Cancer therapy, gonadal function, and fertility preservation: systematic review and meta-analysis

Our analysis is the first attempt at a systematic review of all currently published articles on fertility and fertility cryopreservation in cancer patients. Despite the limitations of existing data, and the pressing need for more comprehensive analysis of fertility in the context of cancer, the literature very clearly shows the impact of some cancers and treatments on fertility

Numerically Enhanced Thermal Inspection of Shuttle Solid Rocket Motor Inhibitor/Liner/Fuel Bondline

The Solid Rocket Motors (SRM’s) for the Space Shuttle are fabricated by laying up and molding materials, such as insulation, which are joined using adhesives, the adhesives being set along with the materials in a final curing process for an entire motor segment at a time. The resulting structure (Fig. 1) has two important properties from the point of view of inspection: integrity of the adhesive joints (bondlines) is of great importance, and the structure cannot be disassembled for inspection prior to use. Of particular interest are disbonds producing small voids (delaminations) at the bondlines. Specific delaminations can be located in service hardware only by using NDE methods. This paper reports on the application of thermal methods for performing such inspections

Understanding and (dis)trusting food assurance schemes::Consumer confidence and the ‘knowledge fix’

This paper uses evidence from focus groups with consumers in England to consider how consumers understand and evaluate a range of proxies or intermediary organisations that offer assurance about food and consumer products, particularly voluntary certification schemes. This addresses the current concern in developed economies about providing information in order to reconnect consumers with food producers and to support moves towards more local, fairly traded and sustainable production. However, we show that such a ‘knowledge fix’ approach of providing information may not reconnect consumers so easily. Participants found it particularly difficult to work out what certification involved and what kinds of organisations were providing assurance. They built vernacular typologies and comparative judgements that did not necessarily identify or prioritise ‘independent’ third-party certification as the gold standard, not least because of the practical difficulties of monitoring complex supply chains, and expressed confusion and scepticism about how well food assurance schemes could work in practice. Our results therefore problematise the knowledge fix urged in the literature and emphasise instead the need to better understand how consumers make sense of assurance information in different contexts

Cancer Therapy, Gonadal Function, and Fertility Preservation: Narrative Review.

PurposeFertility preservation was designed to help young patients overcome complications of cancer treatments, but its effectiveness is unknown. We sought to investigate how often patients with cancer are offered fertility preservation and if patients offered fertility preservation are more likely to have offspring.MethodsWe searched Embase (through 2022) and PubMed (through 2022). Our broad computerized search strategy was built upon using the keywords "chemotherapy," "radiation," and "fertility." The search took place on December 1, 2022. We included randomized and observational studies and excluded reviews and case reports/series.ResultsEighty-five articles that answered at least one of the research questions were included. Studies assessing fertoprotective therapies often rely on surrogate markers for fertility. Multiple factors affect these markers of fertility. The median premature ovarian failure rate among the intervention group was 18% (IQR, 12%-20%), and among the control group, it was 25% (IQR, 19%-33%). Five of 11 studies reported a significant benefit from fertoprotective therapy. Pregnancies occurred in a median of 21% (IQR, 6%-52%) of patients in the intervention group and 11% (IQR, 7-44) of patients in the control group, with three of seven studies reporting a higher percentage of pregnancies among the intervention group.ConclusionWe reviewed the literature on several questions surrounding fertility preservation and found that there is limited and low-quality research on these therapies in cancer. Hence, there is a strong need for studies, especially randomized studies, that follow patients with cancer who undergo fertility preservation and assess outcomes in which patients are most interested

Decadal hindcasts initialized using observed surface wind stress: Evaluation and prediction out to 2024

We use surface air temperature to evaluate the decadal forecast skill of the fully coupled Max Planck Institut Earth System Model (MPI-ESM) initialized using only surface wind stress applied to the ocean component of the model (Modini: Model initialization by partially coupled spin-up). Our analysis shows that the greenhouse gas forcing alone results in a significant forecast skill on the 2–5 and 6–9 year range even for uninitialized hindcasts. For the first forecast year, the forecast skill of Modini is generally comparable with previous initialization procedures applied to MPI-ESM. But only Modini is able to generate a significant skill (correlation) in the tropical Pacific for a 2–5 year (and to a lesser extent for a 6–9 year) hindcast. Modini is also better able to capture the observed hiatus in global warming in hindcast mode than the other methods. Finally, we present forecasts for 2015 and the average of years 2016–2019 and 2020–2024, predicting an end to the hiatus

Impact of brain tissue filtering on neurostimulation fields: A modeling study

Electrical neurostimulation techniques, such as deep brain stimulation (DBS) and transcranial magnetic stimulation (TMS), are increasingly used in the neurosciences, e.g., for studying brain function, and for neurotherapeutics, e.g., for treating depression, epilepsy, and Parkinson's disease. The characterization of electrical properties of brain tissue has guided our fundamental understanding and application of these methods, from electrophysiologic theory to clinical dosing-metrics. Nonetheless, prior computational models have primarily relied on ex-vivo impedance measurements. We recorded the in-vivo impedances of brain tissues during neurosurgical procedures and used these results to construct MRI guided computational models of TMS and DBS neurostimulatory fields and conductance-based models of neurons exposed to stimulation. We demonstrated that tissues carry neurostimulation currents through frequency dependent resistive and capacitive properties not typically accounted for by past neurostimulation modeling work. We show that these fundamental brain tissue properties can have significant effects on the neurostimulatory-fields (capacitive and resistive current composition and spatial/temporal dynamics) and neural responses (stimulation threshold, ionic currents, and membrane dynamics). These findings highlight the importance of tissue impedance properties on neurostimulation and impact our understanding of the biological mechanisms and technological potential of neurostimulatory methods.United States. Defense Advanced Research Projects Agency (Contract W31P4Q-09-C-0117)National Institute of Neurological Disorders and Stroke (U.S.) (Award R43NS062530)National Institute of Neurological Disorders and Stroke (U.S.) (Award 1R44NS080632

Traces of past activity in the Galactic Centre

The Milky Way centre hosts a supermassive Black Hole (BH) with a mass of ~4*10^6 M_Sun. Sgr A*, its electromagnetic counterpart, currently appears as an extremely weak source with a luminosity L~10^-9 L_Edd. The lowest known Eddington ratio BH. However, it was not always so; traces of "glorious" active periods can be found in the surrounding medium. We review here our current view of the X-ray emission from the Galactic Center (GC) and its environment, and the expected signatures (e.g. X-ray reflection) of a past flare. We discuss the history of Sgr A*'s past activity and its impact on the surrounding medium. The structure of the Central Molecular Zone (CMZ) has not changed significantly since the last active phase of Sgr A*. This relic torus provides us with the opportunity to image the structure of an AGN torus in exquisite detail.Comment: Invited refereed review. Chapter of the book: "Cosmic ray induced phenomenology in star forming environments" (eds. Olaf Reimer and Diego F. Torres