The efficacy of stereotactic body radiation therapy on huge hepatocellular carcinoma unsuitable for other local modalities

BACKGROUND AND AIM: To evaluate the safety and efficacy of Cyberknife stereotactic body radiation therapy (SBRT) and its effect on survival in patients with unresectable huge hepatocellular carcinoma (HCC) unsuitable of other standard treatment option. METHODS: Between 2009 and 2011, 22 patients with unresectable huge HCC (≧10 cm) were treated with SBRT. dose ranged from 26 Gy to 40 Gy in five fractions. Overall survival (OS) and disease-progression free survival (DPFS) were determined by Kaplan-Meier analysis. Tumor response and toxicities were also assessed. RESULTS: After a median follow-up of 11.5 month (range 2–46 months). The objective response rate was achieved in 86.3% (complete response (CR): 22.7% and partial response (PR): 63.6%). The 1-yr. local control rate was 55.56%. The 1-year OS was 50% and median survival was 11 months (range 2–46 months). In univariate analysis, Child-Pugh stage (p = 0.0056) and SBRT dose (p = 0.0017) were significant factors for survival. However, in multivariate analysis, SBRT dose (p = 0.0072) was the most significant factor, while Child-Pugh stage of borderline significance. (p = 0.0514). Acute toxicities were mild and well tolerated. CONCLUSION: This study showed that SBRT can be delivered safely to huge HCC and achieved a substantial tumor regression and survival. The results suggest this technique should be considered a salvage treatment. However, local and regional recurrence remain the major cause of failure. Further studies of combination of SBRT and other treatment modalities may be reasonable

A Simple Model for Cavity Enhanced Slow Lights in Vertical Cavity Surface Emission Lasers

We develop a simple model for the slow lights in Vertical Cavity Surface Emission Lasers (VCSELs), with the combination of cavity and population pulsation effects. The dependences of probe signal power, injection bias current and wavelength detuning for the group delays are demonstrated numerically and experimentally. Up to 65 ps group delays and up to 10 GHz modulation frequency can be achieved in the room temperature at the wavelength of 1.3 $\mu$m. The most significant feature of our VCSEL device is that the length of active region is only several $\mu$m long. Based on the experimental parameters of quantum dot VCSEL structures, we show that the resonance effect of laser cavity plays a significant role to enhance the group delays

Potassium {4-[(3S,6S,9S)-3,6-dibenzyl-9-isopropyl-4,7,10-trioxo-11–oxa-2,5,8-triazadodecyl]phenyl}trifluoroborate

[[abstract]]The reported compound 4 was synthesized and fully characterized by 1H NMR, 13C NMR, 11B NMR, 19F NMR, and high resolution mass spectrometry.[[booktype]]電子版[[countrycodes]]CH

Application of the SUSTAIN Model to a Watershed-Scale Case for Water Quality Management

[[abstract]]Low impact development (LID) is a relatively new concept in land use management that aims to maintain hydrological conditions at a predevelopment level without deteriorating water quality during land development. The United States Environmental Protection Agency (USEPA) developed the System for Urban Stormwater Treatment and Analysis Integration model (SUSTAIN) to evaluate the performance of LID practices at different spatial scales; however, the application of this model has been limited relative to LID modeling. In this study, the SUSTAIN model was applied to a Taiwanese watershed. Model calibration and verification were performed, and different types of LID facilities were evaluated. The model simulation process and the verified model parameters could be used in other cases. Four LID scenarios combining bioretention ponds, grass swales, and pervious pavements were designed based on the land characteristics. For the SUSTAIN model simulation, the results showed that pollution reduction was mainly due to water quantity reduction, infiltration was the dominant mechanism and plant interception had a minor effect on the treatment. The simulation results were used to rank the primary areas for nonpoint source pollution and identify effective LID practices. In addition to the case study, a sensitivity analysis of the model parameters was performed, showing that the soil infiltration rate was the most sensitive parameter affecting the LID performance. The objectives of the study are to confirm the applicability of the SUSTAIN model and to assess the effectiveness of LID practices in the studied watershed.[[notice]]補正完畢[[incitationindex]]SCI[[booktype]]電子