Trustee: A Trust Management System for Fog-enabled Cyber Physical Systems

In this paper, we propose a lightweight trust management system (TMS) for fog-enabled cyber physical systems (Fog-CPS). Trust computation is based on multi-factor and multi-dimensional parameters, and formulated as a statistical regression problem which is solved by employing random forest regression model. Additionally, as the Fog-CPS systems could be deployed in open and unprotected environments, the CPS devices and fog nodes are vulnerable to numerous attacks namely, collusion, self-promotion, badmouthing, ballot-stuffing, and opportunistic service. The compromised entities can impact the accuracy of trust computation model by increasing/decreasing the trust of other nodes. These challenges are addressed by designing a generic trust credibility model which can countermeasures the compromise of both CPS devices and fog nodes. The credibility of each newly computed trust value is evaluated and subsequently adjusted by correlating it with a standard deviation threshold. The standard deviation is quantified by computing the trust in two configurations of hostile environments and subsequently comparing it with the trust value in a legitimate/normal environment. Our results demonstrate that credibility model successfully countermeasures the malicious behaviour of all Fog-CPS entities i.e. CPS devices and fog nodes. The multi-factor trust assessment and credibility evaluation enable accurate and precise trust computation and guarantee a dependable Fog-CPS system

The Inheritance of Yield and Yield Components of Five Wheat Hybrid Populations Under Drought Conditions

The magnitude of genetic inheritance and expected genetic advance are important for the prediction of response to selection in diverse environments and provide the basis for planning and evaluating breeding programs. This work investigated the inheritance of traits related to drought in wheat under natural drought conditions. Cross combinations were made to produce F1 and F2 hybrid populations, which were evaluated in a randomized completed block design with three replications at University of Agriculture, Faisalabad, Pakistan. Six wheat varieties/lines and six derived F2 hybrids were studied to ascertain heritability and genetic advance for plant height, days taken to maturity, number of tillers per plant, spike length, number of grains per spike, 1000-grain weight, and grain yield per plant. Data were collected and subjected to statistical genetic analyses. Heritability estimates and expected genetic advance for plant height, days taken to maturity, number of tillers per plant, 1000-grain weight and grain yield per plant were high for the entire cross combinations while the estimates for spike length and number of grains per spike were relatively low. Our results suggest that improvement for these characters should be faster because of higher heritabilities and greater phenotypic variation. Prospects of genetic improvement for all the characters studied are evident. The most promising cross combinations were WL60 × LU26S and WL61 × LU26S. These traits, therefore, deserve better attention in future breeding programs for evolving better wheat for stress environments

Investigation of single beam near-infrared free space optical communication under different weather anomalies

The Free space optics (FSO) is a wireless optical communication system that connects directly to the atmosphere, where the connection is established between transmitter and receiver within in the line of sight. The FSO poses a high-speed broadband, which is the last mile wireless optical communication, deployed relatively fast. However, there are some weather factors may affect the performance of FSO transmission. In this paper, we analyzed the performance of Non-Return to Zero (NRZ) modulation schemes, which is used in FSO communication under extreme weather conditions over a range of 2Km. The performance has been analyzed under 980nm wavelength, Bit Error Rate (BER), and Q-factor using Opt system. The largest attenuation measured is 340dB/Km, correlate to the visibility of 50m. In addition the visibility exceeding about 50m, The Kruse formula provides a good measurement of optical attenuation over long distances under the clear weather and haze conditions respectively

Clinical expression of plakophilin-2 mutations in familial arrhythmogenic right ventricular cardiomyopathy

Background - Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited cardiac disorder characterized by loss of cardiomyocytes and their replacement by adipose and fibrous tissue. It is considered a disease of cell adhesion because mutations in desmosomal genes, desmoplakin and plakoglobin, have been implicated in the pathogenesis of ARVC. In a recent report, mutations in plakophilin-2, a gene highly expressed in cardiac desmosomes, have been shown to cause ARVC.Methods and Results - We investigated 100 white patients with ARVC for mutations in plakophilin-2. Nine different mutations were identified by direct sequencing in 11 cases. Five of these mutations are novel (A733fsX740, L586fsX658, V570fsX576, R413X, and P533fsX561) and predicted to cause a premature truncation of the plakophilin-2 protein. Family studies showed incomplete disease expression in mutation carriers and identified a number of individuals who would be misdiagnosed with the existing International Task Force and modified diagnostic criteria for ARVC.Conclusions - In this study, we provide new evidence that mutations in the desmosomal plakophilin-2 gene can cause ARVC. A systematic clinical evaluation of mutation carriers within families demonstrated variable phenotypic expression, even among individuals with the same mutation, and highlighted the need for a more accurate set of diagnostic criteria for ARVC

Effect of protonation state and N-acetylation of chitosan on its interaction with xanthan gum: a molecular dynamics simulation study

Hydrophilic matrices composed of chitosan (CS) and xanthan gum (XG) complexes are of pharmaceutical interest in relation to drug delivery due to their ability to control the release of active ingredients. Molecular dynamics simulations (MDs) have been performed in order to obtain information pertaining to the effect of the state of protonation and degree of N-acetylation (DA) on the molecular conformation of chitosan and its ability to interact with xanthan gum in aqueous solutions. The conformational flexibility of CS was found to be highly dependent on its state of protonation. Upon complexation with XG, a substantial restriction in free rotation around the glycosidic bond was noticed in protonated CS dimers regardless of their DA, whereas deprotonated molecules preserved their free mobility. Calculated values for the free energy of binding between CS and XG revealed the dominant contribution of electrostatic forces on the formation of complexes and that the most stable complexes were formed when CS was at least half-protonated and the DA was ≤50%. The results obtained provide an insight into the main factors governing the interaction between CS and XG, such that they can be manipulated accordingly to produce complexes with the desired controlled-release effect

Dealing with missing standard deviation and mean values in meta-analysis of continuous outcomes: a systematic review

Background: Rigorous, informative meta-analyses rely on availability of appropriate summary statistics or individual participant data. For continuous outcomes, especially those with naturally skewed distributions, summary information on the mean or variability often goes unreported. While full reporting of original trial data is the ideal, we sought to identify methods for handling unreported mean or variability summary statistics in meta-analysis. Methods: We undertook two systematic literature reviews to identify methodological approaches used to deal with missing mean or variability summary statistics. Five electronic databases were searched, in addition to the Cochrane Colloquium abstract books and the Cochrane Statistics Methods Group mailing list archive. We also conducted cited reference searching and emailed topic experts to identify recent methodological developments. Details recorded included the description of the method, the information required to implement the method, any underlying assumptions and whether the method could be readily applied in standard statistical software. We provided a summary description of the methods identified, illustrating selected methods in example meta-analysis scenarios. Results: For missing standard deviations (SDs), following screening of 503 articles, fifteen methods were identified in addition to those reported in a previous review. These included Bayesian hierarchical modelling at the meta-analysis level; summary statistic level imputation based on observed SD values from other trials in the meta-analysis; a practical approximation based on the range; and algebraic estimation of the SD based on other summary statistics. Following screening of 1124 articles for methods estimating the mean, one approximate Bayesian computation approach and three papers based on alternative summary statistics were identified. Illustrative meta-analyses showed that when replacing a missing SD the approximation using the range minimised loss of precision and generally performed better than omitting trials. When estimating missing means, a formula using the median, lower quartile and upper quartile performed best in preserving the precision of the meta-analysis findings, although in some scenarios, omitting trials gave superior results. Conclusions: Methods based on summary statistics (minimum, maximum, lower quartile, upper quartile, median) reported in the literature facilitate more comprehensive inclusion of randomised controlled trials with missing mean or variability summary statistics within meta-analyses

Changing women's roles, changing environmental knowledges: evidence from Upper Egypt

The aim of this paper is to investigate the ways in which changing gender roles in a Bedouin community in Upper Egypt, brought about by settlement over the last 20 years on the shores of Lake Nasser, have impacted on the accumulation and development of indigenous environmental knowledges by Bedouin women. The research was carried out among four groups of Ababda Bedouin in the Eastern Desert of Egypt and involved in-depth monthly conversations carried out over a period of 12 months. The main conclusions of the study are that the women of the study area have had to develop new knowledges which, in some cases, are now different from those held by men because of the different economic circumstances in which many find themselves; that these knowledges are fluid, dynamic and ever-changing with their own internal dynamism; and that socially constructed notions of gender are vital in the development process, notions that are sensitive to both men's and women's interests and their interrelationships

Heat Shock Factor 1 is a Substrate for p38 Mitogen-Activated Protein Kinases

Heat shock factor 1 (HSF1) monitors the structural integrity of the proteome. Phosphorylation at S326 is a hallmark for HSF1 activation, but the identity of the kinase(s) phosphorylating this site has remained elusive. We show here that the dietary agent phenethyl isothiocyanate (PEITC) inhibits heat shock protein 90 (Hsp90), the main negative regulator of HSF1; activates p38 mitogen-activated protein kinase (MAPK); and increases S326 phosphorylation, trimerization, and nuclear translocation of HSF1, and the transcription of a luciferase reporter, as well as the endogenous prototypic HSF1 target Hsp70. In vitro, all members of the p38 MAPK family rapidly and stoichiometrically catalyze the S326 phosphorylation. The use of stable knockdown cell lines and inhibitors indicated that among the p38 MAPKs, p38γ is the principal isoform responsible for the phosphorylation of HSF1 at S326 in cells. A protease-mass spectrometry approach confirmed S326 phosphorylation and unexpectedly revealed that p38 MAPK also catalyzes the phosphorylation of HSF1 at S303/307, previously known repressive posttranslational modifications. Thus, we have identified p38 MAPKs as highly efficient catalysts for the phosphorylation of HSF1. Furthermore, our findings suggest that the magnitude and persistence of activation of p38 MAPK are important determinants of the extent and duration of the heat shock response