for neck pain included insurance coverage and number of episodes. When condition was included in the analysis, it was a determinant of care seeking. All of these variables are enabling factors or need factors in Andersen\u27s model.In the analysis of provider selection for low back pain, variables that determined the provider from whom care was sought included patient age, gender, race, ethnicity, marital status, MSA status, insurance coverage, perceived health status, if the condition was disabling and number of episodes. In the analysis of provider selection for neck pain, variables that determined the provider from whom care was sought included patient ethnicity, marital status, and if the condition was disabling.Andersen\u27s Behavioral Model adequately predicts care seeking in LBP and NP with enabling and need factors playing a predominant role. In terms of equity of access this finding indicates a problem of access to care for persons who were uninsured. In the case of provider selection, all the constructs from the model were found to have a role in prediction indicating that access may be inequitable in the case of some providers

Trombone Shout: Instrumental Voices in the United House of Prayer for All People

This dissertation is an ethnography of an African American sacred music tradition – the trombone worship bands of the United House of Prayer for All People (UHOP) – that examines the ways in which musical aesthetics mediate racial and economic marginality and religious authority. Musical worship featuring these “shout bands,” involves UHOP members in an embodied performance of religious discourse, including actualizing the boundaries of sanctified interiority, confirming the charismatic authority of the organization’s sacralized leader, and constituting the independence and sovereignty of the UHOP Kingdom. The project is animated by a central question: given continuities in repertoire, performance practice, and theology between UHOP shout bands and other Black gospel practices, why is musical worship at the UHOP organized around the trombone rather than the human voice? The dissertation answers this question dialectically by showing how shout band music-making offers solutions to the ethical and theological issues members face, while UHOP theological discourse capitalizes on the sensory affordances of musical practice. The opening chapter introduces the role of the shout band in the context of UHOP worship services, framing musical practice as the enactment of sacred divisions of space and subjectivity. This chapter also depicts the feedback loop between worship practice and scriptural interpretation by introducing UHOP-specific idioms of Biblical literalism and re-enactment. Chapter two dilates on the connections between musical microsocialities and forms of authority through an analysis of the “figure of call-and-response” as a medium for the bishop’s charismatic authority. In the final chapter, I survey a variety of UHOP state-mimetic forms – that is, forms appropriated from the symbolic repertoire of the United States government – as points of entry into the ways that members actualize a shared notion of “freedom.

Identification of Pharmacological Modulators of HMGB1-Induced Inflammatory Response by Cell-Based Screening

High mobility group box 1 (HMGB1), a highly conserved, ubiquitous protein, is released into the circulation during sterile inflammation (e.g. arthritis, trauma) and circulatory shock. It participates in the pathogenesis of delayed inflammatory responses and organ dysfunction. While several molecules have been identified that modulate the release of HMGB1, less attention has been paid to identify pharmacological inhibitors of the downstream inflammatory processes elicited by HMGB1 (C23-C45 disulfide C106 thiol form). In the current study, a cell-based medium-throughput screening of a 5000+ compound focused library of clinical drugs and drug-like compounds was performed in murine RAW264.7 macrophages, in order to identify modulators of HMGB1-induced tumor-necrosis factor alpha (TNFα) production. Clinically used drugs that suppressed HMGB1-induced TNFα production included glucocorticoids, beta agonists, and the anti-HIV compound indinavir. A re-screen of the NIH clinical compound library identified beta-agonists and various intracellular cAMP enhancers as compounds that potentiate the inhibitory effect of glucocorticoids on HMGB1-induced TNFα production. The molecular pathways involved in this synergistic anti-inflammatory effect are related, at least in part, to inhibition of TNFα mRNA synthesis via a synergistic suppression of ERK/IκB activation. Inhibition of TNFα production by prednisolone+salbutamol pretreatment was also confirmed in vivo in mice subjected to HMGB1 injection; this effect was more pronounced than the effect of either of the agents administered separately. The current study unveils several drug-like modulators of HMGB1-mediated inflammatory responses and offers pharmacological directions for the therapeutic suppression of inflammatory responses in HMGB1-dependent diseases. © 2013 Gerö et al

Scale dependency in the hydromorphological control of a stream ecosystem functioning

Physical habitat degradation is prevalent in river ecosystems. Although still little is known about the ecological consequences of altered hydromorphology, understanding the factors at play can contribute to sustainable environmental management. In this study we aimed to identify the hydromorphological features controlling a key ecosystem function and the spatial scales where such linkages operate. As hydromorphological and chemical pressures often occur in parallel, we examined the relative importance of hydromorphological and chemical factors as determinants of leaf breakdown. Leaf breakdown assays were investigated at 82 sites of rivers throughout the French territory. Leaf breakdown data were then crossed with data on water quality and with a multi-scale hydro- morphological assessment (i.e. upstream catchment, river segment, reach and habitat) when quantitative data were available. Microbial and total leaf breakdown rates exhibited differential responses to both hydromorphological and chemical alterations. Relationships between the chemical quality of the water and leaf breakdown were weak, while hydromorphological integrity explained independently up to 84.2% of leaf breakdown. Hydrological and morphological parameters were the main predictors of microbial leaf breakdown, whereas hydrological parameters had a major effect on total leaf breakdown, particularly at large scales, while morphological parameters were important at smaller scales. Microbial leaf breakdown were best predicted by hydromorphological features defined at the upstream catchment level whereas total leaf breakdown were best predicted by reach and habitat level geomorphic variables. This study demonstrates the use of leaf breakdown in a biomonitoring context and the importance of hydromorphological integrity for the functioning of running water. It provides new insights for envi- ronmental decision-makers to identify the management and restoration actions that have to be un- dertaken including the hydromorphogical features that should be kept in minimal maintenance to support leaf breakdown